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anti-Human GRF2 Antikörper:
anti-Mouse (Murine) GRF2 Antikörper:
anti-Rat (Rattus) GRF2 Antikörper:
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Human Monoclonal GRF2 Primary Antibody für IA, IP - ABIN2192053
Lachmann, Oldroyd, Milstein, Wright: Three rat monoclonal antibodies to human C3. in Immunology 1981
Show all 2 Pubmed References
Human Monoclonal GRF2 Primary Antibody für ELISA, WB - ABIN561125
Nolz, Nacusi, Segovis, Medeiros, Mitchell, Shimizu, Billadeau: The WAVE2 complex regulates T cell receptor signaling to integrins via Abl- and CrkL-C3G-mediated activation of Rap1. in The Journal of cell biology 2008
C3G stimulates guanine nucleotide exchange on Drosophila Rap (zeige LRPAP1 Antikörper) GTPases in vitro
the N terminus of C(3)G is critical for the formation of antiparallel pairs of C(3)G homodimers that span the central region and thus for assembly of complete TFs, while the C terminus is required to affix these homodimers to the lateral elements.
C3G/RAP1 activity is involved in the metastatic spread of epithelial ovarian cancer.
C3G plays an important role in platelet clotting through a mechanism involving its GEF (zeige SLC2A4RG Antikörper) activity and suggest that it might be also involved in neutrophil development.
The possibility of cellular phospho-C3G (pC3G) being a substrate of the intracellular T-cell protein tyrosine phosphatase TC-PTP (zeige PTPN2 Antikörper) (PTPN2 (zeige PTPN2 Antikörper)) using the human neuroblastoma (zeige ARHGEF16 Antikörper) cell line, was studied.
Lyn (zeige LYN Antikörper) controls spatial activation of Rap1 (zeige RABGEF1 Antikörper) by recruiting the CrkL (zeige CRKL Antikörper)-C3G protein complex to the leading edge
found somatic demethylation of a relaxed-criterion CpG island (CGI-B) located in the first intron of RAPGEF1 in 40% of colon cancers and 8% of gastric cancers relative to their matching normal tissues that were always methylated
Data demonstrated that the polymorphism in TP53 (zeige TP53 Antikörper) (rs1042522) was associated with type 2 diabetes, and that potential interaction of TP53 (zeige TP53 Antikörper) (rs1042522) and RAPGEF1 (rs11243444), or NRF1 (zeige NFE2L1 Antikörper) (rs1882095) increased the risk of type 2 diabetes.
significant positive correlation between layers II and IV of the dorso-lateral prefrontal cortex in the percentage of MR-GEF expressing neurons in individuals with bipolar disorder
C3G overexpression induces neurite-like extensions in MDA-MB-231 and BT549 breast carcinoma cells and not in a variety of other cancer cell lines examined.
C3G as a novel target of c-Abl
ALK (zeige ALK Antikörper) activation of Rap1 (zeige RABGEF1 Antikörper) via the Rap1 (zeige RABGEF1 Antikörper)-specific GEF (zeige SLC2A4RG Antikörper) C3Gmay contribute to cell proliferation and oncogenesis of neuroblastoma (zeige ARHGEF16 Antikörper).
C3G is required in cortical neurons for both the specification of an axon and the initiation of radial migration by forming a leading process.
results provide evidence that C3G plays an important role in myogenic differentiation by coordinating cell cycle exit, actin dynamics and survival signaling.
C3G regulates sympathetic preganglionic neuron migration by acting downstream in the reelin (zeige RELN Antikörper) signaling pathway.
Data indicate that chemical rescue of c-Src provided a tool to dissect the spatiotemporal mechanism of activation of the Rap1 guanine exchange factor, C3G, one of the identified potential c-Src substrates that plays a role in focal adhesion signaling.
GEF and Dlx1/2 form part of a common signalling pathway during GABAergic neuronal development.
Guanine nucleotide releasing factor 2 (zeige RASGRF2 Antikörper) is a negative regulator of Mitogen-Activated Protein Kinase 14 (zeige MAPK14 Antikörper) in mouse embryonic fibroblasts and can promote cell survival or cell death depending on the stimuli.
Targeted disruption of Ras-Grf2 (zeige RASGRF2 Antikörper) shows its dispensability for mouse growth and development.
These results show that C3G is required for (1) vascular myogenesis, (2) the formation of paxillin (zeige PXN Antikörper)- and integrin beta1-positive, but not integrin beta3-positive, cell adhesions and (3) normal response to PDGF (zeige PDGFA Antikörper), necessary for vascular myogenesis.
roles of C3G-Rap1 signaling pathway in various biological processes
Our results show that the size of the cortical neural precursor population is controlled by C3G-mediated inhibition of the Ras signalling pathway.
the SSC5:60296617 SNP may affect teat number by regulating the interaction of EPS8 (zeige EPS8 Antikörper) and RAPGEF1 and, finally, affecting the mammogenesis of pigs
This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
, guanine nucleotide-releasing factor 2
, rap guanine nucleotide exchange factor 1
, Rap guanine nucleotide exchange factor (GEF) 1
, rap guanine nucleotide exchange factor 1-like
, CRK SH3-binding GNRP
, guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene)
, guanine nucleotide releasing factor 2
, rap guanine nucleotide exchange factor-like 1