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CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. Zusätzlich bieten wir Ihnen CDC20 Antikörper (263) und CDC20 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Long non-coding RNA SPRY4 (zeige SPRY4 Proteine)-IT1 (zeige HAUS3 Proteine) promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells
Cdc20 functions as an important negative regulator of SMAR1 (zeige BANP Proteine) in higher grades of cancer
Data provide support for the recent structure-based models and functionally dissect three elements of Cdc20 inhibition: sequestration of Cdc20 in the core mitotic checkpoint (zeige BUB3 Proteine) complex, sufficient at low Cdc20 concentrations; inhibition of a second Cdc20 through the Mad3 (zeige SMAD3 Proteine) C terminus, independent of Mad2 (zeige MAD2L1 Proteine) binding to this Cdc20 molecule; and occupancy of the APC (zeige APC Proteine)/C with full MCC (zeige MCC Proteine), where Mad3 (zeige SMAD3 Proteine) and Apc15 (zeige ANAPC15 Proteine) are involved.
CDC20 gene, related to cell proliferation in protein complex A, might play momentous roles in the initiation and development of consecutive Trauma-Induced Sepsis.
A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A (zeige PPP2R4 Proteine)(B56), modulates APC (zeige APC Proteine)/C(Cdc20) assembly.
c-Myc (zeige MYC Proteine) is a driver when combined with kRas/Akt3 (zeige AKT3 Proteine) oncogenic signals in gliomagenesis, whereas Cdc20 overexpression is a passenger
The ABBA (zeige MTSS1L Proteine)-KEN-ABBA (zeige MTSS1L Proteine) amino acid motif cassette holds the Mitotic Checkpoint (zeige BUB3 Proteine) Complex (MCC (zeige MCC Proteine)) onto the Anaphase-Promoting Complex-Cyclosome (APC (zeige APC Proteine)/C) by binding the two Cdc20 molecules in the MCC (zeige MCC Proteine)-APC (zeige APC Proteine)/C complex.
It discuses the roles of Cdc20 in SAC (zeige ADCY10 Proteine) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.
Prostate cancer-derived SPOP mutants failed to interact with Cdc20 to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 expression became resistant to a pharmacological Cdc20 inhibitor.
High CDC20 expression is associated with metastatic castration-resistant prostate cancer growth and reduces chemosensitivity .
Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.
Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.
A role for the fizzy/cdc20 family of proteins in activation of the APC (zeige APC Proteine)/C distinct from substrate recruitment is reported.
Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.
The physiologically effective threshold level of Cdc20 is high for female meiosis I.
Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (zeige APC Proteine)/C.
The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells
Data suggest that Mad2 (zeige MXI1 Proteine) and BubR1 (zeige BUB1B Proteine) must cooperate to inhibit Cdc20 activity.
Cdc20 is degraded through two independent degradation signals (degrons), the KEN box and a newly described CRY (zeige CRY2 Proteine) box.
Cdc20 and securin (zeige PTTG1 Proteine) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (zeige PTTG1 Proteine) in preventing mitotic exit
Expression of the cdc20 gene is down-regulated by zif268 (zeige EGR1 Proteine) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (zeige EGR1 Proteine) induction may be a key component of long-lasting CNS plasticity.
Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes
findings suggest a novel function of HSF1 (zeige HSF1 Proteine) frequently overexpressed in cancer cells, to inhibit APC (zeige APC Proteine)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability
porcine FZR1 (zeige FZR1 Proteine) and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1
CDC20 appears to act as a regulatory protein interacting with several other proteins at multiple points in the cell cycle. It is required for two microtubule-dependent processes, nuclear movement prior to anaphase and chromosome separation.
cell division cycle 20 homolog
, CDC20 cell division cycle 20 homolog
, cell division cycle protein 20 homolog
, cell cycle protein p55CDC