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CTCF is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains.
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Human Monoclonal CTCF Primary Antibody für ELISA, WB - ABIN969071
Grbesa, Marinkovic, Ivkic, Kruslin, Novak-Kujundzic, Pegan, Bogdanovic, Bedekovic, Gall-Troselj: Loss of imprinting of IGF2 and H19, loss of heterozygosity of IGF2R and CTCF, and Helicobacter pylori infection in laryngeal squamous cell carcinoma. in Journal of molecular medicine (Berlin, Germany) 2008
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Human Polyclonal CTCF Primary Antibody für IP - ABIN153008
Lai, Fatemi, Dhasarathy, Malone, Sobol, Geigerman, Jaye, Mav, Shah, Li, Wade: DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. in The Journal of experimental medicine 2010
Human Monoclonal CTCF Primary Antibody für ELISA, WB - ABIN965942
Majumder, Gomez, Chadwick, Boss: The insulator factor CTCF controls MHC class II gene expression and is required for the formation of long-distance chromatin interactions. in The Journal of experimental medicine 2008
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Human Polyclonal CTCF Primary Antibody für ChIP, ICC - ABIN4300770
Martínez, Cruz, Lu, Plasschaert, Deng, Rivera-Molina, Bartolomei, Lieberman, Tang: CTCF binding to the first intron of the major immediate early (MIE) gene of human cytomegalovirus (HCMV) negatively regulates MIE gene expression and HCMV replication. in Journal of virology 2014
Human Polyclonal CTCF Primary Antibody für ChIPSeq, ChIP - ABIN2668282
Moriguchi, Yu, Takai, Hayashi, Satoh, Suzuki, Ohneda, Yamamoto: The Human GATA1 Gene Retains a 5' Insulator That Maintains Chromosomal Architecture and GATA1 Expression Levels in Splenic Erythroblasts. in Molecular and cellular biology 2015
We propose that cohesin and CTCF have distinct functions in the regulation of runx1 (zeige RUNX1 Antikörper) during zebrafish embryogenesis.
Data conclude that CTCF modulates MRF (zeige C11orf9 Antikörper) functional interactions in the orchestration of myogenesis.
CCCTC-binding factor CTCF supports the homeostatic maintenance of hematopoietic stem cell (HSCs) pools by sustaining HSC (zeige FUT1 Antikörper) quiescence in a reactive oxygen species ROS (zeige ROS1 Antikörper)-dependent manner.
Authors show that mice devoid of an inducible CTCF binding element, located in the alpha constant gene, display a marked isotype-specific increase of GL transcription in developing and resting splenic B cells and altered CSR (zeige SCARA3 Antikörper) in activated B cells.
The study provides evidence that CTCF regulates chromatin organization during spermiogenesis, contributing to the functional organization of mature sperm.
CTCF Binding Sites in the Herpes Simplex Virus 1 Genome Display Site-Specific CTCF Occupation, Protein Recruitment, and Insulator Function.
Both LDB1 (zeige LDB1 Antikörper) and CTCF are required for enhancer-Car2 (zeige CA2 Antikörper) looping, and the domain of LDB1 (zeige LDB1 Antikörper) contacted by CTCF is necessary to rescue Car2 (zeige CA2 Antikörper) transcription in LDB1 (zeige LDB1 Antikörper)-deficient cells.
CTCF physically associates with Wdr5 (zeige WDR5 Antikörper) and further transcriptionally controls its expression by directly targeting the Wdr5 (zeige WDR5 Antikörper) gene promoter.
Since CTCF and cohesin are required for loop domain formation, our results suggest that chromatin loops are dynamic and frequently break and reform throughout the cell cycle.
Nearly half of all DNase (zeige DNASE2 Antikörper) hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 (zeige RUNX2 Antikörper) and/or the chromatin-related CTCF transcription factors.
Chromatin immunoprecipitation-DNA sequence analysis was performed in adult cerebellum and Wiz (zeige ZNF803 Antikörper) peaks were found at promoters and transcription factor CTCF binding sites.
CTCF knockdown attenuates fear-conditioning-induced hippocampal gene expression of key learning genes and loss of long-range interactions at the BDNF (zeige BDNF Antikörper) and Arc (zeige NOL3 Antikörper) loci.
This study confirms that haploinsufficiency of CTCF causes distinct clinical features, and that a microdeletion encompassing CTCF could cause a recognisable CTCF deletion syndrome. Perturbed DNA methylation (zeige HELLS Antikörper) at CTCF binding sites, not at imprinted loci, may underlie the pathomechanism of the syndrome.
structural studies show that the sequence-specific interactions between zinc fingers and CTCF-binding sites determine the directionality and conservation of CTCF recognition.
CTCF may be a key factor that contributes to gene co-mutations in cancer.
results support a model in which YY1 (zeige YY1 Antikörper) acts as an architectural protein to connect developmentally regulated looping interactions; the location of YY1 (zeige YY1 Antikörper)-mediated interactions may be demarcated in development by a preexisting topological framework created by constitutive CTCF-mediated interactions.
The MeCP2, a protein whose mutated forms are involved in Rett syndrome; and CTCF, a constitutive transcriptional insulator.
The results show that cohesin has an essential genome-wide function in mediating long-range chromatin interactions and support the hypothesis that cohesin creates these by loop extrusion, until it is delayed by CTCF in a manner dependent on PDS5 proteins, or until it is released from DNA by WAPL (zeige WAPAL Antikörper).
CTCF-FOXM1 (zeige FOXM1 Antikörper) axis regulates tumour growth and metastasis in hepatocellular carcinoma cells.
we show CTCF binding site mutations to be functional by demonstrating allele-specific reduction of CTCF binding to mutant alleles. While topologically associating domains with mutated CTCF anchors in melanoma contain differentially expressed cancer-associated genes, CTCF motif mutations appear generally under neutral selection
CTCF-mediated long-range interactions are integral for a multitude of topological features of interphase chromatin, such as the formation of topologically associated domains, domain insulation, enhancer blocking and even enhancer function.
Authors have identified two novel pro-tumorigenic roles (promoting cell survival and altering cell polarity) for genetic alterations of CTCF in endometrial cancer.
This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
transcriptional repressor CTCF
, CCCTC-binding factor (zinc finger protein)
, transcriptional repressor CTCF-like
, 11-zinc finger protein
, CTCFL paralog
, 11 zinc finger transcriptional repressor