anti-Maus SOS1 Antikörper für Immunoprecipitation

Recommended SOS1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Son of Sevenless Homolog 1 (Drosophila) (SOS1) Antikörper
  • GF1
  • GGF1
  • GINGF
  • HGF
  • NS4
  • 4430401P03Rik
  • 9630010N06
  • AI449023
  • son of sevenless homolog 1 (Drosophila)
  • Son of sevenless homolog 1 (Drosophila)
  • SOS1
  • Sos1
Epitop
AA 1-109
3
2
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Hund, Human, Maus, Ratte (Rattus)
52
33
12
8
7
7
7
6
5
4
3
3
1
1
Wirt
Maus
32
21
7
Klonalität
Monoklonal
Konjugat
Dieser SOS1 Antikörper ist unkonjugiert
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
43
21
20
13
7
6
2
1
1
Optionen
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Produktnummer ABIN967740
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN967741 IF IP IHC WB Mouse IgG1 AA 1-109 Anmelden zum Anzeigen 25-SOS1 5
1 ABIN210638 IP WB Rabbit IgG AA 1243-1258 Anmelden zum Anzeigen Polyclonal
1 ABIN2364688 IP WB Rabbit IgG AA 1243-1258 Anmelden zum Anzeigen Polyclonal
1 ABIN1937312 IP WB Rabbit IgG AA 1283-1333 Anmelden zum Anzeigen Polyclonal
1 ABIN1937311 IP Rabbit IgG AA 1025-1075 Anmelden zum Anzeigen Polyclonal

General

Antigen Son of Sevenless Homolog 1 (Drosophila) (SOS1) Antikörper
Epitop AA 1-109
(3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Hund, Human, Maus, Ratte (Rattus)
(52), (33), (12), (8), (7), (7), (7), (6), (5), (4), (3), (3), (1), (1)
Wirt Maus
(32), (21), (7)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser SOS1 Antikörper ist unkonjugiert
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(43), (21), (20), (13), (7), (6), (2), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-SOS1 Antikörper

Target Details SOS1 Anwendungsinformationen Handhabung Referenzen für anti-SOS1 Antikörper (ABIN967740) Bilder
Kreuzreaktivität Human, Hund, Ratte (Rattus)
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Mouse mSos1 aa. 1-109
Klon 25-SOS1
Isotyp IgG1

Target Details SOS1

Produktdetails anti-SOS1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-SOS1 Antikörper (ABIN967740) Bilder zurück nach oben
Antigen
Andere Bezeichnung Sos1 (SOS1 Antibody Abstract)
Hintergrund The Sos (son of sevenless) gene was originally identified in Drosophila, and two mammalian homologues (mSos1 and mSos2) were isolated from a mouse cDNA library. These two cDNAs predict proteins that are approximately 70% identical in their amino acid residues. Both mSos1 and mSos2 are expressed in a wide number of mouse embryonic and adult tissues as well as in several cell lines. The human homologues, hSos1 and hSos2 have also been isolated and show a very high degree of amino acid identity to the mouse genes (98% for Sos1). Sos1 has a predicted molecular weight of 150kDa, but the apparent molecular weight is closer to 170 kDa, presumably due to a high proline content. The mammalian Sos1 protein has a highly specific guanine nucleotide exchange activity toward p21ras . In EGF-stimulated cells, Sos1 interacts with the SH3 domains of GRB2, and GRB2 binds via its SH2 domain to tyrosine 1068 of the activated EGF receptor. Thus, GRB2 recruits Sos1 to the plasma membrane and enables it to activate the Ras signaling pathway by enhancing GTP loading on p21ras .
Molekulargewicht 170 kDa
Pathways RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor

Anwendungsinformationen

Produktdetails anti-SOS1 Antikörper Target Details SOS1 Handhabung Referenzen für anti-SOS1 Antikörper (ABIN967740) Bilder zurück nach oben
Kommentare

Related Products: ABIN968539, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-SOS1 Antikörper Target Details SOS1 Anwendungsinformationen Referenzen für anti-SOS1 Antikörper (ABIN967740) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.

Referenzen für anti-SOS1 Antikörper (ABIN967740)

Produktdetails anti-SOS1 Antikörper Target Details SOS1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Furuta, Miura, Copeland, Shang, Oshima, Kamata: "Light Chain 3 associates with a Sos1 guanine nucleotide exchange factor: its significance in the Sos1-mediated Rac1 signaling leading to membrane ruffling." in: Oncogene, Vol. 21, Issue 46, pp. 7060-6, 2002

Kardinal, Konkol, Lin, Eulitz, Schmidt, Estrov, Talpaz, Arlinghaus, Feller: "Chronic myelogenous leukemia blast cell proliferation is inhibited by peptides that disrupt Grb2-SoS complexes." in: Blood, Vol. 98, Issue 6, pp. 1773-81, 2001

Salojin, Zhang, Meagher, Delovitch: "ZAP-70 is essential for the T cell antigen receptor-induced plasma membrane targeting of SOS and Vav in T cells." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5966-75, 2000

Buday, Downward: "Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor." in: Cell, Vol. 73, Issue 3, pp. 611-20, 1993

Egan, Giddings, Brooks, Buday, Sizeland, Weinberg: "Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation." in: Nature, Vol. 363, Issue 6424, pp. 45-51, 1993

Bilder

Produktdetails anti-SOS1 Antikörper Target Details SOS1 Anwendungsinformationen Handhabung Referenzen für anti-SOS1 Antikörper (ABIN967740) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Son of Sevenless Homolog 1 (Drosophila) (SOS1) (AA 1-109) antibody (ABIN967740) Western blot analysis of Sos1 on PC12 lysate. Lane 1: 1:250, lane 2: 1:500, lane 3: 1...