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ANGPTL3 encodes a member of a family of secreted proteins that function in angiogenesis.
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Mouse (Murine) ANGPTL3 ELISA Kit für Sandwich ELISA - ABIN425029
Méndez-González, Julve, Rotllan, Llaverias, Blanco-Vaca, Escolà-Gil: ATP-binding cassette G5/G8 deficiency causes hypertriglyceridemia by affecting multiple metabolic pathways. in Biochimica et biophysica acta 2011
Human ANGPTL3 ELISA Kit für Sandwich ELISA - ABIN4881825
Bassyouni, Sharaf, Wali, Mansour: Clinical significance of Angiopoietin-1 in Behcet's disease patients with vascular involvement. in Heart and vessels 2017
Knockdown of Angptl3 decreases liver size in developing zebrafish.
circulating ANGPTL3 and ANGPTL 4 (zeige ANGPTL4 ELISA Kits) expression was significantly elevated in hepatocellular carcinoma cases compared to chronic hepatitis patients and controls
ANGPTL8 has a functional LPL (zeige LCP1 ELISA Kits) inhibitory motif, but only inhibits LPL (zeige LCP1 ELISA Kits) and increases plasma TG levels in mice in the presence of ANGPTL3
Our findings demonstrate that complete ANGPTL3 deficiency associates with highly reduced postprandial lipemia probably due to faster catabolism of intestinally derived lipoproteins, larger expansion of the postprandial FFA pool, and decreased influx of dietary-derived fatty acids into the liver. These results add information on mechanisms underlying hypolipidemia in familial combined hypolipidemia (FHBL2).
participants with heterozygous loss-of-function variants in ANGPTL3 had significantly lower serum levels of triglycerides, HDL (zeige HSD11B1 ELISA Kits) cholesterol, and LDL cholesterol than participants without these variants.
ANGPTL3 deficiency is associated with protection from coronary artery disease.
our data shows that ANGPTL3, 4 and 8 are increased in obesity and type 2 diabetes (T2D). ANGPTL8 associates with ANGPTL3 in the non-diabetic subjects while it associated more with ANGPTL4 (zeige ANGPTL4 ELISA Kits) in the obese and T2D subjects.
ANGPTL3 is specifically correlated with HDL (zeige HSD11B1 ELISA Kits)-c, apoA-I (zeige APOA1 ELISA Kits), SAA (zeige SAA1 ELISA Kits) and HDL (zeige HSD11B1 ELISA Kits) function in female non-diabetic participants. The decrease of ANGPTL3 level in female T2DM patients might contribute to its weak association to HDL (zeige HSD11B1 ELISA Kits) components and function.
The ANGPTL3 gene lies within DOCK7, although the variant is within non-coding regions outside of ANGPTL3, within DOCK7, suggesting complex long-range regulatory effects on gene expression in coronary artery disease.
ANGPTL3 levels were associated with fasting insulin (zeige INS ELISA Kits) and the homeostasis model assessment of insulin (zeige INS ELISA Kits) resistance in Korean children.
An ANGPTL3-4-8 model was proposed to explain the variations of lipoprotein lipase (LPL (zeige LPL ELISA Kits)) activity during the fed-fast cycle. Feeding induces ANGPTL8, activating the ANGPTL8-ANGPTL3 pathway, which inhibits LPL (zeige LCP1 ELISA Kits) in cardiac and skeletal muscles to direct circulating triglycerides (TG) to white adipose tissue; the reverse is true during fasting, which suppresses ANGPTL8 but induces ANGPTL4 (zeige ANGPTL4 ELISA Kits), thereby directing TG to muscles.
ANGPTL8 has a functional LPL (zeige LPL ELISA Kits) inhibitory motif, but only inhibits LPL (zeige LPL ELISA Kits) and increases plasma TG levels in mice in the presence of ANGPTL3
The data suggests that ANGPTL3 is part of the machinery causing dyslipidemia majorily via LPL (zeige LPL ELISA Kits) inhibition in mastitis mice.
Using in vitro ketosis model by glucose starvation, studied inhibition of ketosis by momilactone B. Found momilactone B could regulate the angiopoietin-like-3 (ANGPTL3)-lipoprotein lipase (LPL (zeige LPL ELISA Kits))pathway, and suppressed the expression of HMGCS2 (zeige HMGCS2 ELISA Kits) through the increased expression of STAT5b (zeige STAT5B ELISA Kits).
This model suggests a general mechanism by which TAG trafficking is coordinated by lipasin, Angptl3 and Angptl4 (zeige ANGPTL4 ELISA Kits) at different nutritional statuses.
Inactivation of ANGPTL3 reduces hepatic VLDL-triglyceride secretion
The deletion of ANGPTL3 tremendously attenuates proteinuria and protects podocytes from injury in a mouse model of adriamycin-induced nephropathy.
ANGPTL3 has a role in regulating white adipose tissue energy homeostasis but not in liver
Data indicate that expression of Angptl3 in hematopoietic stem cell (HSC) through lentiviral transduction promoted HSC expansion.
Angptl3 could induce actin filament rearrangement, mainly in lamellipodia formation, and that this process was mediated by integrin alpha(V)beta-mediated FAK and PI3K phosphorylation and Rac1 activation.
Furin (zeige FURIN ELISA Kits) has a role as the primary in vivo convertase of ANGPTL3 and endothelial lipase (zeige LIPG ELISA Kits) in hepatocytes
First report of molecular cloning and characterization of ANGPTL3 in pigs, which will be helpful for a better understanding of the role of ANGPTLs in lipid metabolism.
This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metablism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2.
, WITHDRAWN: zgc:111943
, angiopoietin-related protein 3-like
, angiopoietin 5
, angiopoietin-related protein 3
, angiopoietin-like protein 3