ChaC, Cation Transport Regulator Homolog 1 (E. Coli) Proteine (CHAC1)

Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. Zusätzlich bieten wir Ihnen CHAC1 Antikörper (55) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CHAC1 69065 Q8R3J5
CHAC1 79094 Q9BUX1
Ratte CHAC1 CHAC1 362196 B3STU3
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Showing 4 out of 5 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$328.90
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CHAC1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,

Weitere Proteine zu ChaC, Cation Transport Regulator Homolog 1 (E. Coli) (CHAC1) Interaktionspartnern

Mouse (Murine) ChaC, Cation Transport Regulator Homolog 1 (E. Coli) (CHAC1) Interaktionspartner

  1. Study have shown that the 5' UTR of Chac1 plays an important role in expressing the full-length and short form of Chac1, and the expression level of Chac1 protein is predominantly regulated by its ubiquitination.

  2. Chac1 expression is detrimental to arsenite-treated cell survival and TRIB3 (zeige TRIB3 Proteine) is critical for restraining the pro-death potential of Chac1 during arsenite stress.

  3. Data indicate that Chac1 protein expression was only detected in the presence of MG132, a proteasome inhibitor.

  4. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.

Human ChaC, Cation Transport Regulator Homolog 1 (E. Coli) (CHAC1) Interaktionspartner

  1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis.

  2. Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 (zeige NOTCH3 Proteine) levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 (zeige NOTCH3 Proteine) activation, resulting in attenuation of Notch3 (zeige NOTCH3 Proteine)-mediated signaling pathways.

  3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 (zeige ATF4 Proteine) and ATF3 (zeige ATF3 Proteine) and a Bipartite ATF/CRE Regulatory Element.

  4. Botch regulates Notch (zeige NOTCH1 Proteine) signaling through deglycination and identify a posttranslational modification of Notch (zeige NOTCH1 Proteine) that plays an important role in neurogenesis.

  5. nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium

  6. High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer

CHAC1 Protein Überblick

Protein Überblick

Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity).

Genbezeichner und Symbole assoziert mit CHAC1

  • ChaC glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1)
  • ChaC, cation transport regulator 1 (Chac1)
  • ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (Chac1)
  • 1810008K03Rik Protein
  • RGD1307153 Protein

Bezeichner auf Proteinebene für CHAC1

cation transport regulator-like protein 1 , ChaC, cation transport regulator-like 1 , ChaC, cation transport regulator homolog 1 (E. coli) , blocks Notch protein , botch , cation transport regulator homolog 1 , neuroprotective protein 7

GENE ID SPEZIES
423209 Gallus gallus
467659 Pan troglodytes
705007 Macaca mulatta
100219118 Taeniopygia guttata
69065 Mus musculus
79094 Homo sapiens
487504 Canis lupus familiaris
505991 Bos taurus
362196 Rattus norvegicus
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