BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 Proteine (BACH1)

BACH1 encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). Zusätzlich bieten wir Ihnen BACH1 Antikörper (108) und BACH1 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
BACH1 12013 P97302
BACH1 571 O14867
Ratte BACH1 BACH1 304127  
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,741.67
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$547.80
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$325.44
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BACH1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
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Weitere Proteine zu BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Interaktionspartnern

Zebrafish BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Interaktionspartner

  1. Bach1 regulates the liver specificity and transience of the Nrf2a-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.

  2. The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.

Mouse (Murine) BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Interaktionspartner

  1. Theraputic effects of Pirfenidone for induced pulmonary fibrosis were involved in Nrf2/Bach1 equilibrium which regulated the capacity of oxidative stress.

  2. Data suggest that Abcb10 silencing results in alteration in heme biosynthesis transcriptional profile due to repression by transcriptional regulator Bach1. (Abcb10 = ATP-binding cassette, sub-family B [MDR-TAP], member 10; Bach1 = BTB and CNC homology 1, basic leucine zipper transcription factor 1)

  3. This study showed that RANKL favors osteoclastogenesis via attenuation of Nrf2-mediated antioxidant enzyme expression by competing with Bach1 nuclear accumulation.

  4. this study provides new insight into the function of iron and Bach1 in erythroblast maturation by using efficacious regimens that can induce severe ID.

  5. miR-196a, which binds to the 3'-untranslated region of the transcriptional repressor BTB and CNC homology 1 (Bach1) and regulates its expression, and subsequently leads to higher levels of lung HO-1 mRNA.

  6. Bach1 siRNA exerts protective effects against bleomycin-induced pulmonary fibrosis in mice.

  7. These results suggest that Bach1 and Bach2 work in a complementary manner to maintain the normal function of the AMs and surfactant homeostasis in the lung.

  8. By integrating the chromatin immunoprecipitation and next-generation sequencing data with a comparative analysis of gene expression in Bach1-deficient and wild type immortalized mouse embryonic fibroblasts (iMEFs), study found 35 new genes whose expression was repressed by BACH1. Known functions of some of these genes suggested a role of BACH1 in adipocyte differentiation, which was verified using iMEFs.

  9. Bach1 deficiency reduces the severity of osteoarthritis-like changes. This may be due to maintenance of cartilage homeostasis and joint health by antioxidant effects

  10. Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt/beta-catenin signaling by disrupting the interaction between beta-catenin and TCF4 and by recruiting histone deacetylase 1 to the promoter of TCF4-targeted genes.

  11. Bach1 deficiency and accompanying overexpression of HO-1 did not influence aging or p53 deficiency-driven tumorigenesis.

  12. Our results suggest that Bach2 functions with Bach1 and EBF1 to promote B cell development by repressing myeloid genes in common lymphoid progenitor cells

  13. HO-1 induction after ischemia was associated to down-regulation of transcriptional repressor Bach-1, and induction of HO-1 when HO enzymatic activity was inhibited was related to worst outcome after brain ischemia.

  14. Bach1 deficiency ameliorates TNBS colitis.

  15. Our data provide evidence for a critical role of Bach1 in cell transformation and tumor growth induced by activated H-Ras(V12).

  16. apoptosis rate was significantly lower at 1 and 2 weeks post-puncture in Bach 1-/- mice

  17. Transcriptional network analysis identifies BACH1 as a master regulator of breast cancer bone metastasis

  18. Loss of Bach1 is associated with impaired APC development accompanied by defects in downstream T-cell responses and partial protection from experimental autoimmune encephalomyelitis.

  19. Bach1 regulates osteoclastogenesis under inflammatory conditions, via both HO-1-dependent and HO-1-independent mechanisms.

  20. The p19(ARF)-Bach1 interaction constitutes a regulatory pathway of p53 in parallel with the p19(ARF)-MDM2 pathway.

Human BTB and CNC Homology 1, Basic Leucine Zipper Transcription Factor 1 (BACH1) Interaktionspartner

  1. BACH1 is overexpressed in prostate cancer

  2. BACH1 may inhibit the progression of colorectal cancer through BACH1/CXCR4 pathway.

  3. BACH1 overexpression impaired the association between p53 and SP1 via competitive binding p53, and antagonized the impact of p53 on MGMT expression.

  4. In light of a pivotal role of NRF2 and BACH1 in response to oxidative stress and regulation of HO-1, we examined if smoke-induced HO-1 expression is modulated through the NRF2/BACH1 axis. We demonstrated that smoke causes significant nuclear translocation of NRF2, but only a slight decrease in nuclear BACH1.

  5. these findings suggested that increased miR-155 expression in activated monocytes leads to enhanced phagocytic activity via BACH-1 regulation in beta-thalassemia/HbE.

  6. The electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 signaling.

  7. Our results suggest that the bach1-specific small interfering RNA effectively decrease CXCR4 receptor, matrix metalloproteinase-9 expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR-145

  8. BACH1 down-regulation in HT29 colon cancer cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression.

  9. This study indicates that the expression of BACH1 could be elevated as a compensatory mechanism to decrease the globin chain imbalance as well as to reduce the oxidative stress found in hemoglobin E/beta-thalassemia.

  10. A short while ago some studies suggested that BACH1 is involved in cancers, especially breast cancer. This factor is mentioned as a novel master regulator which adjusts several genes involved in bone metastasis of breast cancer, especially CXCR4 and MMP1, two main genes in the enhancement of cancer cell migration and invasion to distant organs. [Review]

  11. Bach1 suppresses cell proliferation and induces cell-cycle arrest and apoptosis.

  12. Induction of GSH-related genes xCT and GCLM were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2-Keap1 defense pathway

  13. heme oxygenase-1 expression is induced by gold nanoparticles through Nrf2 activation and Bach1 export in human vascular endothelial cells

  14. Cyanidin-3-O-glucoside protects HUVECs from palmitic acid-induced injuryby modulating the balance of Nrf2 versus Bach1 inside the nucleus so influencing upregulation of electrophile responsive element mediated gene expression.

  15. sensitizer-induced up-regulation of both the endogenous HMOX1 and the luciferase constructs under the control of the HMOX1-ARE or the full HMOX1 promoter appear to be under the control of both Nrf2 and Bach1.

  16. This study demonstrated that Bach1 overexpression in Down syndrome correlates with the alteration of the HO-1/BVR-a system.

  17. Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt/beta-catenin signaling by disrupting the interaction between beta-catenin and TCF4 and by recruiting histone deacetylase 1 to the promoter of TCF4-targeted genes.

  18. Higher HMOX1 expression correlated with higher expression of Bach-1 (Spearman's rho = 0.586, p = 0.000001) and miR-122 (Spearman's rho = 0.270, p = 0.014059).

  19. The Bach1-dependent repression of the HO-1 expression is under the control of the Hx-dependent uptake of extracellular heme

  20. The arsenic-induced Nrf2 pathway activation in hepatocytes suggested that the translocation of Bach1 was associated with the regulation of Nrf2 pathway by arsenic.

BACH1 Protein Überblick

Protein Überblick

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.

Genbezeichner und Symbole assoziert mit BACH1

  • BTB domain and CNC homolog 1 (BACH1)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 1 b (bach1b)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 1 (bach1)
  • BTB and CNC homology 1, basic leucine zipper transcription factor 1 (Bach1)
  • BTB domain and CNC homolog 1 (Bach1)
  • 6230421P05Rik Protein
  • AI323795 Protein
  • BACH-1 Protein
  • BACH1 Protein
  • zgc:112205 Protein

Bezeichner auf Proteinebene für BACH1

BTB and CNC homology 1 transcription factor , BTB and CNC homology 1, basic leucine zipper transcription factor 1 , basic leucine zipper transcription factor 1 , transcription regulator protein BACH1-like , BTB and CNC homolog 1 , transcription regulator protein BACH1 , HA2303 , basic region leucine zipper transcriptional regulator BACH1

GENE ID SPEZIES
418488 Gallus gallus
487718 Canis lupus familiaris
531350 Bos taurus
100523514 Sus scrofa
553688 Danio rerio
705817 Macaca mulatta
745234 Pan troglodytes
100053654 Equus caballus
100125783 Xenopus (Silurana) tropicalis
100353797 Oryctolagus cuniculus
100385069 Callithrix jacchus
100448413 Pongo abelii
100464674 Ailuropoda melanoleuca
100549402 Meleagris gallopavo
100595281 Nomascus leucogenys
12013 Mus musculus
571 Homo sapiens
304127 Rattus norvegicus
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