TNFSF9 Antikörper (Extracellular Domain)

Produktnummer ABIN1169256

Produktdetails anti-TNFSF9 Antikörper

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Bindungsspezifität: Extracellular Domain

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TNFSF9 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Spezifität: Recognizes extracellular domain of human CD137L.

Kreuzreaktivität: Human

Keine Kreuzreaktivität: Maus

Kreuzreaktivität (Details): Does not cross-react with mouse CD137L.

Sterilität: 0.2 μm filtered

Immunogen: Recombinant human CD137L extracellular domain.

Klon: 41B436

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-TNFSF9 Antikörper (ABIN1169256)

Gullo, Koh, Pang, Ho, Tan, Schwarz: "Inhibition of proliferation and induction of apoptosis in multiple myeloma cell lines by CD137 ligand signaling." in: PLoS ONE, Vol. 5, Issue 5, pp. e10845, (2010) (PubMed).

Details zu TNFSF9

Target: TNFSF9 (Tumor Necrosis Factor (Ligand) Superfamily, Member 9 (TNFSF9))

Andere Bezeichnung: CD137L (TNFSF9 Produkte)

Synonyme: TNFSF9 antikoerper, 4-1BB-L antikoerper, 4-1BBL antikoerper, AI848817 antikoerper, Cd137l antikoerper, Ly63l antikoerper, CD137L antikoerper, TNF superfamily member 9 antikoerper, tumor necrosis factor (ligand) superfamily, member 9 antikoerper, Tnfsf9 antikoerper, LOC476729 antikoerper, TNFSF9 antikoerper

Hintergrund: The CD137 ligand (CD137L, 4-1BBL) is a member of the tumor necrosis factor (TNF) family. CD137L is a type II, transmembrane protein found on activated macrophages, dendritic cells and mature B cells. The interaction with its receptor 4-1BB induces recruitment of TNF receptor-associated factor 1 (TRAF1) and TRAF2 and interaction with the kinase p56lck. CD137 and CD137L have been reported to be involved in tumor rejection, apoptosis, anti-viral immunity, diabetes, in T and B cell co-stimulation and modulation of the immune response.

UniProt: P41273

Pathways: Activated T Cell Proliferation, Cancer Immune Checkpoints