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Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity)..
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a comprehensive current understanding into the molecular mechanisms of CARF functions in regulation of DNA damage response, cell cycle checkpoints, cell survival and death signaling pathways.
report that CARF (Collaborator of ARF) is a new target of miR (zeige MLXIP ELISA Kits)-335 that regulates its growth suppressor function by complex crosstalk with other proteins including p16(INK4A), pRB (zeige RB1 ELISA Kits), HDM2 and p21(WAF1 (zeige CDKN1A ELISA Kits))
Oncogenic functions of CARF in hepatocellular carcinoma tumorigenesis is a result of activation of beta-catenin (zeige CTNNB1 ELISA Kits)/TCF (zeige HNF4A ELISA Kits) signaling.
CARF promotes carcinogenesis in p53 (zeige TP53 ELISA Kits)-deficient cells by repressing p21WAF1 and promoting cell cycle progression.
The results suggest that CARF regulates early steps of pre-rRNA processing during ribosome biogenesis by controlling spatial distribution of XRN2 (zeige XRN2 ELISA Kits) between the nucleoplasm and nucleolus.
CARF regulates proliferative fate of human cells by dose-dependent regulation of DNA damage signaling.
Analysis of indel variations in the human disease-associated genes CDKN2AIP, WDR66, USP20 and OR7C2 (zeige OR7C2 ELISA Kits) in a Korean population.
CARF knockdown elicited DNA damage response as evidenced by increased levels of phosphorylated ATM (zeige ATM ELISA Kits) and gammaH2AX (zeige H2AFX ELISA Kits), leading to induction of mitotic arrest and eventual apoptosis.
CARF may act as a novel key regulator of the p53 (zeige TP53 ELISA Kits) pathway at multiple checkpoints
cooperates with human p14ARF in activating p53 (zeige TP53 ELISA Kits)
Activates p53/TP53 by CDKN2A-dependent and CDKN2A- independent pathways (By similarity).
, collaborates/cooperates with ARF (alternate reading frame) protein
, collaborator of ARF
, amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 8
, amyotrophic lateral sclerosis 2 chromosomal region candidate gene 8 protein
, calcium-response factor
, calcium-responsive transcription factor
, testis development protein NYD-SP24
, CDKN2A interacting protein
, protein CDKN2AIP homolog A