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anti-SH2 Domain Protein 1A (SH2D1A) Antikörper

Bezeichnung:
anti-SH2 Domain Protein 1A Antikörper (SH2D1A)
Auf www.antikoerper-online.de finden Sie aktuell 6 SH2 Domain Protein 1A (SH2D1A) Antikörper von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SH2 Domain Protein 1A Kits (12) und SH2 Domain Protein 1A Proteine (8) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 29 SH2 Domain Protein 1A Produkte verfügbar.
Synonyme:
DSHP, EBVS, Gm686, IMD5, LYP, MTCP1, RGD1562408, SAP, SAP/SH2D1A, XLP, XLPD

Meistgesuchte Reaktivitäten zu anti-SH2 Domain Protein 1A (SH2D1A) Antikörper

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Am meisten referenzierte anti-SH2 Domain Protein 1A Antikörper

  1. Human Polyclonal SH2D1A Primary Antibody für WB - ABIN306863 : Tangye, Lazetic, Woollatt, Sutherland, Lanier, Phillips: Cutting edge: human 2B4, an activating NK cell receptor, recruits the protein tyrosine phosphatase SHP-2 and the adaptor signaling protein SAP. in Journal of immunology (Baltimore, Md. : 1950) 1999 (PubMed)
    Zeige alle 4 Referenzen für ABIN306863

Weitere Antikörper gegen SH2 Domain Protein 1A Interaktionspartner

Human SH2 Domain Protein 1A (SH2D1A) Interaktionspartner

  1. High LAT1 (zeige LAT Antikörper) expression correlated with significantly shorter prostate specific antigen (zeige KLK3 Antikörper) recurrence-free survival in patients receiving androgen deprivation therapy

  2. We describe here a novel c.137+5G > A intronic mutation in the SH2D1A gene of the signaling lymphocyte activation molecule (SLAM (zeige SLAMF1 Antikörper))-associated protein (SAP) in association with Epstein-Barr virus (EBV)-induced fatal infectious mononucleosis (FIM (zeige ZMYM2 Antikörper)) in an 8-year-old male patient and his 3-year-old step brother. The mother and the maternal grandmother of the boys are healthy and heterozygous for this sequence variant.

  3. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  4. The mutation c.131G>A in this patient was found in combination with a second SH2D1A mutation

  5. Study of SAP (zeige APCS Antikörper) expression is specific but may have insufficient sensitivity for screening XLP1 as a single tool; however, combination with 2B4 (zeige CD244 Antikörper) functional assay allows identification of all cases

  6. Molecular dynamics analysis revealed that mutant R32Q and T53I structures of SAP (zeige APCS Antikörper) exhibited structural variation with respect to their backbone atoms before and after binding with the unphosphorylated SLAM (zeige SLAMF1 Antikörper) peptide.

  7. Signaling lymphocytic activation molecule (SLAM)/SLAM (zeige SLAMF1 Antikörper)-associated protein pathway regulates human B-cell tolerance.

  8. In patients suffering from X-linked lymphoproliferative disease (XLP1), SAP (zeige APCS Antikörper) is nonfunctional, not only abolishing the activating function of 2B4 (zeige CD244 Antikörper), but rendering this receptor inhibitory.

  9. our data reveal how SAP (zeige APCS Antikörper) nucleates a previously unknown signaling complex involving NTB-A (zeige SLAMF6 Antikörper) and LCK (zeige LCK Antikörper) to potentiate restimulation-induced cell death of activated human T cells.

  10. SAP (zeige APCS Antikörper) is a new actor downstream of PECAM-1 (zeige PECAM1 Antikörper) and its binding regulates PECAM-1 (zeige PECAM1 Antikörper) mediated cell adhesion.

Mouse (Murine) SH2 Domain Protein 1A (SH2D1A) Interaktionspartner

  1. SAP (zeige APCS Antikörper) is an essential molecule for autoimmune antibody production.

  2. In addition to their role in NK cell activation by hematopoietic cells, the SLAM-SAP-SHP1 pathways influence responsiveness toward nonhematopoietic targets by a process akin to NK cell 'education'.

  3. SLAM (zeige SLAMF1 Antikörper)-SAP (zeige APCS Antikörper) signaling promotes differentiation of IL-17 (zeige IL17A Antikörper)-producing T cells and progression of experimental autoimmune encephalomyelitis.

  4. these data suggest that SAP (zeige APCS Antikörper) is critical for regulating type II NKT (zeige CTSL1 Antikörper) cell responses.

  5. functional analysis in vitro indicates that SAP-2 is a non-functional isoform due to decreased protein stability

  6. Here we report that B cell intrinsic responses to haptenated protein antigens are impaired in SAP (zeige APCS Antikörper)-/- mice and in Rag-/- mice into which B cells derived from SAP (zeige APCS Antikörper)-/- mice together with wt CD4 (zeige CD4 Antikörper)+ T cells had been transferred.

  7. SAP (zeige APCS Antikörper) plays an essential role in CIA (zeige NCOA5 Antikörper) because of Fyn (zeige FYN Antikörper)-independent and Fyn (zeige FYN Antikörper)-dependent effects on TFH cells and, possibly, other T cell types.

  8. SAP (zeige APCS Antikörper) was required not only for the initiation but also for the progression of primary T cell-driven B cell responses to haptens.

  9. Loss of SAP (zeige APCS Antikörper) expression is associated with invariant NKT (zeige CTSL1 Antikörper) cell cytotoxicity and defective lytic synapse formation.

  10. SAP (zeige APCS Antikörper) is required for the development of innate phenotype in H2-M3--restricted Cd8 (zeige CD8A Antikörper)(+) T cells.

SH2 Domain Protein 1A (SH2D1A) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with SH2 Domain Protein 1A (SH2D1A)

  • amyloid P component, serum (Apcs) Antikörper
  • SH2 domain containing 1A (SH2D1A) Antikörper
  • SH2 domain containing 1A (Sh2d1a) Antikörper
  • SH2 domain protein 1A (Sh2d1a) Antikörper
  • DSHP Antikörper
  • EBVS Antikörper
  • Gm686 Antikörper
  • IMD5 Antikörper
  • LYP Antikörper
  • MTCP1 Antikörper
  • RGD1562408 Antikörper
  • SAP Antikörper
  • SAP/SH2D1A Antikörper
  • XLP Antikörper
  • XLPD Antikörper

Bezeichner auf Proteinebene für SH2D1A

serum amyloid P-component , Duncan disease SH2-protein , SH2 domain-containing protein 1A , SLAM associated protein/SH2 domain protein 1A , SLAM-associated protein , T cell signal transduction molecule SAP , T-cell signal transduction molecule SAP , signaling lymphocyte activation molecule-associated protein , signaling lymphocytic activation molecule-associated protein , SH2 domain protein 1A , Duncan disease homolog

GENE ID SPEZIES
29339 Rattus norvegicus
4068 Homo sapiens
501502 Rattus norvegicus
20400 Mus musculus
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