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The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. Zusätzlich bieten wir Ihnen Cholinergic Receptor, Nicotinic, delta (Muscle) Kits (12) und Cholinergic Receptor, Nicotinic, delta (Muscle) Proteine (7) und viele weitere Produktgruppen zu diesem Protein an.
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Amphibian Monoclonal CHRND Primary Antibody für ICC, IHC (fro) - ABIN266941
Froehner, Douville, Klink, Culp: Monoclonal antibodies to cytoplasmic domains of the acetylcholine receptor. in The Journal of biological chemistry 1983
Show all 3 Pubmed References
Data suggest mutation in invariant Cys-loop of CHRND (D140N) observed in muscle of one patient (11 y/o girl) with congenital myasthenia (w/ severe muscle weakness) alters conformation of ligand/acetylcholine binding site and receptor functionality.
This study showed that a single mutation of the delta subunit, L332P, allows the synapse in slow muscles to function but renders those in fast muscles almost nonfunctional.
These findings identify novel Golgi retention signals in the beta and delta subunit loops that regulate surface trafficking of assembled AChR and may help prevent surface expression of unassembled subunits.
No mutations were found in CHRNG, CHRND and CHRNA1 genes of Indian families with Escobar syndrome.
No CHRNA1, CHRNB1, or CHRND mutations were detected, but a homozygous RAPSN frameshift mutation, c.1177-1178delAA, was identified in a family with three children affected with lethal fetal akinesia sequence.
study reports homozygous nonsense mutations in CHRNA1 and CHRND and shows that they were lethal
Results describe the effects of a point mutation in the AChR delta subunit from a congenital myasthenia patient.
Mutation in the delta-subunit of nAChR suppresses the muscle defects caused by lack of dystrophin.
direct involvement of the AChR molecule in restricting receptor-rapsyn clusters to the synapse
sop(-/-) mutants are able to support normal potassium current development during early stages of development but at day 6 the potassium current density is significantly smaller than that in wild-type siblings. sodium current density is unaffected
Bone marrow-derived mesenchymal stem cells up-regulate skeletal muscle acetylcholine receptor delta subunit through NRG/ErbB3-mediated mitogen-activated protein kinase pathway.
Delay in maturation of the nAChR clusters during the early postnatal synapse elimination period in protein kinase C (PKCtheta; deficient mice coincides with a reduction in PKCtheta;-mediated phosphorylation of the nAChR delta subunit.
The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanisms.
The acetylcholine receptor of muscle has 5 subunits of 4 different types: 2 alpha and 1 each of beta, gamma and delta subunits. After acetylcholine binding, the receptor undergoes an extensive conformation change that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. Defects in this gene are a cause of multiple pterygium syndrome lethal type (MUPSL), congenital myasthenic syndrome slow-channel type (SCCMS), and congenital myasthenic syndrome fast-channel type (FCCMS). Several transcript variants, some protein-coding and some not, have been found for this gene.
acetylcholine receptor subunit delta
, acetylcholine receptor, nicotinic, delta (muscle)
, cholinergic receptor, nicotinic, delta polypeptide
, acetylcholine receptor delta subunit
, sofa potato
, cholinergic receptor, nicotinic, delta
, acetylcholine receptor subunit delta-like
, nicotinic acetylcholine receptor delta polypeptide
, AChR delta subunit
, acetylcholine receptor delta subunit precursor (AA -21 to 500)