SH2D1A Antikörper (C-Term)

Produktnummer ABIN2788421

Der Kaninchen Polyklonal anti-SH2D1A Antikörper wird verwendet zum Nachweis von SH2D1A in Proben von Human, Ratte, Rind (Kuh), Schwein und Pferd. Er wurde validiert für WB.

Kurzübersicht für SH2D1A Antikörper (C-Term) (ABIN2788421)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Reaktivität: Human, Ratte, Rind (Kuh), Schwein, Pferd

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SH2D1A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-SH2D1A Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: SH2D1A Antibody - C-terminal region

Sequenz: YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL

Homologie: Cow: 86%, Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%

Produktmerkmale: This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP60359-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu SH2D1A

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Andere Bezeichnung: SH2D1A

Hintergrund:

Background Information: SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.

Gene Name: SH2 domain containing 1A

Alternative Symbols: LYP, SAP, XLP, DSHP, EBVS, IMD5, XLPD, MTCP1, XLPD1, SAP/SH2D1A

Protein Name: SH2 domain-containing protein 1A

Molekulargewicht: 14kDa

Gen-ID: 4068

NCBI Accession: NP_002342

UniProt: O60880

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process