SH2 Domain Containing 1A (SH2D1A) (C-Term) Antikörper

Details zu Produkt Nr. ABIN2788421, Anbieter: Anmelden zum Anzeigen
Antigen
  • DSHP
  • EBVS
  • IMD5
  • LYP
  • MTCP1
  • SAP
  • SAP/SH2D1A
  • XLP
  • XLPD
  • RGD1562408
  • Gm686
  • SH2D1A
  • SH2 domain containing 1A
  • SH2D1A
  • Sh2d1a
Epitop
C-Term
18
16
16
9
8
5
4
3
2
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Pferd, Human, Schwein, Ratte (Rattus)
114
38
32
7
6
4
2
1
1
1
1
Wirt
Kaninchen
71
33
14
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
7
7
6
5
5
5
1
1
1
1
1
1
1
1
1
1
1
Applikation
Western Blotting (WB)
101
61
13
10
5
4
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the C terminal region of human SH2D1A
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN983683.
Sequenz YFRKIKNLIS AFQKPDQGIV IPLQYPVEKK SSARSTQGTT GIREDPDVCL
Homologie Cow: 86%, Horse: 92%, Human: 100%, Pig: 100%, Rat: 93%
Produktmerkmale This is a rabbit polyclonal antibody against SH2D1A. It was validated on Western Blot.
Reinigung Affinity Purified
Andere Bezeichnung SH2D1A (SH2D1A Antibody Abstract)
Hintergrund SH2D1A is a protein that plays a major role in the bidirectional stimulation of T and B cells. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in SH2D1A gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma.
Alias Symbols: DSHP, EBVS, FLJ18687, FLJ92177, IMD5, LYP, MTCP1, SAP, XLP, XLPD, SAP/SH2D1A
Protein Interaction Partner: LHX4, TNK2, UBC, LYN, MAPK11, MAPK1, ERBB3, EGFR, MAPK14, CD244, ELAVL1, SLAMF7, SLAMF6, ARHGEF7, CD84, SLAMF1, DOK1, FYB, LY9, ARHGEF6, LCK, FYN, GRB2,
Protein Size: 128
Molekulargewicht 14 kDa
Gen-ID 4068
NCBI Accession NM_002351, NP_002342
UniProt O60880
Pathways Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 128 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) antibody (ABIN2788421) WB Suggested Anti-SH2D1A Antibody Titration: 0.2-1 ug/ml
ELISA Titer:
Western Blotting (WB) image for anti-SH2 Domain Containing 1A (SH2D1A) (C-Term) antibody (ABIN2788421) WB Suggested Anti-SH2D1A
Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500...
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