anti-Maus DDR2 Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended DDR2 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Antikörper
  • DDR2
  • ddr2
  • si:ch211-193c2.1
  • AW495251
  • Ntrkr3
  • tyro10
  • MIG20a
  • NTRKR3
  • TKT
  • TYRO10
  • Tyro10
  • discoidin domain receptor tyrosine kinase 2
  • discoidin domain receptor family, member 2b
  • discoidin domain receptor family, member 2
  • DDR2
  • ddr2b
  • LOC100356982
  • Ddr2
Epitop
AA 1-399
16
15
13
12
11
6
3
2
2
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Maus
100
35
6
1
1
Wirt
Kaninchen
76
48
Klonalität
Polyklonal
Konjugat
Dieser DDR2 Antikörper ist unkonjugiert
4
4
4
4
4
4
3
3
3
3
3
3
3
Applikation
ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
86
57
39
30
17
12
5
3
2
2
1
1
Hersteller
Anmelden zum Anzeigen
Hersteller Produkt- Nr.
Anmelden zum Anzeigen
Request

Produkt kostenlos erhalten?

Für Ihre Validierungsdaten erstatten wir Ihnen den vollen Kaufpreis. Ich möchte dieses Produkt validieren

Mehr erfahren

Bilder

Produktnummer ABIN2001101
$ 218.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
14.066996 ABIN4304587 IHC IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal
14.066996 ABIN4304588 FACS IHC IHC (p) WB Rabbit IgG Center Anmelden zum Anzeigen Polyclonal
1 ABIN755218 IF (p) IHC (p) WB Rabbit IgG AA 275-320 Anmelden zum Anzeigen Polyclonal 2
1 ABIN2855450 IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN2855418 FACS IHC (p) IHC WB Rabbit IgG Center Anmelden zum Anzeigen Polyclonal
1 ABIN658537 IHC (p) WB Rabbit Ig AA 816-843, C-Term Anmelden zum Anzeigen Polyclonal
1 ABIN4901384 ELISA IHC (p) Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN1811518 IHC (p) WB Rabbit AA 816-843 Anmelden zum Anzeigen Polyclonal

General

Antigen Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) Antikörper
Epitop AA 1-399
(16), (15), (13), (12), (11), (6), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Maus
(100), (35), (6), (1), (1)
Wirt Kaninchen
(76), (48)
Klonalität
Polyklonal
Konjugat Dieser DDR2 Antikörper ist unkonjugiert
(4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3)
Applikation ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(86), (57), (39), (30), (17), (12), (5), (3), (2), (2), (1), (1)
Pubmed 2 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-DDR2 Antikörper

Target Details DDR2 Anwendungsinformationen Handhabung Referenzen für anti-DDR2 Antikörper (ABIN2001101) Bilder
Spezifität Mouse DDR2
Produktmerkmale Produced in rabbits immunized with purified, recombinant Mouse DDR2 (rM DDR2, ABIN2007949 NP_072075.2, Met 1-Arg 399,. DDR2 specific IgG was purified by Mouse DDR2 affinity chromatography.
Reinigung purified by affinity chromatography
Sterilität 0.2 μm filtered
Immunogen Recombinant Mouse DDR2 protein (ABIN2007949)
Isotyp IgG

Target Details DDR2

Produktdetails anti-DDR2 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-DDR2 Antikörper (ABIN2001101) Bilder zurück nach oben
Antigen
Andere Bezeichnung DDR2 (DDR2 Antibody Abstract)
Hintergrund Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple- helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.
NCBI Accession NP_072075.2
Forschungsgebiet Cardiovascular, Cardiogenesis
Pathways RTK Signalweg

Anwendungsinformationen

Produktdetails anti-DDR2 Antikörper Target Details DDR2 Handhabung Referenzen für anti-DDR2 Antikörper (ABIN2001101) Bilder zurück nach oben
Applikationshinweise ELISA: 0.1-0.2 μg/mL
This antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Mouse DDR2. The detection limit for Mouse DDR2 is approximately 0.039 ng/well.
IHC-P: 0.1-2 μg/mL
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-DDR2 Antikörper Target Details DDR2 Anwendungsinformationen Referenzen für anti-DDR2 Antikörper (ABIN2001101) Bilder zurück nach oben
Format Liquid
Buffer 0.2 μm filtered solution in PBS with 5 % trehalose
Konservierungsmittel Without preservative
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung 4 °C,-20 °C,-80 °C
Informationen zur Lagerung This antibody can be stored at 2°C-8°C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20°C to -80°C. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Haltbarkeit 12 months

Referenzen für anti-DDR2 Antikörper (ABIN2001101)

Produktdetails anti-DDR2 Antikörper Target Details DDR2 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Zhang, Ding, Zhang, Su, Li, Liu, Ma, Yao: "Expression of discoidin domain receptor 2 (DDR2) extracellular domain in pichia pastoris and functional analysis in synovial fibroblasts and NIT3T3 cells." in: Molecular and cellular biochemistry, Vol. 290, Issue 1-2, pp. 43-53, 2006

Leitinger, Steplewski, Fertala: "The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2." in: Journal of molecular biology, Vol. 344, Issue 4, pp. 993-1003, 2004

Bilder

Produktdetails anti-DDR2 Antikörper Target Details DDR2 Anwendungsinformationen Handhabung Referenzen für anti-DDR2 Antikörper (ABIN2001101) zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 1-399) antibody (ABIN2001101) anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 1-399) antibody
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 1-399) antibody (ABIN2001101) anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) (AA 1-399) antibody (Image 2)