ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 10 Proteine (ADAMTS10)

ADAMTS10 belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. Zusätzlich bieten wir Ihnen ADAMTS10 Antikörper (50) und ADAMTS10 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
ADAMTS10 224697 P58459
ADAMTS10 81794 Q9H324
Ratte ADAMTS10 ADAMTS10 314655  
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Showing 4 out of 4 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 70 Days
$13,984.89
Details
Escherichia coli (E. coli) Human Unkonjugiert 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$220.80
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Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$688.00
Details

ADAMTS10 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human ,

Weitere Proteine zu ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 10 (ADAMTS10) Interaktionspartnern

Mouse (Murine) ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 10 (ADAMTS10) Interaktionspartner

  1. ADAMTS10 is identified as a potential functional integrator of the Ikaros (zeige IKZF1 Proteine)-CtBP (zeige CTBP2 Proteine) chromatin remodeling network.

  2. these studies support the notion that sperm-oocyte interactions involve considerable functional redundancy and identify ADAMTS10 as a novel candidate in the mediation of these fundamentally important events.

  3. TGF-beta (zeige TGFB1 Proteine) stimulation of renal cells results in a significant up-regulation of Adams 10, 17, 12, and 19

  4. ADAMTS10 is a functional metalloprotease (zeige ADAMTS7 Proteine) as demonstrated by cleavage of alpha2-macroglobulin (zeige A2M Proteine)

Human ADAM Metallopeptidase with Thrombospondin Type 1 Motif, 10 (ADAMTS10) Interaktionspartner

  1. Using siRNA, over-expression and mutagenesis, it was found ADAMTS6 (zeige ADAMTS6 Proteine) inhibits and ADAMTS10 is required for focal adhesions, epithelial cell-cell junction formation, and microfibril deposition.

  2. These findings support the Gly661Arg mutation of ADAMTS10 as the likely cause of POAG in beagles.

  3. ADAMTS10 participates in microfibril biogenesis rather than in fibrillin-1 (zeige FBN1 Proteine) turnover

  4. ADAMTS10 is a functional metalloprotease as demonstrated by cleavage of alpha2-macroglobulin (zeige A2M Proteine)

  5. ADAMTS10 plays a major role in growth and in skin, lens, and heart development in humans.

  6. infer that folding of the complex C-terminal ancillary domain is the rate-limiting step in biosynthesis of ADAMTS10, and that it (but not catalytic domain) is sensitive to subtle changes in efficiency of signal peptide cleavage.

  7. Mutations in ADAMTS10 gene is not responsible for microspherophakia.

  8. Homozygous mutation in ADAMTS10 causes lenticular myopia, ectopia lentis, glaucoma, spherophakia, and short stature.

ADAMTS10 Protein Überblick

Protein Überblick

This gene belongs to the ADAMTS (a disintegrin and metalloproteinase domain with thrombospondin type-1 motifs) family of zinc-dependent proteases. ADAMTS proteases are complex secreted enzymes containing a prometalloprotease domain of the reprolysin type attached to an ancillary domain with a highly conserved structure that includes at least one thrombospondin type 1 repeat. They have been demonstrated to have important roles in connective tissue organization, coagulation, inflammation, arthritis, angiogenesis and cell migration. The product of this gene plays a major role in growth and in skin, lens, and heart development. It is also a candidate gene for autosomal recessive Weill-Marchesani syndrome.

Genbezeichner und Symbole assoziert mit ADAMTS10

  • a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 10 (Adamts10)
  • ADAM metallopeptidase with thrombospondin type 1 motif 10 (ADAMTS10)
  • ADAM metallopeptidase with thrombospondin type 1 motif, 10 (Adamts10)
  • 9430006O18 Protein
  • ADAM-TS10 Protein
  • ADAMTS-10 Protein
  • AW045948 Protein
  • WMS Protein
  • WMS1 Protein
  • Znmp Protein

Bezeichner auf Proteinebene für ADAMTS10

A disintegrin and metalloproteinase with thrombospondin motifs 10 , a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 10 , zinc metalloendopeptidase , ADAM-TS 10 , ADAM metallopeptidase with thrombospondin type 1 motif 10 , a disintegrin-like and metalloprotease with thrombospondin type 1 motif, 10

GENE ID SPEZIES
224697 Mus musculus
81794 Homo sapiens
611267 Canis lupus familiaris
100624519 Sus scrofa
513140 Bos taurus
314655 Rattus norvegicus
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