Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Zusätzlich bieten wir Ihnen BAP1 Proteine (7) und BAP1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 134 products:
Human Polyclonal BAP1 Primary Antibody für IHC (p), WB - ABIN388948
Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011
Human Monoclonal BAP1 Primary Antibody für FACS, WB - ABIN258775
Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010
Studies have clarified novel important molecular aspects associated with the cancer predisposition of BAP1 (zeige RNF2 Antikörper)+/- carrying individuals and suggest new relevant questions, related to BAP1 (zeige RNF2 Antikörper)-dependent cancer susceptibility, and to more general gene/environment interactions.
The authors demonstrate that BAP1 (zeige RNF2 Antikörper) deubiquitinase activity and its association with ASXL1 (zeige ASXL1 Antikörper) to form the Polycomb (zeige CBX2 Antikörper) repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism.
Case Report: germline BAP1 (zeige RNF2 Antikörper) mutation associated with melanoma of foot.
Tissue-specific prognostic and clinicopathological significance of BAP1 (zeige RNF2 Antikörper) expression (meta-analysis).
these results highlight an important role of miR (zeige MLXIP Antikörper)-31 functioning as an oncomir which could promote EMT (zeige ITK Antikörper) in cervical cancer via downregulating BAP1 (zeige RNF2 Antikörper) expression. Thus, downregulation of miR (zeige MLXIP Antikörper)-31 could be a novel approach for the molecular treatment of cervical cancers and other malignancies.
A cancer surveillance program for individuals who carry germline BAP1 (zeige RNF2 Antikörper) mutations may help identify tumors such as uveal melanoma, cutaneous melanoma, and renal cell carcinoma (zeige MOK Antikörper) at early and treatable stages
Germline BAP1 (zeige RNF2 Antikörper) mutations induce a Warburg effect
Our comparative thermodynamic analysis reveals that BAP1-ubiquitin interaction is majorly driven by entropy factor which is unique amongst UCHs. Our study sheds light on BAP1 interaction with ubiquitin, which will be useful in understanding its enzymatic function.
Mutations in BAP1 (zeige RNF2 Antikörper) negatively affected overall survival in patients with metastatic clear cell renal cell carcinoma (zeige MOK Antikörper)
Our findings suggest that the genetic profile of coexistent GNAQ (zeige GNAQ Antikörper) or GNA11 (zeige GNA11 Antikörper) mutations with BAP1 (zeige RNF2 Antikörper) or SF3B1 (zeige SF3B2 Antikörper) mutations can aid the histopathological diagnosis of blue nevus-like melanoma and distinguish blue nevus-like melanoma from conventional epidermal-derived melanomas.
We conditionally targeted Bap1 and Pbrm1 (zeige PBRM1 Antikörper) (with Vhl (zeige VHL Antikörper)) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC)origins
our results establish a previously unappreciated role of BAP1 in modulating the cellular adaptability to metabolic stress and uncover a pivotal function of BAP1 in the regulation of the ER stress gene-regulatory network.
dual inactivation of Vhl (zeige VHL Antikörper) with either Bap1 or Pbrm1 (zeige PBRM1 Antikörper) results in faithful genetically engineered murine models of clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC).
Bap1 as a metabolic regulator in liver and pancreas.
BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.
Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.
INO80 (zeige INO80 Antikörper) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells
Both Vhl (zeige VHL Antikörper) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (zeige VHL Antikörper) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (zeige VHL Antikörper) in the kidney.
Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.
results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (zeige HCFC1 Antikörper) and OGT (zeige OGT Antikörper) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm
The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.
cerebral protein 6
, cerebral protein-13
, ubiquitin carboxyl-terminal hydrolase BAP1
, BAI1-associated protein 3
, BRCA1-associated protein 1
, ubiquitin carboxy-terminal hydrolase
, Brca1 associated protein 1
, ubiquitin C-terminal hydrolase X4
, BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)