ATPase Family, AAA Domain Containing 3A Proteine (ATAD3A)

ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008].. Zusätzlich bieten wir Ihnen ATAD3A Antikörper (52) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ATAD3A 55210 Q9NVI7
ATAD3A 108888 Q925I1
Ratte ATAD3A ATAD3A 298682 Q3KRE0
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,355.45
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Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,465.26
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,626.01
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ATAD3A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,

Weitere Proteine zu ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartnern

Human ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartner

  1. ATAD3A region deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

  2. identification of a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing in five unrelated individuals with a core phenotype of global developmental delay, hypotonia, optic atrophy, axonal neuropathy, and hypertrophic cardiomyopathy

  3. Mutations in ATAD3A can thus be dominantly inherited and underlie variable neurological phenotypes, including hereditary spastic paraplegia with intrafamiliar variability. This finding extends the group of mitochondrial inner membrane AAA (zeige APP Proteine) proteins associated with spasticity.

  4. stabilization of WASF3 (zeige WASF3 Proteine) function occurs through its interaction with ATAD3A and GRP78 (zeige HSPA5 Proteine), which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles

  5. These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria.

  6. High ATAD3A expression correlates with radioresistance in glioblastoma.

  7. exploring ATAD3 mRNA expression, we confirmed the existence of an alternative splicing in rodent and of several mRNA isoforms in human

  8. ATAD3B (zeige ATAD3B Proteine) is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in human pluripotent embryonic stem cells and cancer cells.

  9. Engineered a high copy strain expressing human ATAD3A-Myc (zeige MYC Proteine)-HIS at a relative high level (2.5mg/l of yeast culture)without significantly affecting yeast growth.Urea-denaturated ATAD3A-Myc (zeige MYC Proteine)-HIS bound to agarose-nickel beads and could be renatured and eluted.

  10. ATAD3 may be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular organization and involved in tumorigenesis.

Mouse (Murine) ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartner

  1. Loss of Atad3a caused accumulation of Pink1 (zeige PINK1 Proteine) and activated mitophagy.

  2. These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria.

  3. exploring ATAD3 mRNA expression, we confirmed the existence of an alternative splicing in rodent and of several mRNA isoforms in human

  4. ATAD3 is present in five native mitochondrial protein (zeige COX6B2 Proteine) complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function.

Cow (Bovine) ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartner

  1. ATAD3A positively regulated milk protein (zeige CSN2 Proteine), fat, and lactose biosynthesis, and cell proliferation by mammary epithelial cells.

ATAD3A Protein Überblick

Protein Überblick

ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007

Genbezeichner und Symbole assoziert mit ATAD3A

  • ATPase family, AAA domain containing 3A (ATAD3A)
  • ATPase family, AAA domain containing 3A (Atad3a)
  • 2400004H09Rik Protein
  • ATAD3 Protein
  • ATAD3B Protein
  • mKIAA1273 Protein
  • Tob3 Protein

Bezeichner auf Proteinebene für ATAD3A

ATPase family, AAA domain containing 3A , ATPase family AAA domain-containing protein 3A , AAA-ATPase TOB3 , ATPase family AAA domain-containing protein 3 , ATPase family, AAA domain containing 3 , ATPase family, AAA domain containing 3B

GENE ID SPEZIES
100222621 Taeniopygia guttata
55210 Homo sapiens
108888 Mus musculus
298682 Rattus norvegicus
784353 Bos taurus
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