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CTDSPL encodes an essential structural component of the synaptonemal complex. Zusätzlich bieten wir Ihnen und und viele weitere Produktgruppen zu diesem Protein an.
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our data also suggests the importance ofLIMD1 and CDC25A in conjunction with HPV for use as diagnostic and prognostic markers of HNSCC, whereas RBSP3 as a prognostic marker only.
data suggest that overexpression of p-RB1 in basal-parabasal layers of normal cervical epithelium was due to methylation/low functional-linked non-synonimous SNPs of P16 and RBSP3. This pattern was maintained during cervical carcinogenesis by additional deletion/mutation
CTDSPL and Rb directly interact and can be involved in the common mechanism of cell cycle regulation.
identified RBSP3, a phosphatase-like tumor suppressor, as a bona fide target of miR-100 and validated that RBSP3 was involved in cell differentiation and survival in acute myeloid leukemia
tumor suppressor genes RBSP3/CTDSPL, NPRL2/G21 and RASSF1A are downregulated in primary non-small cell lung cancer
dysregulation of hMLH1, ITGA9, and RBSP3 associated multiple cellular pathways are needed for the development of early dysplastic lesions of the head and neck.
In cervical intraepithelial neoplasms and uterine cervical carinoma, RBSP3 is oftne deletd, compared with other genes.
analysis of RBSP3/HYA22located in the AP20 region, and evidence for tumor suppressor function
SCP3 acts as a phosphatase for regulatory phosphorylations in the linker regions of Smad1 and Smad2.
Frequent alterations of RBSP3 at chromosomal 3p22.3 region in early and late-onset breast carcinoma are reported with reference to clinical and prognostic significance.
Down-regulation of RBSP3/CTDSPL, NPRL2/G21, RASSF1A, ITGA9, HYAL1 and HYAL2 genes in non-small cell lung cancer
This is the first report of high frequencies of somatic mutations in RASSF1 and RBSP3 in different cancers suggesting it may underlay the mutator phenotype of cancer.
R-Smads are the key components of TGFbeta beta signals in germ layer induction. SCP3 serves as a vegetally enriched, intrinsic factor to ensure a prepared status of Smads for their activation.
This gene encodes an essential structural component of the synaptonemal complex. This complex is involved in synapsis, recombination and segregation of meiotic chromosomes. Mutations in this gene are associated with azoospermia in males and susceptibility to pregnancy loss in females. Alternate splicing results in multiple transcript variants that encode the same protein.
CTD small phosphatase-like protein
, NIF-like protein
, NLI-interacting factor 1
, RB protein serine phosphatase from chromosome 3
, carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 3
, nuclear LIM interactor-interacting factor 1
, small C-terminal domain phosphatase 3
, small CTD phosphatase 3
, small CTD phosphatase 3-like
, NLI/Ldb1/CLIM interacting factor
, CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
, CTD small phosphatase like L homeolog
, CTD small phosphatase like S homeolog