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BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. Zusätzlich bieten wir Ihnen BLOC1S1 Antikörper (17) und BLOC1S1 Kits (13) und viele weitere Produktgruppen zu diesem Protein an.
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Using cancer cell lines, the study shows that BLOC1S1 mRNA is specifically cleaved by IRE1 (zeige ERN1 Proteine) at guanine 444, but only under conditions of IRE1 (zeige ERN1 Proteine) hyperactivation.
The Hermansky-Pudlak syndrome complex BLOC-1 and its cargo PI4KIIalpha interact with regulators of the actin cytoskeleton.
BLOS1 interacts with KXD1.
GCN5L1/BLOC1S1 regulates lysine acetylation in mitochondria.
Quantitative proteomic studies expand the functional repertoire of the BLOC-1 complex and provide insight into putative molecular pathways of schizophrenia susceptibility.
Together this study data provide evidence for the involvement of the BLOC-1 protein complex in SZ pathogenesis.
Experimental investigation of five specific genes, AP3B1 (zeige AP3B1 Proteine), ATP6AP1 (zeige ATP6AP1 Proteine), BLOC1S1, LAMP2 (zeige LAMP2 Proteine), and RAB11A (zeige RAB11A Proteine), has confirmed novel roles for these proteins in the proper initiation of macroautophagy in amino acid-starved fibroblasts.
Biogenesis of Lysosome-related Organelles co (zeige SNAPIN Proteine)mplex-1 (BLOC-1) subunit 1 (BLOS1).
Data show that the mitochondrial enriched GCN5 (zeige KAT2A Proteine)-like 1 protein (GCN5L1) controls hepatic glucose production by regulating FoxO1 (zeige FOXO1 Proteine) protein levels.
Acetylation of cardiac mitochondrial fatty acid oxidation enzymes by GCN5L1 significantly upregulates their activity in diet-induced obese mice.
TDH, responsible for mitochondrial production of acetyl-CoA (zeige LPCAT1 Proteine) in mouse embryonic stem cells, and the acetyltransferase GCN5L1 cooperate to acetylate Lys501 in KBP, allowing its recognition by and degradation via Fbxo15 (zeige FBXO15 Proteine), an F-box protein (zeige FBXO30 Proteine) transcriptionally controlled by the pluripotency core factors and repressed following differentiation.
BLOS1 interacts with sorting nexin 2 (zeige SNX2 Proteine) and the ESCRT-I (zeige VPS28 Proteine) component TSG101 (zeige TSG101 Proteine) to mediate the sorting of EGFR (zeige EGFR Proteine) into endosomal compartments
Here we show that genetic deletion of GCN5L1 has a direct positive effect on the expression and activity of Transcriptional Factor EB (TFEB (zeige TFEB Proteine)), which acts as a master regulator of autophagy.
Mutations in the human genes encoding Snapin (zeige SNAPIN Proteine) and the BLOS proteins could underlie novel forms of Hermansky-Pudlak syndrome as seen in mouse models
Defects in all the 5 known components of BLOC-1 (zeige PLDN Proteine), including RP, cause severe Hermansky Pudlak syndrome in mice, suggesting that the subunits are nonredundant and that BLOC-1 (zeige PLDN Proteine) plays a key role in organelle biogenesis.
These results indicate that the BLOC-1 (zeige PLDN Proteine) and AP-3 (zeige AP3B1 Proteine) protein complexes affect the targeting of SNARE (zeige VTI1B Proteine) and non-SNARE (zeige VTI1B Proteine) AP-3 (zeige AP3B1 Proteine) cargoes and suggest a function of the BLOC-1 (zeige PLDN Proteine) complex in membrane protein sorting.
BLOC1S1 is a component of the ubiquitously expressed BLOC1 multisubunit protein complex. BLOC1 is required for normal biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules (Starcevic and Dell'Angelica, 2004
BLOC subunit 1
, BLOC-1 subunit 1
, GCN5 (general control of amino-acid synthesis, yeast, homolog)-like 1
, GCN5 general control of amino-acid synthesis 5-like 1
, GCN5-like protein 1
, MTA1-interacting coactivator
, biogenesis of lysosome-related organelles complex 1 subunit 1
, biogenesis of lysosome-related organelles complex-1, subunit 1
, GCN5 general control of amino acid synthesis-like 1
, general control of amino acid synthesis, yeast homolog-like 1
, general control of amino acid synthesis-like 1