ATPase Family, AAA Domain Containing 3A Proteine (ATAD3A)

ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007 [PubMed 17210950]).[supplied by OMIM, Sep 2008].. Zusätzlich bieten wir Ihnen ATAD3A Antikörper (50) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ATAD3A 55210 Q9NVI7
ATAD3A 108888 Q925I1
Ratte ATAD3A ATAD3A 298682 Q3KRE0
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$5,262.31
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Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$5,370.21
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$7,493.38
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ATAD3A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine) ,
,

Weitere Proteine zu ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartnern

Human ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartner

  1. ATAD3A region deletions cause cerebellar dysfunction associated with altered mitochondrial DNA and cholesterol metabolism.

  2. identification of a recurrent de novo ATAD3A c.1582C>T (p.Arg528Trp) variant by whole-exome sequencing in five unrelated individuals with a core phenotype of global developmental delay, hypotonia, optic atrophy, axonal neuropathy, and hypertrophic cardiomyopathy

  3. Mutations in ATAD3A can thus be dominantly inherited and underlie variable neurological phenotypes, including hereditary spastic paraplegia with intrafamiliar variability. This finding extends the group of mitochondrial inner membrane AAA proteins associated with spasticity.

  4. stabilization of WASF3 function occurs through its interaction with ATAD3A and GRP78, which may provide a bridge between the ER and mitochondria, allowing communication between the two organelles

  5. These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria.

  6. High ATAD3A expression correlates with radioresistance in glioblastoma.

  7. exploring ATAD3 mRNA expression, we confirmed the existence of an alternative splicing in rodent and of several mRNA isoforms in human

  8. ATAD3B is a negative regulator of ATAD3A and may function as an adaptor of mitochondrial homeostasis and metabolism in human pluripotent embryonic stem cells and cancer cells.

  9. Engineered a high copy strain expressing human ATAD3A-Myc-HIS at a relative high level (2.5mg/l of yeast culture)without significantly affecting yeast growth.Urea-denaturated ATAD3A-Myc-HIS bound to agarose-nickel beads and could be renatured and eluted.

  10. ATAD3 may be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular organization and involved in tumorigenesis.

  11. Results show that HPV infection correlates with increased ATAD3A expression and drug resistance in uterine cervical cancer.

  12. ATAD3 may therefore be implicated in an unknown but essential and growth-linked mitochondrial function existing since pluri-cellular -organization and involved in tumorigenesis.

  13. silencing of ATAD3A expression reduced PSA secretion and cisplatin resistance, suggesting that ATAD3A was associated with PSA secretion and drug resistance in PCa.

  14. gene expression in lung adenocarcinoma correlates with drug resistance and poor prognosis

  15. The N-terminal part of ATAD3A is outside the inner mitochondrial membrane and that the C-terminal part is inside the matrix.

  16. Data show that ATAD3A is a calcium-dependent S100B target protein in oligodendrocyte progenitor cells and suggest that S100B could assist the newly synthesized ATAD3A protein in proper folding and subcellular localization.

  17. Data show that the mitochondrial AAA(+) ATPase protein ATAD3A is involved in dynamic interactions between components of the outer and inner mitochondrial membranes which control a number of critical mitochondrial functions.

  18. Results suggest that mitochondrial DNA displacement loops serve to recruit ATAD3 protein for the purpose of forming or segregating mitochondrial nucleoids.

  19. We also have shown that the loss of ATAD 3A/3B may be involved in the transformation pathway and the chemosensitivity of oligodendrogliomas.

Mouse (Murine) ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartner

  1. Fancd2 localizes in the mitochondrion and associates with the nucleoid complex components Atad3 and Tufm.

  2. Loss of Atad3a caused accumulation of Pink1 and activated mitophagy.

  3. These results demonstrate that ATAD3-mediated mitochondrial membrane formation participates in the optimal transfer of cholesterol from the endoplasmic reticulum into mitochondria.

  4. exploring ATAD3 mRNA expression, we confirmed the existence of an alternative splicing in rodent and of several mRNA isoforms in human

  5. ATAD3 is present in five native mitochondrial protein complexes of different sizes, indicating complex roles of the protein in mitochondrial architecture and function.

Cow (Bovine) ATPase Family, AAA Domain Containing 3A (ATAD3A) Interaktionspartner

  1. ATAD3A positively regulated milk protein, fat, and lactose biosynthesis, and cell proliferation by mammary epithelial cells.

ATAD3A Protein Überblick

Protein Überblick

ATAD3A and ATAD3B (MIM 612317) are mitochondrial membrane proteins that contribute to the stabilization of large mitochondrial DNA (mtDNA)-protein complexes called nucleoids (He et al., 2007

Genbezeichner und Symbole assoziert mit ATAD3A

  • ATPase family, AAA domain containing 3A (ATAD3A)
  • ATPase family, AAA domain containing 3A (Atad3a)
  • 2400004H09Rik Protein
  • ATAD3 Protein
  • ATAD3B Protein
  • mKIAA1273 Protein
  • Tob3 Protein

Bezeichner auf Proteinebene für ATAD3A

ATPase family, AAA domain containing 3A , ATPase family AAA domain-containing protein 3A , AAA-ATPase TOB3 , ATPase family AAA domain-containing protein 3 , ATPase family, AAA domain containing 3 , ATPase family, AAA domain containing 3B

GENE ID SPEZIES
100222621 Taeniopygia guttata
55210 Homo sapiens
108888 Mus musculus
298682 Rattus norvegicus
784353 Bos taurus
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