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Involved in the cell-cell adhesion.
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Mammalian Monoclonal Cell Adhesion Molecule 4 Primary Antibody für ISt, IHC - ABIN1304992
Yamana, Tokiyama, Mizutani, Hirata, Takai, Rikitake: The Cell Adhesion Molecule Necl-4/CADM4 Serves as a Novel Regulator for Contact Inhibition of Cell Movement and Proliferation. in PLoS ONE 2015
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Human Polyclonal Cell Adhesion Molecule 4 Primary Antibody für IHC (p), IHC - ABIN314266
Spiegel, Adamsky, Eshed, Milo, Sabanay, Sarig-Nadir, Horresh, Scherer, Rasband, Peles: A central role for Necl4 (SynCAM4) in Schwann cell-axon interaction and myelination. in Nature neuroscience 2007
Cell adhesion molecule 4 (cadm4) is essential for restricting the size of the zebrafish cardiac outflow tract.
There was a significant association between RNase 5 (zeige ANG Antikörper) and histological differentiation in colon adenocarcinomas, but no association between RNase 5 (zeige ANG Antikörper) and Necl 4 in gastric or colon adenocarcinomas
Low CADM4 expression is associated with bone marrow metastasis in neuroblastoma (zeige ARHGEF16 Antikörper).
The results suggest that Necl-4 enhances VEGF (zeige VEGFA Antikörper)-induced activation of PLCgamma-c-Raf (zeige RAF1 Antikörper)-MEK (zeige MAP2K1 Antikörper)-ERK (zeige EPHB2 Antikörper) pathway without affecting the phosphorylation and internalization of VEGFR2 (zeige KDR Antikörper).
Necl-4 serves as a novel regulator for contact inhibition of cell movement and proliferation cooperatively with the VEGF receptor and PTPN13
results indicate that Necl-4 serves as a tumor suppressor by inhibiting the ErbB2 (zeige ERBB2 Antikörper)/ErbB3 (zeige ERBB3 Antikörper) signaling and hemidesmosome disassembly
Loss or decrease of CADM4 expression seems to play an important role in breast cancer invasiveness, and it is associated with poorer biological parameters.
Cadm4 regulates the growth of the myelin unit and the organization of the underlying axonal membrane.
CADM4, as well as 4.1B (zeige EPB41L3 Antikörper) is expressed specifically in human proximal tubules.
TSLL2 is expressed at the cell-cell attachment sites in the renal tubules, the transitional epithelia of the bladder, and the glandular epithelia of the prostate, and is a tumor-suppressor candidate in prostate cancer.
Necl-4 is dispensable for axonal myelination in the developing nervous system.
findings imply that 4.1G plays a role in spermatogenesis by mediating cell-cell adhesion between spermatogenic and Sertoli cells through its interaction with NECL4 on Sertoli cells
Involved in the cell-cell adhesion. Has calcium- and magnesium-independent cell-cell adhesion activity. May have tumor- suppressor activity (By similarity).
cell adhesion molecule 4
, immunoglobulin superfamily, member 4C
, cell adhesion molecule 4-like
, TSLC1-like 2
, TSLC1-like protein 2
, immunoglobulin superfamily member 4C
, nectin-like 4
, nectin-like protein 4
, SynCAM 4
, membrane glycoprotein Tsll2
, urokinase plasminogen activator receptor