GRF2 Antikörper (C-Term)

Produktnummer ABIN2785868

Produktdetails anti-GRF2 Antikörper

Target: GRF2 (RAPGEF1) (Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte, Hund, Rind (Kuh), Meerschweinchen, Pferd, Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GRF2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Sequenz: LWAKEQNEEK SPNLTQFTEH FNNMSYWVRS IIMLQEKAQD RERLLLKFIK

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rat: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against RAPGEF1. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Affinity Purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human RAPGEF1

Anwendungsinformationen

Applikationshinweise: Optimal working dilutions should be determined experimentally by the investigator.

Kommentare:

Antigen size: 1077 AA

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freeze-thaw cycles.

Lagerung: -20 °C

Informationen zur Lagerung: For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Details zu GRF2

Target: GRF2 (RAPGEF1) (Rap Guanine Nucleotide Exchange Factor (GEF) 1 (RAPGEF1))

Andere Bezeichnung: RAPGEF1 (RAPGEF1 Produkte)

Synonyme: C3G antikoerper, GRF2 antikoerper, Link-GEFII antikoerper, 4932418O06Rik antikoerper, Grf2 antikoerper, RAPGEF1 antikoerper, C3G-1 antikoerper, C3G-2 antikoerper, C3g antikoerper, rapgef1 antikoerper, zgc:56372 antikoerper, Rap guanine nucleotide exchange factor 1 antikoerper, Rap guanine nucleotide exchange factor like 1 antikoerper, Rap guanine nucleotide exchange factor (GEF) 1 antikoerper, Rap guanine nucleotide exchange factor 1 S homeolog antikoerper, Rap guanine nucleotide exchange factor (GEF) 1b antikoerper, RAPGEF1 antikoerper, RAPGEFL1 antikoerper, Rapgef1 antikoerper, rapgef1.S antikoerper, rapgef1 antikoerper, rapgef1b antikoerper, Rapgefl1 antikoerper

Hintergrund: RAPGEF1 is a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade protein may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation.This gene encodes a human guanine nucleotide exchange factor. It transduces signals from CRK by binding the SH3 domain of CRK, and activating several members of the Ras family of GTPases. This signaling cascade that may be involved in apoptosis, integrin-mediated signal transduction, and cell transformation. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some variants has not been determined.
Alias Symbols: C3G, DKFZp781P1719, GRF2
Protein Interaction Partner: UBC, MBIP, SLC20A1, ATXN1, RPS15, CRKL, CRK, CBL, GRB2, NEDD9, RHOQ, BCAR1, SHC1, RRAS2, HRAS, RAP1B, HCK, RAP1A,
Protein Size: 1077

Molekulargewicht: 120 kDa

Gen-ID: 2889

NCBI Accession: NM_005312, NP_005303

UniProt: Q13905

Pathways: Interferon-gamma Pathway, Neurotrophin Signalübertragung, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor