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The protein encoded by ARAP1 contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. Zusätzlich bieten wir Ihnen ARAP1 Antikörper (45) und viele weitere Produktgruppen zu diesem Protein an.
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Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 (zeige STARD10 Proteine) locus and STARD10 (zeige STARD10 Proteine) but not ARAP1 expression.
Increased ARAP (zeige INS Proteine)1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus.
Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II.
afadin regulates the cyclical activation and inactivation of Rap1 (zeige TERF2IP Proteine), Rac1, and RhoA (zeige RHOA Proteine) through SPA-1 and ARAP1.
Genetic variant rs1552224 of CENTD2 on chromosome 11 contributes to an independent effect as well as joint cumulative effect with rs2237897 of KCNQ1 on the risk of type 2 diabetes mellitus in Chinese Han population.
The proinsulin (zeige INS Proteine)-decreasing and T2D-risk Alleles are associated with increased ARAP1 mRNA levels in primary human pancreatic islets.
a novel molecular mechanism of circular dorsal ruffles ring size control through the ARAP1-Arf1 (zeige ARF1 Proteine)/5 pathway.
Of the lead variants from 12 novel type 2 diabetes associated loci, CENTD2 significantly associated with increased plasma glucose values and decreased glucose-stimulated insulin (zeige INS Proteine) release.
ARAP1 associated with CIN85 (zeige SH3KBP1 Proteine) affects epidermal growth factor receptor (zeige EGFR Proteine) endocytic trafficking
PTK6 (zeige PTK6 Proteine) enhances EGFR (zeige EGFR Proteine) signaling by inhibition of EGFR (zeige EGFR Proteine) down-regulation through phosphorylation of ARAP1 in breast cancer cells.
ARAP1 acts primarily on Arf6 (zeige ARF6 Proteine) in vivo.
ARAP1 knockdown significantly compromises the localization of death receptor 4 at the cell surface of several tumor cell lines and slows down their TRAIL-induced death.
The protein encoded by this gene contains SAM, ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology (PH) domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. It is thought to regulate the cell-specific trafficking of a receptor protein involved in apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.
centaurin delta 2
, centaurin, delta 2
, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1
, arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1
, ARF-GAP, RHO-GAP, ankyrin repeat, and pleckstrin homology domains-containing protein 1