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C6orf25 is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. Zusätzlich bieten wir Ihnen C6orf25 Antikörper (30) und viele weitere Produktgruppen zu diesem Protein an.
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G6B seems to act through an autosomal recessive mode of disease transmission in this family and regarded as the gene responsible for the observed hematological disorder.
Heparin might modulate the interaction of G6b with its as yet unidentified protein ligand
G6B represents a novel inhibitory receptor found on the surface of platelets
G6b-B expression is highly restricted to peripheral CD4 (zeige CD4 Proteine)+ T cells and up-regulated by the IL-4 (zeige IL4 Proteine)-induced STAT6 (zeige STAT6 Proteine) pathway, suggesting that G6b-B is involved in regulation of the immune response by CD4 (zeige CD4 Proteine)+ T cell-mediated and IL-4 (zeige IL4 Proteine) induced regulatory mechanisms.
G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2 (zeige CLEC1B Proteine).
these findings establish G6b-B as a major inhibitory receptor regulating megakaryocyte activation, function, and platelet production.
This gene is a member of the immunoglobulin (Ig) superfamily and is located in the major histocompatibility complex (MHC) class III region. The protein encoded by this gene is a glycosylated, plasma membrane-bound cell surface receptor, but soluble isoforms encoded by some transcript variants have been found in the endoplasmic reticulum and Golgi before being secreted. Multiple transcript variants encoding different isoforms have been found for this gene.
, immunoglobulin receptor
, G6B protein
, G6b protein
, ITIM-receptor G6b-B