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ASF1A encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. Zusätzlich bieten wir Ihnen ASF1A Proteine (12) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ASF1A Primary Antibody für ELISA, WB - ABIN4281853 : Sanematsu, Takami, Barman, Fukagawa, Ono, Shibahara, Nakayama: Asf1 is required for viability and chromatin assembly during DNA replication in vertebrate cells. in The Journal of biological chemistry 2006 (PubMed)
ASF1A is aberrantly over-expressed in GIC tumors and plays key roles in GIC development and progression by stimulating the transcription of beta-catenin (zeige CTNNB1 Antikörper) target genes.
ASF1a promotes non-homologous end joining repair by facilitating phosphorylation of MDC1 (zeige MDC1 Antikörper) by ATM (zeige ATM Antikörper) at double-strand breaks.
These data suggest that CAF-1 (zeige CHAF1B Antikörper)- and ASF1A-H3-H4-dependent deposition of the histone (H3 (zeige HIST3H3 Antikörper)-H4)2 tetramers is compatible with MMR (zeige MRC1 Antikörper) and protects the discontinuous daughter strand from unnecessary degradation by MMR (zeige MRC1 Antikörper) machinery.
Data show that the ubiquitin-conjugating enzyme E2 RAD6A/B-MDM2 ubiquitin ligase machinery regulates anti-silencing function 1A protein (ASF1A) degradation.
quaternary complex of histone H3 (zeige HIST3H3 Antikörper)-H4 heterodimer with chaperone ASF1 (zeige SRSF1 Antikörper) and the replicative helicase subunit MCM2 (zeige MCM2 Antikörper)
Thermodynamic analysis of the quaternary complex together with structural modeling support that ASF1 (zeige SRSF1 Antikörper) and MCM2 (zeige MCM2 Antikörper) could form a chaperoning module for histones H3 and H4 protecting them from promiscuous interactions.
Data indicate Tousled-like kinases (TLK1 (zeige TLK1 Antikörper)) phosphorylation has an impact on cell cycle proteins Asf1a and Asf1b (zeige ASF1B Antikörper) function.
findings show that ASF1A, a histone-remodeling chaperone specifically enriched in the metaphase II oocyte, is necessary for reprogramming of adult dermal fibroblasts into undifferentiated induced pluripotent stem cell
The ATR (zeige ANTXR1 Antikörper) checkpoint pathway causes a histone chaperone normally associated with the replication fork, ASF1a, to degrade through a CRL1 (zeige IL27RA Antikörper)(betaTRCP (zeige BTRC Antikörper))-dependent ubiquitination/proteasome pathway, leading to the localized dechromatinization and gene repression.
Co-depletion of the histone chaperones ASF1a and ASF1b (zeige ASF1B Antikörper) in human cells induces all hallmarks of alternative lengthening of telomeres in both primary and cancer cells.
tousled-like kinases play important roles in DNA repair, not only by modulation of chromatin assembly via Asf1 (zeige PEG3 Antikörper), but also by a more direct function in processing the ends of a tousled-like kinase via interaction with Rad9 (zeige RAD9A Antikörper).
This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair.
histone chaperone ASF1A , histone chaperone ASF1A-like , anti-silencing function 1 , anti-silencing function protein 1 homolog , histone chaperone ASF1 , ASF1 anti-silencing function 1 homolog A , ASF1 anti-silencing function 1-like protein A , CCG1-interacting factor A , anti-silencing function protein 1 homolog A , hAsf1 , hAsf1a , hCIA