Adrenergic, Beta, Receptor Kinase 1 (ADRBK1) Antikörper

Details zu Produkt Nr. ABIN966226, Anbieter: Anmelden zum Anzeigen
Antigen
  • Adrbk-1
  • Bark-1
  • GRK2
  • betaARK1
  • BARK1
  • BETA-ARK1
  • GRK-2
  • Grk2
  • beta-adrenergic receptor kinase 1
  • G protein-coupled receptor kinase 2
  • Tsp_00497
  • grk2
  • Grk2
  • GRK2
Reaktivität
Human, Maus, Ratte (Rattus), Affe
135
71
70
17
12
12
9
5
4
3
3
1
1
1
1
Wirt
Maus
93
25
16
2
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
4
4
4
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
117
72
52
25
17
11
4
3
1
1
1
Optionen
Hersteller
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Immunogen Purified recombinant fragment of human GRK2 expressed in E. Coli.
Klon 3F8
Isotyp IgG1
Reinigung Ascitic fluid
Andere Bezeichnung GRK2 (ADRBK1 Antibody Abstract)
Hintergrund The product of this gene phosphorylates the beta-2-adrenergic receptor and appears to mediate agonist-specific desensitization observed at high agonist concentrations. This protein is an ubiquitous cytosolic enzyme that specifically phosphorylates the activated form of the beta-adrenergic and related G-protein-coupled receptors. Abnormal coupling of betaadrenergic receptor to G protein is involved in the pathogenesis of the failing heart.
Tissue specificity: Expressed in peripheral blood leukocytes
Synonyms: GRK2, BARK1, FLJ16718, BETA-ARK1, ADRBK1
Molekulargewicht 80kDa
Gen-ID 156
Forschungsgebiet Signaling
Pathways EGFR Signaling Pathway, Neurotrophin Signalübertragung, Regulation of G-Protein Coupled Receptor Protein Signaling, CXCR4-mediated Signaling Events, G-protein mediated Events, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
Applikationshinweise Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Allgemeine Veröffentlichungen Sterne-Marr, Leahey, Bresee, Dickson, Ho, Ragusa, Donnelly, Amie, Krywy, Brookins-Danz, Orakwue, Carr, Yoshino-Koh, Li, Tesmer: "GRK2 activation by receptors: role of the kinase large lobe and carboxyl-terminal tail." in: Biochemistry, Vol. 48, Issue 20, pp. 4285-93, 2009 (PubMed).

Produkt verwendet in: Chen, Long, Wu, Jiang, Ma: "EGF transregulates opioid receptors through EGFR-mediated GRK2 phosphorylation and activation." in: Molecular biology of the cell, Vol. 19, Issue 7, pp. 2973-83, 2008 (PubMed).

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