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Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Zusätzlich bieten wir Ihnen CCAR2 Antikörper (51) und viele weitere Produktgruppen zu diesem Protein an.
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CCAR2/DBC1 inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP (zeige RBBP8 Proteine).
conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC (zeige FAM126A Proteine).
Long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 (zeige TP53 Proteine) acetylation.
Data suggest that DBC1 has a dual function in regulating beta-catenin (zeige CTNNB1 Proteine)-PROX1 (zeige PROX1 Proteine) signaling axis: as a coactivator for both beta-catenin (zeige CTNNB1 Proteine) and PROX1 (zeige PROX1 Proteine).
important role for CCAR2 in maintaining cell cycle progression and promoting squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)) tumorigenesis.
Data show that the interaction between cell cycle and apoptosis regulator 2 (CCAR2) and heat shock protein 60 (Hsp60 (zeige HSPD1 Proteine)) increases in the presence of rotenone.
Results found transcriptional levels of DBC1,a negative regulator of HDAC3 (zeige HDAC3 Proteine) significantly reduced in type 2 diabetes mellitus patients.
DBC1 protein could be a prognostic marker of shorter recurrence-free survival in hepatocellular carcinoma patients after hepatectomy and human hepatocarcinogenesis was a multistep process accompanied by a stepwise increase in high DBC1 expression from low-grade dysplastic nodules, through high-grade dysplastic nodules, to hepatocellular carcinoma.
Results suggest that DBC1 is integral to the maintenance of the circadian molecular clock.
loss of DBC1 expression plays a role in tumorigenesis and tumor progression in gallbladder carcinoma.
Dbc1 ablation increases Scd1 (zeige SCD Proteine) levels, causes obesity and insulin (zeige INS Proteine) resistance.
phosphorylation of DBC1 at its C terminus by IKKalpha (zeige CHUK Proteine) facilitates its interaction with RelB (zeige RELB Proteine) and IKKalpha (zeige CHUK Proteine), indicating that DBC1-mediated suppression of alternative NF-kappaB (zeige NFKB1 Proteine) is regulated by IKKalpha (zeige CHUK Proteine).
induced the expression of nuclear factor kappa B (NF-kappaB (zeige NFKB1 Proteine))-regulated inflammatory cytokines in fully differentiated 3T3-L1 adipocytes, possibly through the inhibition of Sirt1 (zeige SIRT1 Proteine) activity
We propose that DBC1 is part of the molecular machinery that regulates fat storage capacity in adipocytes and participates in the "turn-off" switch that limits adipocyte fat accumulation.
DBC1 as a novel regulator of gluconeogenesis.
HDAC3 is negatively regulated by the nuclear protein DBC1
New role for DBC1 as an in vivo regulator of SIRT1 (zeige SIRT1 Proteine) activity and liver steatosis, in which interaction with SIRT1 (zeige SIRT1 Proteine) may serve as a new target for therapies aimed at nonalcoholic liver steatosis.
Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.
DBIRD complex subunit KIAA1967
, deleted in breast cancer 1
, p30 DBC protein
, DBIRD complex subunit KIAA1967 homolog
, cell cycle and apoptosis regulator protein 2