Ceramide Synthase 3 Proteine (CERS3)

Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis.

alle Proteine anzeigen Gen GeneID UniProt
Human CERS3 CERS3 204219 Q8IU89
Maus CERS3 CERS3 545975  
Ratte CERS3 CERS3 499174  
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Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,649.05
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,616.87
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
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Weitere Proteine zu Ceramide Synthase 3 (CERS3) Interaktionspartnern

Human Ceramide Synthase 3 (CERS3) Interaktionspartner

  1. Novel mutations in CERS3 co-segregated with the ichthyosis (zeige LBR Proteine) phenotype in six Iranian families.

  2. testis-specific (zeige THEG Proteine) SLs (zeige ALDH3A2 Proteine), which we also link to CerS3 in human testis, are quintessential for male fertility.

  3. Our findings demonstrate that synthesis of very long chain ceramides by CerS3 is a crucial early step for the skin barrier formation and link disorders presenting with congenital ichthyosis (zeige LBR Proteine) to defects in sphingolipid metabolism and lipid architecture.

  4. these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis.

Mouse (Murine) Ceramide Synthase 3 (CERS3) Interaktionspartner

  1. testis-specific (zeige AIF1 Proteine) SLs (zeige ALDH3A2 Proteine), which we also link to CerS3 in human testis, are quintessential for male fertility.

  2. Data indicate that oxidized phospholipids (OxPLs)-induced ceramide synthases (CerS1 (zeige CERS1 Proteine)-Cers6 (zeige CERS6 Proteine)) activity in macrophages is responsible for the accumulation of ceramide.

  3. Deficiency of CerS3 in mice results in complete loss of ceramides with ultra-long-chain acyl moities (>/=C26), lack of continuous extracellular lipid lamellae and a non-functional cornified lipid envelope.

  4. The isolation and characterization of LASS3 and LASS3-long are reported.

Ceramide Synthase 3 (CERS3) Protein Überblick

Protein Überblick

Mediates resistance to sphinganine-analog mycotoxins (SAMs) by restoring the sphingolipid biosynthesis. Could salvage the transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi apparatus in ceramides-depleted cells after SAM exposure (By similarity).

Genbezeichner und Symbole assoziert mit Ceramide Synthase 3 Proteine (CERS3)

  • ceramide synthase 3 (CERS3)
  • LAG1 longevity assurance-like protein (LAG13)
  • ceramide synthase 3 S homeolog (cers3.S)
  • ceramide synthase 3 (Cers3)
  • 4930550L11Rik Protein
  • ARCI9 Protein
  • F13B4.7 Protein
  • F13B4_7 Protein
  • Gm488 Protein
  • LAG1 longevity assurance homolog 3 Protein
  • Lass3 Protein
  • RGD1564356 Protein
  • T3L Protein

Bezeichner auf Proteinebene für Ceramide Synthase 3 Proteine (CERS3)

LAG1 longevity assurance homolog 3 , LAG1 homolog, ceramide synthase 3 , longevity assurance homolog 3 , related to TRH3

GENE ID SPEZIES
453683 Pan troglodytes
837919 Arabidopsis thaliana
444162 Xenopus laevis
426648 Gallus gallus
204219 Homo sapiens
607925 Canis lupus familiaris
614354 Bos taurus
545975 Mus musculus
499174 Rattus norvegicus
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