Cell Cycle and Apoptosis Regulator 2 Proteine (CCAR2)

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Zusätzlich bieten wir Ihnen CCAR2 Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CCAR2 57805 Q8N163
CCAR2    
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details

CCAR2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Cell Cycle and Apoptosis Regulator 2 (CCAR2) Interaktionspartnern

Human Cell Cycle and Apoptosis Regulator 2 (CCAR2) Interaktionspartner

  1. CCAR2/DBC1 inhibits recombination by limiting the initiation and the extent of DNA end resection, thereby acting as an antagonist of CtIP (zeige RBBP8 Proteine).

  2. conclude, these findings demonstrated that DBC1 was essential in tumorigenesis and proliferation. Moreover, it was identified as a potential therapeutic target for HCC (zeige FAM126A Proteine).

  3. Long non-coding RNA MALAT1 interacts with DBC1 to regulate p53 (zeige TP53 Proteine) acetylation.

  4. Data suggest that DBC1 has a dual function in regulating beta-catenin (zeige CTNNB1 Proteine)-PROX1 (zeige PROX1 Proteine) signaling axis: as a coactivator for both beta-catenin (zeige CTNNB1 Proteine) and PROX1 (zeige PROX1 Proteine).

  5. important role for CCAR2 in maintaining cell cycle progression and promoting squamous cell carcinoma (SCC (zeige CYP11A1 Proteine)) tumorigenesis.

  6. Data show that the interaction between cell cycle and apoptosis regulator 2 (CCAR2) and heat shock protein 60 (Hsp60 (zeige HSPD1 Proteine)) increases in the presence of rotenone.

  7. Results found transcriptional levels of DBC1,a negative regulator of HDAC3 (zeige HDAC3 Proteine) significantly reduced in type 2 diabetes mellitus patients.

  8. DBC1 protein could be a prognostic marker of shorter recurrence-free survival in hepatocellular carcinoma patients after hepatectomy and human hepatocarcinogenesis was a multistep process accompanied by a stepwise increase in high DBC1 expression from low-grade dysplastic nodules, through high-grade dysplastic nodules, to hepatocellular carcinoma.

  9. Results suggest that DBC1 is integral to the maintenance of the circadian molecular clock.

  10. loss of DBC1 expression plays a role in tumorigenesis and tumor progression in gallbladder carcinoma.

CCAR2 Protein Überblick

Protein Überblick

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.

Genbezeichner und Symbole assoziert mit CCAR2

  • cell cycle and apoptosis regulator 2 (CCAR2)
  • DBC-1 Protein
  • DBC1 Protein
  • KIAA1967 Protein
  • NET35 Protein
  • p30 DBC Protein
  • p30DBC Protein

Bezeichner auf Proteinebene für CCAR2

DBIRD complex subunit KIAA1967 , deleted in breast cancer 1 , p30 DBC protein

GENE ID SPEZIES
57805 Homo sapiens
Ausgewählte Anbieter für CCAR2 Proteine (CCAR2)
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