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ADAMTS1 encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Zusätzlich bieten wir Ihnen ADAMTS1 Antikörper (130) und ADAMTS1 Proteine (21) und viele weitere Produktgruppen zu diesem Protein an.
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Human ADAMTS1 ELISA Kit für Sandwich ELISA - ABIN415114
Tyan, Hsu, Peng, Chen, Kuo, Lee, Shew, Chang, Juan, Lee: Breast cancer cells induce stromal fibroblasts to secrete ADAMTS1 for cancer invasion through an epigenetic change. in PLoS ONE 2012
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The developmental arrest of early secondary follicles following furin (zeige FURIN ELISA Kits) disruption might be rooted in the loss of the mature form of ADAMTS1 and compromised proliferation of granulosa cells in mutant mice.
Energy expenditure and thermogenesis were not significantly different between KO and WT ADAMTS5 (zeige ADAMTS5 ELISA Kits)-J mice (in contrast to somewhat enhanced levels in ADAMTS5 (zeige ADAMTS5 ELISA Kits)-P mice). Insulin (zeige INS ELISA Kits) sensitivity was improved in the ADAMTS5 (zeige ADAMTS5 ELISA Kits)-J KO mice, and they were protected against non-alcoholic steatohepatitis in the DIO model
Data show that NOTCH1 (zeige NOTCH1 ELISA Kits) is a target of ADAMTS1 metalloproteinase activity, which reduces Notch (zeige NOTCH1 ELISA Kits) signaling, leading to increased satellite cell activation.
Reduced tumors in ADAMTS1 knockout mice displayed a paradoxical increase in vascular density and vascular-related genes; a detailed characterization revealed an impaired vasculature, along with a minor infiltration of macrophages. melanoma xenografts showed a relevant induction of its expression in stroma compartments.
Adamts1 acts as an extracellular matrix 'modifier', with miR (zeige MLXIP ELISA Kits)-181d-induced downregulation, that regulates adipocyte lineage commitment and obesity.
Adamts5 (zeige ADAMTS5 ELISA Kits)(-/-) mice were protected from hepatic mitochondrial dysfunction, as indicated by increased mitochondrial respiratory chain complex activity, higher ATP levels and higher expression of antioxidant enzymes. Absence of ADAMTS5 (zeige ADAMTS5 ELISA Kits) preserves liver integrity in a diet-induced obesity model.
Genetic haploinsufficiency of Adamts1 in mice caus (zeige NOS2 ELISA Kits)es thoracic aortic aneurysms and dissections similar to Marfan syndrome.
An ADAMTS1 blocking antibody suppressed the SPARC (zeige SPARC ELISA Kits)-induced collagen I secretion, indicating that SPARC (zeige SPARC ELISA Kits) promoted collagen production directly through ADAMTS1 interaction. In conclusion, ADAMTS1 is an important mediator of SPARC (zeige SPARC ELISA Kits)-regulated cardiac aging.
research emphasises the importance of ADAMTS5 (zeige ADAMTS5 ELISA Kits) expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5 (zeige ADAMTS5 ELISA Kits)-based therapeutic strategies to reduce morbidity and mortality
increased expression of ADAMTS1 protein in macrophages and neutrophils that infiltrated aortic tissues may promote the progression of acute aortic dissection
Our study demonstrated that altered levels of ADAMTS-1 and aggrecan (zeige ACAN ELISA Kits) may have a partial role in the etiopathogenesis of Polycystic ovary syndrome (PCOS), and ADAMTS-1 could be a predictive marker for implantation success in PCOS patients.
This study showed that ADAMTS1, 8, and 18 are highly expressed in GC and its nodal metastases, suggesting important roles of these proteases in carcinogenesis and lymphatic metastasis. The findings from the present study indicate that these proteases may be promising candidates for novel and alternative treatments in GC (gastric cancer)
Taken together, our findings suggested that miR (zeige MLXIP ELISA Kits)-362-3p inhibits the proliferation and migration of VSMCs by directly targeting ADAMTS1, which might provide novel insight into the molecular mechanisms underlying the action of miR (zeige MLXIP ELISA Kits)-362-3p in atherosclerosis.
ADAMTS1 has diverse roles in angiogenesis, tumor microenvironment and lymphangiogenesis.
Patients with Marfan syndrome showed elevated NOS2 and decreased ADAMTS1 protein levels in the aorta.
Data indicate that serum versican (zeige Vcan ELISA Kits) levels were significantly decreased in polycystic ovary syndrome (PCOS) patients, and that serum ADAMTS-1 (a disintegrin and metalloproteinase with thrombospondin motif-1) and versican (zeige Vcan ELISA Kits) levels were significantly and positively correlated with each other.
Findings indicate that ADAMTS-1 has proteolytic functions in the nucleus through its interaction with aggrecan (zeige ACAN ELISA Kits) substrate in normal and tumoral breast cells.
All ADAMTS (zeige ADAMTS13 ELISA Kits) tested in our study were expressed in both stable and unstable carotid plaques, especially in smooth muscle cells and macrophages. Analysis of the expression pattern on mRNA level showed significant higher expression of ADAMTS1 in unstable plaques compared with stable plaques.
ADAMTS1 protein levels in semen were significantly lower in males with infertility. Sperm count and motility showed a negative correlation with levels of ADAMTS1 protein expression.
Expression and induction of ADAMTS-1 through receptor-mediated action of progesterone in cumulus cells is one of essential requirements for gonadotropin-regulated cumulus expansion of porcine cumulus-oocyte complexes.
study indicates that disintegrin and metalloproteinase with thrombospondin motifs 1(ADAMTS1) participates in bovine endometrial remodeling
Data indicate that ADAMTS1 promoter activity and mRNA expression were increased by forskolin and human chorionic gonadotropin.
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function.
metalloproteinase with thrombospondin-like motifs-1
, ADAM metallopeptidase with thrombospondin type 1 motif, 1
, A disintegrin and metalloproteinase with thrombospondin motifs 1
, ADAM-TS 1
, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1
, A disintegrin and metalloproteinase with thrombospondin motifs 5
, ADAM-TS 5
, human metalloproteinase with thrombospondin type 1 motifs
, a disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS-1)
, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1
, a disintegrin-like and metallopeptidse (reprolysin type) with thrombospondin type 1 motif, 1