SOS1 Antikörper

Produktnummer ABIN238504

Dieser Maus Monoklonal Antikörper detektiert spezifisch SOS1 in WB, IF und EIA. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für SOS1 Antikörper (ABIN238504)

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOS1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)

Klon: SOS-1

Produktdetails anti-SOS1 Antikörper

Spezifität: The antibody SOS-01 reacts with human Sos, an ubiquitously expressed 150 kDa intracellular protein.

Produktmerkmale: Synonyms: SOS-1, Son of sevenless homolog 1

Aufreinigung: Protein A affinity chromatography.

Immunogen: Peptide corresponding to amino acids THPSMHRDGPPLLENAHSS of human Sos protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blotting under reducing conditions (1 μg/mL): Positive control: HeLa human cervix carcinoma cell line. Immunocytochemistry. ELISA.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, pH 7.4 with 15 mM sodium azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid freeze/thaw cycles.
Shelf life: One year from despatch.

Haltbarkeit: 12 months

Details zu SOS1

Target: SOS1 (Son of Sevenless Homolog 1 (SOS1))

Andere Bezeichnung: SOS1

Hintergrund: The guanine nucleotide exchange factor Sos (Son-of-sevenless) is a complex multidomain protein that activates the small GTPase Ras (H-Ras, K-Ras, N-Ras, but not functionally distinct R-Ras) in response to receptor tyrosine kinase stimulation. Nucleotide exchange activity of Sos is stimulated by allosteric Ras binding. By another (separable) guanine exchange factor domain domain Sos modulates activity of Rac/Rho GTPases. Sos thus integrates signals that affect both gene expression and cytoskeletal reorganization, the Sos-mediated Ras-activation and Rac activation differ in composition and stability of the formed complex.Synonyms: SOS-1, Son of sevenless homolog 1

Gen-ID: 6654

UniProt: Q07889

Pathways: RTK Signalweg, T-Zell Rezeptor Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Hepatitis C, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling