Cell Cycle and Apoptosis Regulator 2 Proteine (CCAR2)

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Zusätzlich bieten wir Ihnen CCAR2 Antikörper (53) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CCAR2 57805 Q8N163
CCAR2 219158 Q8VDP4
Ratte CCAR2 CCAR2 306007  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 11 Days
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
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CCAR2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Cell Cycle and Apoptosis Regulator 2 (CCAR2) Interaktionspartnern

Human Cell Cycle and Apoptosis Regulator 2 (CCAR2) Interaktionspartner

  1. Since its up-regulation in cancer patients is usually associated with poor prognosis and its depletion reduces cancer cell growth in vitro, CCAR2 was suggested to act as a tumor promoter. However, there is also evidence that CCAR2 functions as a tumor suppressor and therefore its role in cancer formation and progression is still unclear. Review.

  2. CCAR2/DBC1 inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP.

  3. conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC.

  4. Long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 acetylation.

  5. Data suggest that DBC1 has a dual function in regulating beta-catenin-PROX1 signaling axis: as a coactivator for both beta-catenin and PROX1.

  6. These results establish an important role for CCAR2 in cancer cells proliferation and could shed new light on novel therapeutic strategies against cancer, devoid of detrimental side effects.

  7. important role for CCAR2 in maintaining cell cycle progression and promoting squamous cell carcinoma (SCC) tumorigenesis.

  8. Data show that the interaction between cell cycle and apoptosis regulator 2 (CCAR2) and heat shock protein 60 (Hsp60) increases in the presence of rotenone.

  9. Results found transcriptional levels of DBC1,a negative regulator of HDAC3 significantly reduced in type 2 diabetes mellitus patients.

  10. DBC1 protein could be a prognostic marker of shorter recurrence-free survival in hepatocellular carcinoma patients after hepatectomy and human hepatocarcinogenesis was a multistep process accompanied by a stepwise increase in high DBC1 expression from low-grade dysplastic nodules, through high-grade dysplastic nodules, to hepatocellular carcinoma.

  11. Results suggest that DBC1 is integral to the maintenance of the circadian molecular clock.

  12. loss of DBC1 expression plays a role in tumorigenesis and tumor progression in gallbladder carcinoma.

  13. Proteosome-mediated degradation and poly-ubiquitination of AR were increased with the knock-down of DBC1.

  14. These studies further extend and confirm the role of CCAR2 in the DNA damage response and DNA repair

  15. The results suggest that the PP4-mediated dephosphorylation of DBC1 is necessary for efficient damage responses in cells.

  16. These results indicate that the expression of DBC1 and BRCA1 are closely related with in the progression of ovarian carcinomas

  17. the results indicated that DBC1 promotes anoikis resistance in gastric cancer cells by regulating NF-kappaB activity and may thus be a new therapeutic target for preventing potential metastasis

  18. DBC1 modification by Small Ubiquitin-like Modifier 2/3 is crucial for p53 transactivation under genotoxic stress.

  19. molecular mechanism underlying DBC1 function in PEA3-mediated transcription involves inhibition of SIRT1 interaction with PEA3 and of SIRT1-mediated deacetylation of PEA3

  20. DBC1 might promote adipose tissue inflammation and senescence in obese subjects

Mouse (Murine) Cell Cycle and Apoptosis Regulator 2 (CCAR2) Interaktionspartner

  1. Dbc1 ablation increases Scd1 levels, causes obesity and insulin resistance.

  2. phosphorylation of DBC1 at its C terminus by IKKalpha facilitates its interaction with RelB and IKKalpha, indicating that DBC1-mediated suppression of alternative NF-kappaB is regulated by IKKalpha.

  3. induced the expression of nuclear factor kappa B (NF-kappaB)-regulated inflammatory cytokines in fully differentiated 3T3-L1 adipocytes, possibly through the inhibition of Sirt1 activity

  4. We propose that DBC1 is part of the molecular machinery that regulates fat storage capacity in adipocytes and participates in the "turn-off" switch that limits adipocyte fat accumulation.

  5. DBC1 as a novel regulator of gluconeogenesis.

  6. deleted in breast cancer 1 (DBC1)provides a signaling mechanism that controls chromatin remodeling in an inflammatory response.

  7. HDAC3 is negatively regulated by the nuclear protein DBC1

  8. New role for DBC1 as an in vivo regulator of SIRT1 activity and liver steatosis, in which interaction with SIRT1 may serve as a new target for therapies aimed at nonalcoholic liver steatosis.

CCAR2 Protein Überblick

Protein Überblick

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.

Genbezeichner und Symbole assoziert mit CCAR2

  • cell cycle and apoptosis regulator 2 (CCAR2)
  • cell cycle activator and apoptosis regulator 2 (Ccar2)
  • cell cycle and apoptosis regulator 2 (Ccar2)
  • 2610301G19Rik Protein
  • DBC-1 Protein
  • DBC1 Protein
  • Kiaa1967 Protein
  • mKIAA1967 Protein
  • NET35 Protein
  • p30 DBC Protein
  • p30DBC Protein
  • RGD1309922 Protein

Bezeichner auf Proteinebene für CCAR2

DBIRD complex subunit KIAA1967 , deleted in breast cancer 1 , p30 DBC protein , DBIRD complex subunit KIAA1967 homolog , cell cycle and apoptosis regulator protein 2

GENE ID SPEZIES
57805 Homo sapiens
219158 Mus musculus
306007 Rattus norvegicus
486122 Canis lupus familiaris
100155718 Sus scrofa
100730691 Cavia porcellus
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