RPS6KB2 Antikörper (Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2) (AA 452-482)

Details for Product anti-RPS6KB2 Antibody No. ABIN392546, Anbieter: Anmelden zum Anzeigen
Antigen
  • KLS
  • P70-beta
  • P70-beta-1
  • P70-beta-2
  • S6K-beta2
  • S6K2
  • SRK
  • STK14B
  • p70(S6K)-beta
  • p70S6Kb
  • 70kDa
  • ribosomal protein S6 kinase, 70kDa, polypeptide 2
  • ribosomal protein S6 kinase, polypeptide 2
  • RPS6KB2
  • Rps6kb2
Epitop
AA 452-482, C-Term
32
15
15
15
14
14
12
9
6
6
5
5
5
5
4
4
4
3
3
2
2
2
2
1
1
1
1
1
1
1
Reaktivität
Human
234
117
81
2
2
2
1
1
Wirt
Kaninchen
204
29
2
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser RPS6KB2 Antikörper ist unkonjugiert
16
16
15
7
7
7
4
4
4
4
4
4
4
4
4
4
4
2
Applikation
Western Blotting (WB)
167
98
54
35
34
26
12
9
3
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 452-482 AA from the C-terminal region of human p70 S6Kbeta.
Klon RB0891
Isotyp Ig
Spezifität This p70 S6Kbeta antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 453~482 amino acids from the C-terminal region of human p70 S6Kbeta.
Reinigung This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
Andere Bezeichnung p70 S6Kbeta (RPS6KB2 Antibody Abstract)
Hintergrund This gene encodes a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. This kinase contains 2 nonidentical kinase catalytic domains and phosphorylates the S6 ribosomal protein and eucaryotic translation initiation factor 4B. Phosphorylation of S6 leads to an increase in protein synthesis and cell proliferation.
Synonyms: Ribosomal protein S6 kinase beta 2, 70 kDa ribosomal protein S6 kinase 2, p70 ribosomal S6 kinase beta, S6 kinase-related kinase, Serine/threonine-protein kinase 14 beta, RPS6KB2, STK14B
Molekulargewicht 53483 DA
Gen-ID 6199
UniProt Q9UBS0
Forschungsgebiet Translation Factors, Phospho-specific antibodies, Protein Modifications, Cell Cycle, Signaling, Cell Structure
Pathways PI3K-Akt Signalweg, RTK Signalweg, AMPK Signaling, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
Applikationshinweise WB = 1:1000
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 2 mg/mL
Buffer PBS with 0.09 % (W/V) sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
Haltbarkeit 6 months
Bilder des Herstellers
Western Blotting (WB) image for anti-Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 2 (RPS6KB2) (AA 452-482), (C-Term) antibody (ABIN392546) Western blot analysis of anti-p70S6Kbeta Pab (ABIN392546) in A375 cell lysate. p70S6K...
Produkt verwendet in: Kroczynska, Mehrotra, Majchrzak-Kita, Arslan, Altman, Stein, McMahon, Kozlowski, Kahle, Eklund, Fish, Platanias: "Regulatory effects of SKAR in interferon ? signaling and its role in the generation of type I IFN responses." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 31, pp. 11377-82, 2014 (PubMed).

Cruz, Hedden, Boyer, Kharas, Fruman, Lee-Fruman: "S6 kinase 2 potentiates interleukin-3-driven cell proliferation." in: Journal of leukocyte biology, Vol. 78, Issue 6, pp. 1378-85, 2005 (PubMed).

Allgemeine Veröffentlichungen Strausberg, Feingold, Grouse, Derge, Klausner, Collins, Wagner, Shenmen, Schuler, Altschul, Zeeberg, Buetow, Schaefer, Bhat, Hopkins, Jordan, Moore, Max, Wang, Hsieh, Diatchenko, Marusina, Farmer et al.: "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. ..." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 26, pp. 16899-903, 2002 (PubMed).

Lee-Fruman, Kuo, Lippincott, Terada, Blenis: "Characterization of S6K2, a novel kinase homologous to S6K1." in: Oncogene, Vol. 18, Issue 36, pp. 5108-14, 1999 (PubMed).

Saitoh, ten Dijke, Miyazono, Ichijo: "Cloning and characterization of p70(S6K beta) defines a novel family of p70 S6 kinases." in: Biochemical and biophysical research communications, Vol. 253, Issue 2, pp. 470-6, 1999 (PubMed).

Gout, Minami, Hara, Tsujishita, Filonenko, Waterfield, Yonezawa: "Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region." in: The Journal of biological chemistry, Vol. 273, Issue 46, pp. 30061-4, 1998 (PubMed).

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