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BLOC1S2 encodes a protein with multiple functions.
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BLOS2 physically interacted with Notch1 (zeige NOTCH1 Antikörper) in endo-lysosomal trafficking of Notch1 (zeige NOTCH1 Antikörper). The findings suggest that BLOS2 is a novel negative player in regulating Notch (zeige NOTCH1 Antikörper) signaling through lysosomal trafficking to control multiple stem and progenitor cell homeostasis in vertebrates.
These findings reveal that balanced control of Notch (zeige NOTCH1 Antikörper) signaling by BLOS2 is required for HSC (zeige FUT1 Antikörper) homeostasis during fetal liver hematopoiesis.
SLX2 might get involved in chromosomes segregation during meiosis by interaction with BLOS2.
WASH is a bimodular protein and a component of the BLOC-1 complex in which the C terminus is involved in Arp2/3-mediated actin nucleation, whereas the N-terminal portion is required for its regulation and localization in the cells
Mutations in the human genes encoding Snapin and the BLOS proteins could underlie nov (zeige PLDN Antikörper)el forms of Hermansky-Pudlak syndrome as seen in mouse models
BLOC1S2 protein is widely expressed in normal tissue as well as in malignant tumors with a tendency towards lower expression levels in certain subtypes of tumors. Over-expression of BLOC1S2 in the presence or absence of HIPPI (zeige IFT57 Antikörper) does not induce apoptosis.
we have explored ways of efficiently gathering high-quality information about candidate binding partners fob bloc1s2
Biogenesis of lysosome-related organelles complex-1 (BLOC-1) subunit 2 (BLOS2).BLOC-1 (zeige BLOC1S1 Antikörper) is required for the biogenesis of melanosomes and platelet dense granules.
This gene encodes a protein with multiple functions. The encoded protein has been found in association with the centrosome, shown to co-localize with gamma-tubulin, and also found to be one of the proteins in the BLOC-1 complex which functions in the formation of lysosome-related organelles. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants.
BLOC-1 subunit 2
, biogenesis of lysosome-related organelles complex 1 subunit 2
, biogenesis of lysosome-related organelles complex-1, subunit 2A
, centrosomal 10 kDa protein
, centrosome protein oncogene
, centrosome-associated protein
, BLOC1S2 isoform
, biogenesis of lysosome-related organelles complex-1 subunit 2
, biogenesis of lysosome-related organelles complex-1, subunit 2
, spinal cord-expressed protein 1
, biogenesis of lysosomal organelles complex-1, subunit 2 L homeolog
, biogenesis of lysosome-related organelles complex-1 subunit 2-like