Interleukin 15 (IL15) (AA 49-162), (full length) protein (His tag)

Details zu Produkt Nr. ABIN1047241, Anbieter: Anmelden zum Anzeigen
Proteinname
  • IL15
  • AI503618
  • IL-15
  • interleukin 15
  • IL15
  • Il15
Proteineigenschaft
AA 49-162, full length
30
3
2
2
2
2
1
1
1
1
Spezies
Human
66
25
14
3
3
3
2
2
1
1
1
1
1
1
Quelle
Escherichia coli (E. coli)
94
11
7
3
1
Protein-Typ
Recombinant
Aufreinigungstag / Konjugat
Dieses IL15 Protein ist gelabelt mit His tag.
Applikation
ELISA
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Sequenz NWVNVISDLK KIEDLIQSMH IDATLYTESD VHPSCKVTAM KCFLLELQVI SLESGDASIH DTVENLIILA NNSLSSNGNV TESGCKECEE LEEKNIKEFL QSFVHIVQMF INTS
Produktmerkmale Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Reinheit 90 %
Hintergrund Cytokine that stimulates the proliferation of T-lymphocytes. Stimulation by IL-15 requires interaction of IL-15 with components of IL-2R, including IL-2R beta and probably IL-2R gamma but not IL-2R alpha.
Molekulargewicht 16.9 kD
UniProt P40933
Pathways JAK-STAT Signalweg, Glycosaminoglycan Metabolic Process
Kommentare

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Lyophilized
Konzentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handhabung Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Lagerung -20 °C
Informationen zur Lagerung Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Bilder des Herstellers
SDS-PAGE (SDS) image for Interleukin 15 (IL15) (AA 49-162), (full length) protein (His tag) (ABIN1047241) Interleukin 15 (IL15) (AA 49-162), (full length) protein (His tag)
Allgemeine Veröffentlichungen Tagaya, Kurys, Thies, Losi, Azimi, Hanover, Bamford, Waldmann: "Generation of secretable and nonsecretable interleukin 15 isoforms through alternate usage of signal peptides." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 26, pp. 14444-9, 1998 (PubMed).

Krause, Jandrig, Wernicke, Bulfone-Paus, Pohl, Diamantstein: "Genomic structure and chromosomal localization of the human interleukin 15 gene (IL-15)." in: Cytokine, Vol. 8, Issue 9, pp. 667-74, 1997 (PubMed).

Meazza, Verdiani, Biassoni, Coppolecchia, Gaggero, Orengo, Colombo, Azzarone, Ferrini: "Identification of a novel interleukin-15 (IL-15) transcript isoform generated by alternative splicing in human small cell lung cancer cell lines." in: Oncogene, Vol. 12, Issue 10, pp. 2187-92, 1996 (PubMed).

Grabstein, Eisenman, Shanebeck, Rauch, Srinivasan, Fung, Beers, Richardson, Schoenborn, Ahdieh: "Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor." in: Science (New York, N.Y.), Vol. 264, Issue 5161, pp. 965-8, 1994 (PubMed).