anti-BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) Antikörper

The protein encoded by BAP1 localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). Zusätzlich bieten wir Ihnen BAP1 Proteine (7) und BAP1 Kits (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BAP1 8314 Q92560
BAP1 306257 D3ZHS6
BAP1 104416 Q99PU7
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Top anti-BAP1 Antikörper auf antikoerper-online.de

Showing 10 out of 134 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of BAP1 Antibody (N-term) (ABIN388948) in mouse testis lysates (35 µg/lane). BAP1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Kaninchen Unkonjugiert WB The anti-BAP1 Pab (ABIN388949) is used in Western blot to detect BAP1 in SK-BR-3 cell lysate. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$335.50
Details
Human Maus Unkonjugiert WB Anti-BAP1 antibody (monoclonal), Western blotting Lane: MCF-7 Cell Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Maus Unkonjugiert FACS, WB Detection of BAP1 in HeLa WCE using ABIN258775 (2ug/ml). Flow Cytometry: BAP1 Antibody (1G8) [ABIN2587751] - Intracellular flow cytometric staining of 1 x 10^6 CHO (A) and HEK-293 (B) cells using BAP1 antibody (dark blue). Isotype control shown in orange. An antibody concentration of 1 ug/1x10^6 cells was used. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$444.19
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert ICC, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$449.17
Details
Human Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of BAP1 staining in Hela cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of BAP1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Maus Unkonjugiert IF, WB 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$379.50
Details
Human Kaninchen Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details

Am meisten referenzierte anti-BAP1 Antikörper

  1. Human Polyclonal BAP1 Primary Antibody für IHC (p), WB - ABIN388948 : Abdel-Rahman, Pilarski, Cebulla, Massengill, Christopher, Boru, Hovland, Davidorf: Germline BAP1 mutation predisposes to uveal melanoma, lung adenocarcinoma, meningioma, and other cancers. in Journal of medical genetics 2011 (PubMed)

  2. Human Monoclonal BAP1 Primary Antibody für FACS, WB - ABIN258775 : Harbour, Onken, Roberson, Duan, Cao, Worley, Council, Matatall, Helms, Bowcock: Frequent mutation of BAP1 in metastasizing uveal melanomas. in Science (New York, N.Y.) 2010 (PubMed)

Weitere Antikörper gegen BAP1 Interaktionspartner

Human BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) Interaktionspartner

  1. Studies have clarified novel important molecular aspects associated with the cancer predisposition of BAP1 (zeige RNF2 Antikörper)+/- carrying individuals and suggest new relevant questions, related to BAP1 (zeige RNF2 Antikörper)-dependent cancer susceptibility, and to more general gene/environment interactions.

  2. The authors demonstrate that BAP1 (zeige RNF2 Antikörper) deubiquitinase activity and its association with ASXL1 (zeige ASXL1 Antikörper) to form the Polycomb (zeige CBX2 Antikörper) repressive deubiquitinase complex (PR-DUB) impacts TRAIL sensitivity implicating transcriptional modulation as an underlying mechanism.

  3. Case Report: germline BAP1 (zeige RNF2 Antikörper) mutation associated with melanoma of foot.

  4. Tissue-specific prognostic and clinicopathological significance of BAP1 (zeige RNF2 Antikörper) expression (meta-analysis).

  5. these results highlight an important role of miR (zeige MLXIP Antikörper)-31 functioning as an oncomir which could promote EMT (zeige ITK Antikörper) in cervical cancer via downregulating BAP1 (zeige RNF2 Antikörper) expression. Thus, downregulation of miR (zeige MLXIP Antikörper)-31 could be a novel approach for the molecular treatment of cervical cancers and other malignancies.

  6. A cancer surveillance program for individuals who carry germline BAP1 (zeige RNF2 Antikörper) mutations may help identify tumors such as uveal melanoma, cutaneous melanoma, and renal cell carcinoma (zeige MOK Antikörper) at early and treatable stages

  7. Germline BAP1 (zeige RNF2 Antikörper) mutations induce a Warburg effect

  8. Our comparative thermodynamic analysis reveals that BAP1-ubiquitin interaction is majorly driven by entropy factor which is unique amongst UCHs. Our study sheds light on BAP1 interaction with ubiquitin, which will be useful in understanding its enzymatic function.

  9. Mutations in BAP1 (zeige RNF2 Antikörper) negatively affected overall survival in patients with metastatic clear cell renal cell carcinoma (zeige MOK Antikörper)

  10. Our findings suggest that the genetic profile of coexistent GNAQ (zeige GNAQ Antikörper) or GNA11 (zeige GNA11 Antikörper) mutations with BAP1 (zeige RNF2 Antikörper) or SF3B1 (zeige SF3B2 Antikörper) mutations can aid the histopathological diagnosis of blue nevus-like melanoma and distinguish blue nevus-like melanoma from conventional epidermal-derived melanomas.

Mouse (Murine) BRCA1 Associated Protein-1 (Ubiquitin Carboxy-terminal Hydrolase) (BAP1) Interaktionspartner

  1. We conditionally targeted Bap1 and Pbrm1 (zeige PBRM1 Antikörper) (with Vhl (zeige VHL Antikörper)) in the mouse using several Cre drivers.Sglt2 and Villin proximal convoluted tubule drivers failed to cause tumorigenesis, challenging the conventional notion of Clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC)origins

  2. our results establish a previously unappreciated role of BAP1 in modulating the cellular adaptability to metabolic stress and uncover a pivotal function of BAP1 in the regulation of the ER stress gene-regulatory network.

  3. dual inactivation of Vhl (zeige VHL Antikörper) with either Bap1 or Pbrm1 (zeige PBRM1 Antikörper) results in faithful genetically engineered murine models of clear cell renal cell carcinoma (zeige MOK Antikörper) (ccRCC).

  4. Bap1 as a metabolic regulator in liver and pancreas.

  5. BAP1(+/-) mice exposed to low-dose asbestos fibers showed an altered peritoneal inflammatory response and higher levels of pro-tumorigenic alternatively polarized M2 macrophages, and lower cytokine levels. They had a higher incidence of mesothelioma.

  6. Bap1 loss led to a fully penetrant myeloproliferative disease with splenomegaly, leukocytosis, anemia and progenitor expansion via alterations in histone methylation and gene expression.

  7. INO80 (zeige INO80 Antikörper) is stabilized and targeted to replication forks by BAP1 during normal DNA synthesis but downregulated in BAP1 defective cancer cells

  8. Both Vhl (zeige VHL Antikörper) and Bap1 are required for kidney function. Inactivation of Bap1 in neprhon progenitor cells causes renal failure earlier than Vhl (zeige VHL Antikörper) inactivation. Bap1 is also a stronger tumor suppressor gene than Vhl (zeige VHL Antikörper) in the kidney.

  9. Drawing parallels to human disease, these unbiased genetic findings indicate that BAP1 mutation carriers are predisposed to the tumorigenic effects of asbestos and suggest that high penetrance of mesothelioma requires such environmental exposure.

  10. results identify a potent tumor suppressor function for BAP1 in myeloid neoplasia; propose that BAP1 forms a core complex with HCF-1 (zeige HCFC1 Antikörper) and OGT (zeige OGT Antikörper) that can differentially recruit additional histone-modifying enzymes to regulate gene expression and preserve norm

BAP1 Antigen-Profil

Protein Überblick

The protein encoded by this gene localizes to the nucleus and it interacts with the RING finger domain of the breast cancer 1, early onset protein (BRCA1). This gene is thought to be a tumor suppressor gene that functions in the BRCA1 growth control pathway. There are multiple polyadenylation sites found in this gene.

Genbezeichner und Symbole assoziert mit BAP1

  • BRCA1 associated protein 1 (BAP1) Antikörper
  • Brca1 associated protein 1 (Bap1) Antikörper
  • BRCA1 associated protein 1 L homeolog (bap1.L) Antikörper
  • BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase) (bap1) Antikörper
  • BRCA1 associated protein 1 (Bap1) Antikörper
  • 2300006C11Rik Antikörper
  • AA989761 Antikörper
  • AW553466 Antikörper
  • BAIAP3 Antikörper
  • hucep-6 Antikörper
  • hucep-13 Antikörper
  • mKIAA0272 Antikörper
  • si:dkey-42i9.9 Antikörper
  • uch-x4 Antikörper
  • uchl2 Antikörper

Bezeichner auf Proteinebene für BAP1

cerebral protein 6 , cerebral protein-13 , ubiquitin carboxyl-terminal hydrolase BAP1 , BAI1-associated protein 3 , BRCA1-associated protein 1 , ubiquitin carboxy-terminal hydrolase , Brca1 associated protein 1 , ubiquitin C-terminal hydrolase X4 , BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)

GENE ID SPEZIES
8314 Homo sapiens
100124510 Bos taurus
306257 Rattus norvegicus
484737 Canis lupus familiaris
104416 Mus musculus
415944 Gallus gallus
734438 Xenopus laevis
558885 Danio rerio
100731081 Cavia porcellus
100051934 Equus caballus
100154798 Sus scrofa
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