BAX Antikörper (AA 55-178)
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- Target Alle BAX Antikörper anzeigen
- BAX (BCL2-Associated X Protein (BAX))
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Bindungsspezifität
- AA 55-178
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser BAX Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP)
- Kreuzreaktivität
- Hund
- Produktmerkmale
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - Aufreinigung
- Purified from tissue culture supernatant or ascites by affinity chromatography.
- Immunogen
- Human Bax-alpha
- Klon
- 3
- Isotyp
- IgG1
- Top Product
- Discover our top product BAX Primärantikörper
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- Kommentare
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Related Products: ABIN968587, ABIN967389
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Konzentration
- 250 µg/ml
- Buffer
- Aqueous buffered solution containing BSA, glycerol.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- -20 °C
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p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop." in: Oncogene, Vol. 21, Issue 31, pp. 4715-27, (2002) (PubMed).
: "Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells." in: Oncogene, Vol. 20, Issue 36, pp. 4995-5004, (2001) (PubMed).
: "Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signalling." in: Oncogene, Vol. 19, Issue 39, pp. 4461-8, (2000) (PubMed).
: "Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast." in: Molecular cell, Vol. 1, Issue 3, pp. 337-46, (1998) (PubMed).
: "
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p53 induces the expression of its antagonist p73 Delta N, establishing an autoregulatory feedback loop." in: Oncogene, Vol. 21, Issue 31, pp. 4715-27, (2002) (PubMed).
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- Target
- BAX (BCL2-Associated X Protein (BAX))
- Andere Bezeichnung
- Bax (BAX Produkte)
- Synonyme
- BAX-ALPHA antikoerper, bax-A antikoerper, xBax antikoerper, xlbax antikoerper, BAX antikoerper, bax antikoerper, fj16e01 antikoerper, wu:fc50b10 antikoerper, wu:fj16e01 antikoerper, BCL2L4 antikoerper, zgc:112983 antikoerper, BCL2 associated X, apoptosis regulator antikoerper, BCL2-associated X protein L homeolog antikoerper, BCL2-associated X protein antikoerper, bcl2-associated X protein, a antikoerper, bcl2-associated X protein, b antikoerper, BAX antikoerper, bax.L antikoerper, bax antikoerper, baxa antikoerper, Bax antikoerper, baxb antikoerper
- Hintergrund
- Proper development and maintenance of homeostasis within tissues is achieved through cell proliferation, differentiation, and apoptosis. Members of the Bcl-2 protein family function to either inhibit (Bcl-2 and Bcl-XL) or promote (Bax and Bak) apoptosis. Similar to other family members, Bax contains the conserved Bcl-2 homology 1 (BH1) and 2 (BH2) domains which allow for its homodimerization or heterodimerization with Bcl-2. Although Bax alone does not induce cell death, elevated levels of Bax accelerate apoptosis following a death signal such as cytokine deprivation or Fas/Fas ligand interaction. The ratio of Bax homodimers to Bax/Bcl-2 heterodimers is an apoptotic checkpoint. When Bcl-2 is in excess, apoptosis is inhibited. However, if Bax levels increase in response to a death signal, the cell is pushed toward death. Bax function is also affected by Bax Inhibitor-1 (BI-1). Although it interacts directly with Bcl-2 and not Bax, BI-1 can suppress Bax-induced apoptosis. Alternative splicing of Bax mRNA produces Bax-alpha, the integral membrane form, and the two cytosolic forms beta and gamma. These isoforms are thought to allow for differential regulation of Bax activity and localization. This antibody is routinely tested by western blot analysis.
- Molekulargewicht
- 21 kDa
- Pathways
- p53 Signalweg, PI3K-Akt Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
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