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ACVR2A encodes activin A type II receptor. Zusätzlich bieten wir Ihnen Activin Receptor Type IIA Antikörper (113) und Activin Receptor Type IIA Kits (15) und viele weitere Produktgruppen zu diesem Protein an.
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TGF-beta (zeige TGFB1 Proteine) receptor mediated telomerase inhibition, telomere shortening and breast cancer cell senescence.(
This locus harbors an evolutionary conserved gene-desert region with non-coding intergenic sequences likely involved in regulation of protein-coding flanking genes ZEB2 and ACVR2A. This region is intensively studied for mutations causing severe developmental/genetic disorders. Our analyses indicate a promising target region for interventions aimed to reduce risks of many major human diseases and mortality.
Data suggest ALK1 (zeige ACVRL1 Proteine) and ACVR2A/ACVR2B (zeige ACVR2B Proteine), acting as BMP9 (zeige GDF2 Proteine) co-receptors, rearrange pro-domains of BMP9 (zeige GDF2 Proteine)--pro-domain dimer complex leading to displacement of pro-domains after receptor binding, release of mature non-dimer BPM9, and activation of signaling.
Activin A (zeige INHBA Proteine) inhibited signaling by BMP-6 (zeige BMP6 Proteine) and BMP-9 (zeige GDF2 Proteine) by competing for type 2 receptors ACVR2A and ACVR2B (zeige ACVR2B Proteine).
Data suggest that an SNP in promoter region of ACVR2A (rs1424954, the pre-eclampsia susceptibility allele) down-regulates 1) expression of ACVR2A in trophoblasts and 2) signal transduction in response to excess activin-A (zeige INHBA Proteine) (as seen in pre-eclampsia).
Adenomyotic tissues express high levels of myostatin, follistatin, and activin type II receptors.
The gene ACVR2A was associated with the more severe early onset preeclampsia.
For ACVR2A SNPs (rs10497025, rs1128919, rs13430086), no statistically significant difference was found between preeclampsia and control groups in terms of genotype and allele frequencies.
ACVR2A was identified as a subnetwork component in functional association network analysis.
ACVR2A showed statistically significant differential dose-expression relationship.
This genome-wide association study identified variants in the upstream region of ACVR2A, which were associated with female fertility in Japanese Black cattle.
Roles in hindbrain and neural crest cell (NCC) patterning, in NCC derived pharyngeal arch cartilage and joint formation, and in tooth development.
Anti-ActRII blockade is an effective intervention against cancer cachexia providing benefit even in the presence of anti-cancer therapies.
Data, including data from studies using transgenic mice, suggest that osteoblasts deficient in Acvr2A exhibit un-characteristic features; osteoclasts deficient in Acvr2A or Acvr2B (zeige ACVR2B Proteine) or both appear normal. Acvr2A-deficient mice exhibit significantly increased femoral trabecular bone volume at 6 weeks of age; Acvr2B (zeige ACVR2B Proteine)-deficient mice exhibit no significant change in any bone parameter.
miR (zeige MLXIP Proteine)-125b regulated the activin/Smad2 (zeige SMAD2 Proteine) signaling in neonatal mouse ovary by directly targeting the 3'-untranslated region of activin receptor type 2a
Our study shows that a miR (zeige MLXIP Proteine)-590/Acvr2a/Rad51b (zeige Rad51B Proteine) signaling axis ensures the stabilization of mESCs by balancing DNA damage repair and rapid proliferation during self-renewal.
Bmpr2 (zeige BMPR2 Proteine) and Acvr2a normally play cell-type-specific, necessary roles in organelle biogenesis and the shutdown of developmental programs and cell division.
Acvr2a is a Th17 specific gene making Th17 cells distinct from other helper T cells, Th1 (zeige HAND1 Proteine), Th2, and Treg.
stimulates expression of APRIL via the Smad3 (zeige SMAD3 Proteine) and ERK (zeige EPHB2 Proteine)/CREB (zeige CREB1 Proteine) pathways in macrophages
Results demonstrated that BMPRII (zeige BMPR2 Proteine) and ActRII are the functional type II TGF-beta (zeige TGFB1 Proteine) receptors in BMP-9 (zeige GDF2 Proteine)-induced osteogenic differentiation of C3H10T1/2 cells.
The coordinated activity of ActRIIA and BMPRII (zeige BMPR2 Proteine) receptor subunits selectively mediates the chemotactic response to BMP7 (zeige BMP7 Proteine).
Activin type IIB(ActRIIB (zeige ACVR2B Proteine)) and its subfamily receptor, Activin type IIA (ActRIIA), cooperatively mediate the Gdf11 (zeige GDF11 Proteine) signal in patterning the axial vertebrae
This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.
activin receptor IIA
, activin receptor type-2A
, activin A receptor, type IIA
, activin receptor type IIA
, type II activin receptor
, activin A receptor, type II
, activin receptor, type IIA
, activin receptor type II
, activin type 2 receptor
, activin receptor IIa