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May be involved in mediating calcium-activated chloride conductance.
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Clca1 (zeige CLCA1 Antikörper) is not required for mucus synthesis, structure and barrier function in the murine colon.
mCLCA3 appears to modulate leukocyte response via IL-17 (zeige IL17A Antikörper) and murine CXCL-8 (zeige IL8 Antikörper) homologs in acute Staphylococcus aureus pneumonia which is well in line with the proposed function of hCLCA1 (zeige CLCA1 Antikörper) as a signaling molecule acting on alveolar macrophages.
Findings suggest that increased expression of a single-gene, mCLCA3, could simulate an asthma attack, and its mechanism may involve mCLCA3 overexpression up-regulating IL-13 (zeige IL13 Antikörper) expression.
PA-LPS (zeige TLR4 Antikörper)-induced MUC5AC and Clca3 expression is partly through Duox1 (zeige DUOX1 Antikörper)
these findings argue against a role of mCLCA3 in Ca(2 (zeige CA2 Antikörper) )-activated Cl(-) channel-mediated Cl(-) secretion in murine respiratory epithelia
a functional link between two distinct anion currents, ClC-3 (zeige CLCN3 Antikörper) and swelling-activated chloride current
conclude that hCLCA1 (zeige CLCA1 Antikörper) and mCLCA3 are non-integral membrane proteins and therefore cannot be chloride channels in their own right
Gob-5 (zeige CLCA1 Antikörper) expression is not essential for mucin (zeige SLC13A2 Antikörper) overproduction in vitro or in murine models of allergic asthma
We found that mClCA3 expression was significantly decreased in the colon and lung of the cftr (zeige CFTR Antikörper)-/- mice.
These observations reinforce findings that associate Gob-5 (zeige CLCA1 Antikörper) with goblet cell hyperplasia and mucus production in the allergic immune response, but also implicate Gob-5 (zeige CLCA1 Antikörper) in the regulation of tissue inflammation in the innate immune response.
May be involved in mediating calcium-activated chloride conductance. May play critical roles in goblet cell metaplasia, mucus hypersecretion, cystic fibrosis and AHR. May be involved in the regulation of mucus production and/or secretion by goblet cells. Involved in the regulation of tissue inflammation in the innate immune response. May play a role as a tumor suppressor. Induces MUC5AC.
calcium-activated chloride channel regulator 1
, chloride channel calcium activated 3
, calcium-activated chloride channel family member 3
, chloride channel calcium activated 2
, protein gob-5