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anti-Rat (Rattus) TNFSF9 Antikörper:
anti-Mouse (Murine) TNFSF9 Antikörper:
anti-Human TNFSF9 Antikörper:
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Human Monoclonal TNFSF9 Primary Antibody für FACS - ABIN2688965
Chu, DeBenedette, Stiernholm, Barber, Watts: Role of IL-12 and 4-1BB ligand in cytokine production by CD28+ and CD28- T cells. in Journal of immunology (Baltimore, Md. : 1950) 1997
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Mouse (Murine) Monoclonal TNFSF9 Primary Antibody für BR, FACS - ABIN2688839
Akiba, Miyahira, Atsuta, Takeda, Nohara, Futagawa, Matsuda, Aoki, Yagita, Okumura: Critical contribution of OX40 ligand to T helper cell type 2 differentiation in experimental leishmaniasis. in The Journal of experimental medicine 2000
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Human Monoclonal TNFSF9 Primary Antibody für ELISA, FACS - ABIN610414
Hutton, Christofori, Chi, Edman, Guest, Hanahan, Kelly: Molecular cloning of mouse pancreatic islet R-cadherin: differential expression in endocrine and exocrine tissue. in Molecular endocrinology (Baltimore, Md.) 1994
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Human Monoclonal TNFSF9 Primary Antibody für ICC, FACS - ABIN1169256
Gullo, Koh, Pang, Ho, Tan, Schwarz: Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling. in PLoS ONE 2010
Human Polyclonal TNFSF9 Primary Antibody für CyTOF, FACS - ABIN4900479
Ek, Björck, Högerkorp, Nordenskjöld, Porwit-MacDonald, Borrebaeck: Mantle cell lymphomas acquire increased expression of CCL4, CCL5 and 4-1BB-L implicated in cell survival. in International journal of cancer 2006
the role of CD137 (zeige TNFRSF9 Antikörper)-CRDI (cysteine rich domain I) in the binding of CD137 (zeige TNFRSF9 Antikörper)-CD137L was further investigated.
Data indicate that anti-CD137 (zeige TNFRSF9 Antikörper) agonists can function as inhibitors of CD137L signaling, resulting in the creation of tumor microenvironments unfavorable for tumor immune evasion.
Constitutive interaction between 4-1BB (zeige TNFRSF9 Antikörper) and 4-1BBL on murine LPS (zeige TLR4 Antikörper)-activated bone marrow dendritic cells masks detection of 4-1BBL by TKS (zeige PTK6 Antikörper)-1 but not 19H3 antibody.
4-1BBL can restrain effector T cell development, creating a more favorable regulatory T cell to effector cell balance under tolerogenic conditions, and this may be particularly active in mucosal barrier tissues
These results demonstrate that 4-1BBL-engineered DCs can improve CIKs (zeige TRAF3IP2 Antikörper) cytotoxicity against prostate cancer cells.
these observations suggest that inhibition of the TLR/4 (zeige TLR4 Antikörper)-1BBL complex formation may be highly efficient in protecting against continued inflammation
4-1BB (zeige TNFRSF9 Antikörper) mediates the inflammatory responses in obese skeletal muscle by interacting with its ligand 4-1BBL on macrophages.
CD137 (zeige TNFRSF9 Antikörper)-CD137L interactions mediated via regulation of CyPA (zeige PPIA Antikörper) contribute to the progression of atherosclerosis.
Data indicate that CD137L deficient mice displayed a variety of immunological dysfunctions.
monocytes interact with iNKT cells to increase expression of 4-1BBL and 4-1BB (zeige TNFRSF9 Antikörper), and in conjunction with this pathway, maintain their numbers at baseline.
blocking of both OX-40L (zeige TNFSF4 Antikörper) and 4-1BBL reversed radiation-enhanced T-cell killing of human tumor targets as well as T-cell survival and activation.
CD137L is overexpressed in non-small cell lung cancer specimens and positive expression of CD137L was associated with better overall survival.
In vitro immunotherapy is described for anti-prostate cancer effects of cytotoxic T lymphocytes induction by recombinant adenovirus mediated PSMA/4 (zeige PSMA4 Antikörper)-1BBL dendritic cells.
vaccination with recombinant attenuated Salmonella harboring the CEACAM6 and 4-1BBL gene efficiently increased the number of CD3 (zeige CD3 Antikörper)+CD8 (zeige CD8A Antikörper)+ TIL (zeige TLR1 Antikörper) and NK cells, decreased the number of FOXP3 (zeige FOXP3 Antikörper) cells and inhibited the development of DMH (zeige DST Antikörper)-induced colorectal cancer
Elevated plasma levels and monocyte-associated expression of CD137 (zeige TNFRSF9 Antikörper) ligand in patients with acute atherothrombotic stroke
Hence, the targeted combination of IL-15 (zeige IL15 Antikörper) and 4-BBL (zeige TP53 Antikörper) in the form of a trifunctional antibody-fusion protein is a promising new approach for cancer immunotherapy.
TIRAP (zeige TIRAP Antikörper) and IRAK2 (zeige IRAK2 Antikörper) are critical for the sustained inflammatory response that is mediated by late-phase signaling by the TLR-4 (zeige TLR4 Antikörper)-1BBL complex.
this is the first study to indicate that this member of the TNF (zeige TNF Antikörper) superfamily, CD137 (zeige TNFRSF9 Antikörper), is modulated by SAHA treatment in breast
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
, tumor necrosis factor (ligand) superfamily, member 9
, 4-1BB ligand
, tumor necrosis factor ligand superfamily member 9
, homolog of mouse 4-1BB-L
, receptor 4-1BB ligand