TNFSF9 Antikörper

Produktnummer ABIN6940973

Dieser Maus Monoklonal Antikörper detektiert spezifisch TNFSF9 in FACS, IHC und IF. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für TNFSF9 Antikörper (ABIN6940973)

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFSF9 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunofluorescence (IF)

Klon: CD137L-1547

Produktdetails anti-TNFSF9 Antikörper

Verwendungszweck: CD137L / 4-1BBL / TNFSF9 Antibody

Spezifität: TNFSF9 / 4-1BBL is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9 / 4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9 / 4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. It has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine is required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant full-length human CD137L protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Positive Control: Raji, 293T, HEK293 cells. Kidney.

Known Application: Flow Cytometry (1-2 μg/million cells in 0.1ml), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu TNFSF9

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Andere Bezeichnung: TNFSF9

Hintergrund:

4-1BB ligand, 4-1BBL, CD137L, ILA ligand (TNF related), Ly63l, Tumor necrosis factor ligand 5A (TNLG5A), Tumor necrosis factor ligand superfamily member 9 (TNFSF9)

Raji

Molekulargewicht: 27kDa

Gen-ID: 8744, 1524

UniProt: P41273

Pathways: Activated T Cell Proliferation, Cancer Immune Checkpoints