anti-Ratte (Rattus) AXL Antikörper für Flow Cytometry

Recommended AXL Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
AXL Receptor tyrosine Kinase (AXL) Antikörper
  • JTK11
  • UFO
  • AI323647
  • Ark
  • Tyro7
  • Ufo
  • AXL receptor tyrosine kinase
  • Axl receptor tyrosine kinase
  • AXL
  • Axl
Epitop
AA 180-230
28
24
19
18
18
15
14
12
12
11
10
9
8
6
6
6
6
5
5
5
4
4
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
248
105
63
6
2
2
1
1
1
1
Wirt
Kaninchen
173
83
33
4
1
Klonalität
Polyklonal
Konjugat
Dieser AXL Antikörper ist konjugiert mit PE
13
12
10
8
8
7
7
7
6
6
6
6
6
4
2
2
2
2
2
2
2
2
2
2
2
2
2
2
Applikation
Flow Cytometry (FACS)
185
107
85
54
30
26
14
10
7
6
2
2
2
1
1
1
1
1
1
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Produktnummer ABIN756032
436,70 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN756047 FACS PE Rabbit IgG pTyr698, pTyr702, pTyr703 Anmelden zum Anzeigen Polyclonal

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Applikation / Reaktivität Human Ratte (Rattus) Maus
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Simple Western (SimWes) 1 Antikörper
Western Blotting (WB) 161 Antikörper 53 Antikörper 33 Antikörper
RNA Interference (RNAi) 2 Antikörper
Immunoprecipitation (IP) 9 Antikörper 5 Antikörper 6 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 30 Antikörper 8 Antikörper 8 Antikörper
Immunohistochemistry (IHC) 52 Antikörper 8 Antikörper 10 Antikörper
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 26 Antikörper

General

Antigen AXL Receptor tyrosine Kinase (AXL) Antikörper
Epitop AA 180-230
(28), (24), (19), (18), (18), (15), (14), (12), (12), (11), (10), (9), (8), (6), (6), (6), (6), (5), (5), (5), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(248), (105), (63), (6), (2), (2), (1), (1), (1), (1)
Wirt Kaninchen
(173), (83), (33), (4), (1)
Klonalität
Polyklonal
Konjugat Dieser AXL Antikörper ist konjugiert mit PE
(13), (12), (10), (8), (8), (7), (7), (7), (6), (6), (6), (6), (6), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation Flow Cytometry (FACS)
(185), (107), (85), (54), (30), (26), (14), (10), (7), (6), (2), (2), (2), (1), (1), (1), (1), (1), (1)
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Produktdetails anti-AXL Antikörper

Target Details AXL Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human AXL
Isotyp IgG

Target Details AXL

Produktdetails anti-AXL Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Axl (AXL Antibody Abstract)
Hintergrund

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factor GAS6 and which is thus regulating many physiological processes including cell survival, cell proliferation, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of AXL. Following activation by ligand, ALX binds and induces tyrosine phosphorylation of PI3-kinase subunits PIK3R1, PIK3R2 and PIK3R3, but also GRB2, PLCG1, LCK and PTPN11. Other downstream substrate candidates for AXL are CBL, NCK2, SOCS1 and TENC1. Recruitment of GRB2 and phosphatidylinositol 3 kinase regulatory subunits by AXL leads to the downstream activation of the AKT kinase. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response. In case of filovirus infection, seems to function as a cell entry factor.

Subcellular location: Extracellular


Synonyms: UFO, JTK11, Tyrosine-protein kinase receptor UFO, AXL oncogene, AXL
Gen-ID 558
UniProt P30530
Pathways RTK Signalweg, Cellular Response to Molecule of Bacterial Origin

Anwendungsinformationen

Produktdetails anti-AXL Antikörper Target Details AXL Handhabung Bilder zurück nach oben
Applikationshinweise FCM(1:20-100)
Kommentare

Exitation/Emission: 480,565nm/578nm

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-AXL Antikörper Target Details AXL Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at 4°C
Haltbarkeit 12 months