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Ubiquitous transcription factor required for a diverse set of processes. Zusätzlich bieten wir Ihnen CNOT8 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Pharmacological inhibition of FGF signaling or a mutation in the fgf3 (zeige FGF3 Antikörper) gene can compensate the gain of caudal (zeige CAD Antikörper) hypothalamic dopaminergic neurons in cnot8m1061 mutants, indicating a role for Fgf3 (zeige FGF3 Antikörper) in control of development of this dopaminergic population
These results indicate that Caf1 (zeige CHAF1B Antikörper) and Ccr4 (zeige CCR4 Antikörper) cooperate in mRNA deadenylation and suggest that the enzyme activities of Caf1 (zeige CHAF1B Antikörper) and Ccr4 (zeige CCR4 Antikörper) are regulated via allosteric interactions within the nuclease (zeige DCLRE1C Antikörper) module.
CNOT7 (zeige CNOT7 Antikörper)/hCAF1 is involved in ICAM-1 (zeige ICAM1 Antikörper) and IL-8 (zeige IL8 Antikörper) regulation by TTP (zeige ADAMTS13 Antikörper) in HPMEC.
show that SMG7 binds directly to POP2, a catalytic subunit of the CCR4 (zeige CCR4 Antikörper)-NOT deadenylase complex, and elicits deadenylation-dependent decapping and 5'-to-3' decay of NMD targets
The anti-proliferative activity of BTG/TOB (zeige TDO2 Antikörper) proteins is mediated via the Caf1a (zeige CHAF1B Antikörper) (CNOT7 (zeige CNOT7 Antikörper)) and Caf1b (zeige CHAF1A Antikörper) (CNOT8) deadenylase subunits of the Ccr4 (zeige CCR4 Antikörper)-not complex.
The NOT1 MIF4G domain binds CAF1 through a pre-formed interface and leaves the CAF1 catalytic site fully accessible to RNA substrates.
N-terminus played a role in modulating hCaf1 activity, stability and aggregation
Together, these results indicate that Tob (zeige TDO2 Antikörper) mediates the recruitment of Caf1 (zeige CHAF1B Antikörper) to the target of CPEB3 (zeige CPEB3 Antikörper) and elicits deadenylation and decay of the mRNA.
MK2 (zeige KCNA2 Antikörper) phosphorylation reduces the ability of TTP (zeige ADAMTS13 Antikörper) to promote deadenylation by inhibiting the recruitment of CAF1 (zeige CHAF1B Antikörper) deadenylase in a mechanism that does not involve sequestration of TTP (zeige ADAMTS13 Antikörper) by 14-3-3 (zeige YWHAQ Antikörper).
Tob (zeige TDO2 Antikörper) interactions with Caf1 (zeige CHAF1B Antikörper) and a C-terminal domain of PABPC1 (zeige PABPC1 Antikörper)
CCR4 (zeige CCR4 Antikörper)-NOT is the deadenylase that removes poly(A) from messages destabilized by miRNAs in human cells.
study reports that a complex of BTG4 and CAF1 safeguards metaphase II arrest in mammalian eggs by deadenylating maternal mRNAs
Ubiquitous transcription factor required for a diverse set of processes. The CCR4-NOT complex functions as general transcription regulation complex (By similarity).
CCR4-NOT transcription complex subunit 8 , CCR4-NOT transcription complex, subunit 8 , ccr4-not transcription complex subunit 8 , CAF1-like protein , CAF2 , CALIFp , CCR4-associated factor 8 , PGK promoter directed over production