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BACH1 encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip).
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Bach1 regulates the liver specificity and transience of the Nrf2a (zeige NFE2L2 Proteine)-dependent induction of hmox1a and that heme mediates this regulation through Bach1 inhibition based on its level in each tissue.
The Bach1b-MafK heterodimer represses the zymogen promoters, whereas the Nrf2a-MafK heterodimer activates them.
Theraputic effects of Pirfenidone for induced pulmonary fibrosis were involved in Nrf2 (zeige NFE2L2 Proteine)/Bach1 equilibrium which regulated the capacity of oxidative stress.
Data suggest that Abcb10 (zeige ABCB10 Proteine) silencing results in alteration in heme biosynthesis transcriptional profile due to repression by transcriptional regulator Bach1. (Abcb10 (zeige ABCB10 Proteine) = ATP-binding cassette, sub-family B [MDR-TAP], member 10; Bach1 = BTB and CNC homology 1, basic leucine zipper transcription factor 1)
This study showed that RANKL (zeige TNFSF11 Proteine) favors osteoclastogenesis via attenuation of Nrf2 (zeige NFE2L2 Proteine)-mediated antioxidant enzyme expression by competing with Bach1 nuclear accumulation.
this study provides new insight into the function of iron and Bach1 in erythroblast maturation by using efficacious regimens that can induce severe ID.
miR (zeige MLXIP Proteine)-196a, which binds to the 3'-untranslated region of the transcriptional repressor BTB and CNC homology 1 (Bach1) and regulates its expression, and subsequently leads to higher levels of lung HO-1 (zeige HMOX1 Proteine) mRNA.
Bach1 siRNA exerts protective effects against bleomycin-induced pulmonary fibrosis in mice.
These results suggest that Bach1 and Bach2 (zeige BACH2 Proteine) work in a complementary manner to maintain the normal function of the AMs (zeige MAT1A Proteine) and surfactant homeostasis in the lung.
By integrating the chromatin immunoprecipitation and next-generation sequencing data with a comparative analysis of gene expression in Bach1-deficient and wild type immortalized mouse embryonic fibroblasts (iMEFs), study found 35 new genes whose expression was repressed by BACH1. Known functions of some of these genes suggested a role of BACH1 in adipocyte differentiation, which was verified using iMEFs.
Bach1 deficiency reduces the severity of osteoarthritis-like changes. This may be due to maintenance of cartilage homeostasis and joint health by antioxidant effects
Bach1 suppresses angiogenesis after ischemic injury and impairs Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) signaling by disrupting the interaction between beta-catenin (zeige CTNNB1 Proteine) and TCF4 (zeige TCF4 Proteine) and by recruiting histone deacetylase 1 (zeige HDAC1 Proteine) to the promoter of TCF4 (zeige TCF4 Proteine)-targeted genes.
BACH1 overexpression impaired the association between p53 (zeige TP53 Proteine) and SP1 (zeige PSG1 Proteine) via competitive binding p53 (zeige TP53 Proteine), and antagonized the impact of p53 (zeige TP53 Proteine) on MGMT (zeige MGMT Proteine) expression.
In light of a pivotal role of NRF2 (zeige GABPA Proteine) and BACH1 in response to oxidative stress and regulation of HO-1 (zeige HMOX1 Proteine), we examined if smoke-induced HO-1 (zeige HMOX1 Proteine) expression is modulated through the NRF2 (zeige GABPA Proteine)/BACH1 axis. We demonstrated that smoke causes significant nuclear translocation of NRF2 (zeige GABPA Proteine), but only a slight decrease in nuclear BACH1.
these findings suggested that increased miR (zeige MLXIP Proteine)-155 expression in activated monocytes leads to enhanced phagocytic activity via BACH-1 regulation in beta-thalassemia/HbE (zeige HBe1 Proteine).
The electrophilic character of quinones ensure their conjugation with Bach1, which is important for the downregulation of Bach1 and the upregulation of Nrf2 (zeige GABPA Proteine) signaling.
Our results suggest that the bach1-specific small interfering RNA effectively decrease CXCR4 (zeige CXCR4 Proteine) receptor, matrix metalloproteinase-9 (zeige MMP9 Proteine) expression and breast adenocarcinoma cells invasive, also increased the expression of tumor-suppressive microRNA-203 and miR (zeige MLXIP Proteine)-145
BACH1 down-regulation in HT29 colon cancer cells had no effect on cell growth but did inhibit cell migration by decreasing metastasis-related genes expression.
This study indicates that the expression of BACH1 could be elevated as a compensatory mechanism to decrease the globin chain imbalance as well as to reduce the oxidative stress found in hemoglobin E/beta-thalassemia.
A short while ago some studies suggested that BACH1 is involved in cancers, especially breast cancer. This factor is mentioned as a novel master regulator which adjusts several genes involved in bone metastasis of breast cancer, especially CXCR4 (zeige CXCR4 Proteine) and MMP1 (zeige MMP1 Proteine), two main genes in the enhancement of cancer cell migration and invasion to distant organs. [Review]
Bach1 suppresses cell proliferation and induces cell-cycle arrest and apoptosis.
Induction of GSH-related genes xCT (zeige SLC7A11 Proteine) and GCLM (zeige GCLM Proteine) were oxygen and Bach1-insensitive during long-term culture under 5% O2, providing the first evidence that genes related to GSH synthesis mediate protection afforded by Nrf2 (zeige GABPA Proteine)-Keap1 (zeige KEAP1 Proteine) defense pathway
This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. When this encoded protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene.
BTB and CNC homology 1 transcription factor
, BTB and CNC homology 1, basic leucine zipper transcription factor 1
, basic leucine zipper transcription factor 1
, transcription regulator protein BACH1-like
, BTB and CNC homolog 1
, transcription regulator protein BACH1
, basic region leucine zipper transcriptional regulator BACH1