DDR2 Antikörper (Discoidin Domain Receptor tyrosine Kinase 2)

Details for Product anti-DDR2 Antibody No. ABIN969083, Anbieter: Anmelden zum Anzeigen
Antigen
  • MIG20a
  • NTRKR3
  • TKT
  • TYRO10
  • AW495251
  • Ntrkr3
  • tyro10
  • DDR2
  • Tyro10
  • ddr2
  • si:ch211-193c2.1
  • discoidin domain receptor tyrosine kinase 2
  • discoidin domain receptor family, member 2
  • discoidin domain receptor family, member 2, like
  • DDR2
  • Ddr2
  • ddr2l
Reaktivität
Human
99
43
8
1
1
Wirt
Maus
86
39
Klonalität (Klon)
Monoklonal ()
Konjugat
Dieser DDR2 Antikörper ist unkonjugiert
5
5
5
4
4
4
2
2
2
2
2
2
2
Applikation
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
94
64
46
23
19
11
4
4
3
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen Purified recombinant fragment of human DDR2 expressed in E. Coli.
Klon 3B11E4
Isotyp IgG2a
Reinigung Ascites
Plasmids, Primers & others Plasmide, Primers & weitere DDR2 products on genomics-online (e.g. as negative or positive controls)
Antigen Discoidin Domain Receptor tyrosine Kinase 2 (DDR2)
Andere Bezeichnung DDR2 (DDR2 Antibody Abstract)
Hintergrund DDR2 (discoidin domain receptor family, member 2) is one of the largest families of proteins in eukaryotes. The family has been classified in 8 major groups based on sequence comparison of their tyrosine (PTK) or serine/ threonine (STK) kinase catalytic domains. Receptor tyrosine kinases (RTKs) play a key role in the communication of cells with their microenvironment. These molecules are involved in the regulation of cell growth, differentiation, and metabolism. In several cases the biochemical mechanism by which RTKs transduce signals across the membrane has been shown to be ligand induced receptor oligomerization and subsequent intracellular phosphorylation. This autophosphorylation leads to phosphorylation of cytosolic targets as well as association with other molecules, which are involved in pleiotropic effects of signal transduction. RTKs have a tripartite structure with extracellular, transmembrane, and cytoplasmic regions. This gene encodes a member of a novel subclass of RTKs and contains a distinct extracellular region encompassing a factor VIII-like domain. Alternative splicing in the 5' UTR results in multiple transcript variants encoding the same protein.
Gen-ID 4921
HGNC 4921
Pathways RTK Signalweg
Applikations-hinweise ELISA: 1:10000, WB: 1:500 - 1:2000, IHC: 1:200 - 1:1000, ICC: 1:200 - 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung 4°C, -20°C for long term storage
Bilder des Herstellers
Immunocytochemistry (ICC) image for anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) antibody (ABIN969083) Figure 1: Confocal immunofluorescence analysis of A549 cells using DDR2 mouse mAb (gr...
Immunohistochemistry (IHC) image for anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) antibody (ABIN969083) Figure 2: Immunohistochemical analysis of paraffin-embedded human skeletal musle tiss...
Western Blotting (WB) image for anti-Discoidin Domain Receptor tyrosine Kinase 2 (DDR2) antibody (ABIN969083) Figure 3: Western blot analysis using DDR2 mouse mAb against truncated DDR2 recombina...
Produkt verwendet in: Leitinger, Kwan: "The discoidin domain receptor DDR2 is a receptor for type X collagen." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 25, Issue 6, pp. 355-64, 2006 (PubMed).

Shyu, Chao, Wang, Kuan: "Regulation of discoidin domain receptor 2 by cyclic mechanical stretch in cultured rat vascular smooth muscle cells." in: Hypertension, Vol. 46, Issue 3, pp. 614-21, 2005 (PubMed).

Neale, Kenny, Gershwin: "Cloning and sequencing of protein kinase cDNA from harbor seal (Phoca vitulina) lymphocytes." in: Clinical & developmental immunology, Vol. 11, Issue 2, pp. 157-63, 2004 (PubMed).

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