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anti-Mouse (Murine) FEN1 Antikörper:
anti-Human FEN1 Antikörper:
anti-Rat (Rattus) FEN1 Antikörper:
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Human Monoclonal FEN1 Primary Antibody für ICC, IF - ABIN151083
Qiu, Li, Frank, Shen: Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. in The Journal of biological chemistry 2001
Show all 17 Pubmed References
Human Polyclonal FEN1 Primary Antibody für IP, WB - ABIN151786
Muftuoglu, Wong, Imam, Wilson, Bohr, Opresko: Telomere repeat binding factor 2 interacts with base excision repair proteins and stimulates DNA synthesis by DNA polymerase beta. in Cancer research 2006
Show all 7 Pubmed References
Human Polyclonal FEN1 Primary Antibody für ICC, IF - ABIN151787
Farina, Shin, Kim, Bermudez, Kelman, Seo, Hurwitz: Studies with the human cohesin establishment factor, ChlR1. Association of ChlR1 with Ctf18-RFC and Fen1. in The Journal of biological chemistry 2008
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Dog (Canine) Monoclonal FEN1 Primary Antibody für BI, WB - ABIN968459
Harrington, Lieber: The characterization of a mammalian DNA structure-specific endonuclease. in The EMBO journal 1994
Show all 5 Pubmed References
Human Polyclonal FEN1 Primary Antibody für WB - ABIN2801955
Murray, Tavassoli, al-Harithy, Sheldrick, Lehmann, Carr, Watts: Structural and functional conservation of the human homolog of the Schizosaccharomyces pombe rad2 gene, which is required for chromosome segregation and recovery from DNA damage. in Molecular and cellular biology 1994
Show all 5 Pubmed References
Human Polyclonal FEN1 Primary Antibody für IP, WB - ABIN151078
Wang, Brandt, Rossi, Lindsey-Boltz, Podust, Fanning, Sancar, Bambara: The human Rad9-Rad1-Hus1 checkpoint complex stimulates flap endonuclease 1. in Proceedings of the National Academy of Sciences of the United States of America 2004
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Data show that shade avoidance 6 (SAV6; At5g26680), encodes flap endonuclease-1 (FEN1), assures proper root development through maintenance of genome integrity.
These results reveal an important role of FEN1 phosphorylation to counteract oxygen-induced stress in the heart during the fetal-to-neonatal transition.
WDR4 (zeige WDR4 Antikörper) regulates FEN1's potential DNA cleavage threat near the site of replication.
The FEN1 E359K germline mutation disrupts the FEN1-WRN interaction and FEN1 GEN (zeige GEN1 Antikörper) activity, causing aneuploidy-associated cancers.
PARP1 (zeige PARP1 Antikörper) is required for FEN1 recruitment to DNA repair intermediates in base excision repair.
FFAA Fen1 mutation causes defective Pcna (zeige PCNA Antikörper) -coordinated Okazaki fragment maturation.
A point mutation in the base excision repair gene flap endonuclease 1 causes a functional deficiency in repairing base damage, such that individuals carrying the mutation or similar mutations are predisposed to chemical-induced cancer development.
FEN1 localization within the mitochondrial compartment of mouse brain tissue
Distinct roles for two Mg2 (zeige MCOLN1 Antikörper)+ binding sites in the regulation of FEN-1 nuclease (zeige DCLRE1C Antikörper) activities include enhancement of DNA substrate binding ability and modulation of conformational changes.
FEN1 has roles in DNA repair, as well as in DNA replication
Fen1 is induced independently in mouse embryonic fibroblasts by ultraviolet (UV-C)light
Data indicate that human cancer-associated genetic alterations in the FEN1 gene can contribute substantially to cancer development.
WRN (zeige RECQL2 Antikörper) or the Bloom syndrome helicase (BLM) stimulates DNA polymerase delta (zeige POLD1 Antikörper) progression across telomeric G-rich repeats, only WRN (zeige RECQL2 Antikörper) promotes sequential strand displacement synthesis and FEN1 cleavage.
The FEN1 rs174538 A allele is a protective biomarker for childhood ALL and this association is more significant in males and in patients at onset age of 3.5 years or older.
Data indicate that Flap endonuclease 1 (FEN1) single nucleotide polymorphisms and haplotypes are associated with gallbladder cancer risk.
the aim of the present study was to determine the role of FEN1 in the chemosensitivity of SGC7901 cells.
Binding of DNA to human FEN1 in a bent conformation occurred independently of 5'-flap (zeige ALOX5AP Antikörper) accommodation and did not require active site metal ions or the presence of conserved active site residues.
In this study, we found that cohesion establishment factors, like CHlR1 (zeige DDX11 Antikörper), cooperatively stimulate endonuclease activity of hFen1 in in vivo mimic condition, including replication protein-A (zeige GPR153 Antikörper)-coated DNA and high salt.
Under DNA repair conditions, FEN1 efficiently repaired the 5'-phoshotyrosyl bond-containing SSB substrates in the presence of DNA ligase and DNA polymerase (zeige POLB Antikörper).
Patients with expression of both FEN1 and RAD54B (zeige RAD54B Antikörper) were prone to have advanced nodal involvement and significantly poor prognosis.
The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions.
flap endonuclease 1
, Flap structure-specific endonuclease 1
, flap structure-specific endonuclease 1
, DNase IV
, maturation factor 1
, maturation factor-1
, 5' nuclease xFEN1a
, flap endonuclease 1-A
, flap structure-specific endonuclease 1-A