ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 Proteine (ARAP1)

The protein encoded by ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. Zusätzlich bieten wir Ihnen ARAP1 Antikörper (51) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ARAP1 69710 Q4LDD4
ARAP1 116985 Q96P48
Ratte ARAP1 ARAP1 361617  
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Showing 3 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg 70 Days
$13,741.67
Details
Wheat germ Human GST tag 10 μg 11 bis 12 Tage
$414.29
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ARAP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,
,

Weitere Proteine zu ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1) Interaktionspartnern

Mouse (Murine) ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1) Interaktionspartner

  1. competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process.

  2. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression.

  3. Increased ARAP1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.

  4. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.

  5. afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1.

Human ArfGAP with RhoGAP Domain, Ankyrin Repeat and PH Domain 1 (ARAP1) Interaktionspartner

  1. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression.

  2. Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population.

  3. The proinsulin-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets.

  4. a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1/5 pathway.

  5. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.

  6. Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin release.

  7. ARAP1 associated with CIN85 affects epidermal growth factor receptor endocytic trafficking

  8. PTK6 enhances EGFR signaling by inhibition of EGFR down-regulation through phosphorylation of ARAP1 in breast cancer cells.

  9. ARAP1 acts primarily on Arf6 in vivo.

  10. ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death.

  11. ARAP1 controls the late steps of the endocytic trafficking of the EGF-R

  12. ARAP1 regulates the endocytic traffic of EGFR and, consequently, the rate of EGFR signal attenuation

  13. Data suggest that ARAP1 is recruited to membranes independently of PtdIns(3,4,5)P(3), the subsequent production of which triggers enzymatic activity.

ARAP1 Protein Überblick

Protein Überblick

The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit ARAP1

  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (ARAP1)
  • centaurin, delta 2 (centd2)
  • ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 (Arap1)
  • 2410002L19Rik Protein
  • ARAP1 Protein
  • Centd2 Protein
  • Ci-ArfGAP-8 Protein
  • mKIAA0782 Protein

Bezeichner auf Proteinebene für ARAP1

centaurin delta 2 , centaurin, delta 2 , ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1 , arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 , centaurin-delta-2 , cnt-d2 , ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1

GENE ID SPEZIES
451406 Pan troglodytes
511889 Bos taurus
100014939 Monodelphis domestica
100052506 Equus caballus
100090045 Ornithorhynchus anatinus
100341403 Oryctolagus cuniculus
100511767 Sus scrofa
100594751 Nomascus leucogenys
100169677 Ciona intestinalis
485207 Canis lupus familiaris
69710 Mus musculus
116985 Homo sapiens
361617 Rattus norvegicus
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