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UVRAG complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. Zusätzlich bieten wir Ihnen UVRAG Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal UVRAG Primary Antibody für IF, IHC (p) - ABIN388586
Liang, Feng, Ku, Dotan, Canaani, Oh, Jung: Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. in Nature cell biology 2006
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Human Polyclonal UVRAG Primary Antibody für WB - ABIN1882151
Vogt, Affara, Davey, Hammer, Jobling, Lau, Mitchell, Schempp, Tyler-Smith, Williams, Yen, Rappold: Report of the Third International Workshop on Y Chromosome Mapping 1997. Heidelberg, Germany, April 13-16, 1997. in Cytogenetics and cell genetics 1998
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Human Polyclonal UVRAG Primary Antibody für ICC, IF - ABIN438721
Sun, Li, Zhang, Chen, Zhang, Li, Deng, Qian, Jiao, Ji, Li, Wu, Yu, Feng, Zhu: Acetylation of Beclin 1 inhibits autophagosome maturation and promotes tumour growth. in Nature communications 2015
UVRAG is a regulator of CRL4(DDB2 (zeige DDB2 Antikörper))-mediated nucleotide excision repair and its expression levels may influence melanoma predisposition.
Under-expression of UVRAG is associated with colorectal cancer.
UVRAG frameshift is expressed as a truncated protein in colorectal cancer with microsatellite instability and promotes tumorigenesis. UVRAG(FS) expression renders cells more sensitive to standard chemotherapy regimen due to a DNA repair defect.
HCV, by differentially inducing the expression of Rubicon (zeige KIAA0226 Antikörper) and UVRAG, temporally regulated the autophagic flux to enhance its replication.
tubulation requires mTOR (zeige FRAP1 Antikörper) activity, and we identified two direct mTOR (zeige FRAP1 Antikörper) phosphorylation sites on UVRAG (S550 and S571) that activate VPS34 (zeige PIK3C3 Antikörper).
Beclin 1 (zeige BECN1 Antikörper) and UVRAG confer protection against radiation-induced DNA DNA double strand breaks and may maintain centrosome stability in established tumor cells.
Dephosphorylation of UVRAG facilitates the lysosomal degradation of epidermal growth factor receptor (EGFR (zeige EGFR Antikörper)), reduces EGFR (zeige EGFR Antikörper) signaling, and suppresses cancer cell proliferation and tumor growth.
The reports that Grb2 (zeige GRB2 Antikörper), when in excess (zeige RCC1 Antikörper), interacts with ultraviolet radiation resistance-associated gene protein (UVRAG) under excess conditions of AICD-Grb2 (zeige GRB2 Antikörper) or Grb2 (zeige GRB2 Antikörper).
UVRAG is required for virus entry through combinatorial interaction with the class C-Vps complex and SNAREs.
Akt1 (zeige AKT1 Antikörper) may inhibit autophagy by decreasing UVRAG expression, which also sensitizes cancer cells to UV irradiation.
Beclin 1 (zeige BECN1 Antikörper) regulates endosome pathways via the UVRAG-VPS34 (zeige PIK3C3 Antikörper) complex.
EWSR1 (zeige EWSR1 Antikörper) is involved in the post-transcriptional regulation of Uvrag via a miRNA-dependent pathway, resulting in the deregulation of autophagy inhibition.
silencing of UVRAG significantly attenuated the antimicrobial effects of macrophages against M. tuberculosis.
data provide novel insights into the control of autophagy in T cells and identify UVRAG as a new regulator of naive peripheral T-cell homeostasis.
in Escherichia coli-containing phagosomes of mouse macrophages, Slamf1 (zeige SLAMF1 Antikörper) interacts with the class III PI3K Vps34 (zeige PIK3C3 Antikörper) in a complex with Beclin-1 (zeige BECN1 Antikörper) and UVRAG
UVRAG has cytoprotective functions in the cytosol that control the localization of Bax (zeige BAX Antikörper) in tumor cells exposed to apoptotic stimuli
through ultraviolet irradiation resistance-associated gene (UVRAG), Bif-1 (zeige SH3GLB1 Antikörper) interacts with Beclin 1 (zeige BECN1 Antikörper) and functions as a positive mediator of the class III PI(3 (zeige PI3 Antikörper)) kinase (PI(3 (zeige PI3 Antikörper))KC3).
These results suggest that mammalian cells have at least two distinct class III PI3-kinase (zeige PIK3CA Antikörper) complexes, and that beclin 1 (zeige BECN1 Antikörper) interacts distinctly with mammalian Atg14 and UVRAG in two of these complexes.
The UVRAG-containing PI3K (III) complex is required for receptor downregulation through endolysosomal degradation and for the establishment of proper cell polarity in the developing wing.
UVRAG-mutated heterotaxy patient cells also display highly increased Notch (zeige NOTCH1 Antikörper) protein levels
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
UV radiation resistance-associated gene protein
, beclin 1 binding protein
, disrupted in heterotaxy
, UV radiation resistance associated
, UV radiation resistance associated gene
, UV radiation resistance-associated gene protein-like