anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Antikörper

UPF2 encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
UPF2 26019 Q9HAU5
UPF2 326622  
UPF2 361271  
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Top anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) Antikörper auf antikoerper-online.de

Showing 10 out of 44 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-UPF2 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:62500 Positive Control: HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert FACS, WB UPF2 Antibody (Center)  western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the UPF2  antibody detected the UPF2  protein (arrow). UPF2 Antibody (Center)  flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, FACS, WB UPF2 Antibody (Center) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram). FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. UPF2 Antibody (Center) western blot analysis in MCF-7 cell line lysates (35 µg/lane). This demonstrates the UPF2 antibody detected the UPF2 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert ICC, IF, WB   0.1 mL Anmelden zum Anzeigen 8 bis 11 Tage
$514.63
Details
Pferd Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of Rent2 staining in rat kidney formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the an Western blot analysis of Rent2 expression in Jurkat (A), HepG2 (B), Hela (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert WB Western Blot: UPF2 Antibody [NBP1-80460] - HepG2 cell lysate, concentration 0.2-1 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Fledermaus Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$507.83
Details
k.A. Ziege Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$242.88
Details
Human Ziege Unkonjugiert ELISA   0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$446.88
Details

UPF2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) Antikörper

  1. Human Polyclonal UPF2 Primary Antibody für ICC, IF - ABIN4364426 : Nickless, Jackson, Marasa, Nugent, Mercer, Piwnica-Worms, You: Intracellular calcium regulates nonsense-mediated mRNA decay. in Nature medicine 2014 (PubMed)

Weitere Antikörper gegen UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) Interaktionspartner

Human UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Interaktionspartner

  1. we find that the interaction of UPF2 with UPF3b interferes with the assembly of the UPF2-eRF3 complex, and that UPF2 binds UPF3b more strongly than eRF3

  2. UPF2 binds the FRB domain of SMG1 (zeige SMG1 Antikörper), a region that regulates the related mTOR (zeige FRAP1 Antikörper) kinase.

  3. This study demonstrated the quantitative regulation of Upf1 (zeige UPF1 Antikörper) and Upf2 proteins by ubiquitin-proteasome system and SMG1 (zeige SMG1 Antikörper).

  4. UPF2 MIF4G-1 and MIF4G-2 domains appear to have a crucial scaffolding role, while the MIF4G-3 domain is the key module required for triggering nonsense-mediated decay.

  5. Data show that upon binding to Upf2, the regulatory CH domain of Upf1 (zeige UPF1 Antikörper) undergoes a large conformational change, causing the catalytic helicase domain to bind RNA less extensively and triggering its helicase activity.

  6. The authors propose that the bipartite mode of UPF2 binding to UPF1 (zeige UPF1 Antikörper) brings the ribosome and the exon junction complex in close proximity by forming a tight complex after an initial weak encounter with either element.

  7. The complex between the interacting domains of human UPF2 and UPF3b (zeige UPF3B Antikörper) at a 1.95 A resolution.

  8. During nonsense-mediated mRNA decay, CBP80 (zeige NCBP1 Antikörper) interacts with Upf1 (zeige UPF1 Antikörper) and promotes the interaction of Upf1 (zeige UPF1 Antikörper) with Upf2 but not with Stau1 (zeige STAU1 Antikörper).

  9. UPF2-silenced HeLa cells were impaired in their ability to recognize ectopically expressed aberrant premature termination codon transcripts

  10. UPF2 and UPF3b (zeige UPF3B Antikörper) cooperatively stimulate both ATPase (zeige DNAH8 Antikörper) and RNA helicase (zeige DDX46 Antikörper) activities of UPF1 (zeige UPF1 Antikörper).

Mouse (Murine) UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Interaktionspartner

  1. Upon removal of TDRD6, the association of several mRNAs with UPF1 and UPF2 is disturbed, and the long 3' UTR-stimulated but not the downstream exon-exon junction triggered pathway of NMD is impaired.This function depends on TDRD6-promoted assembly of mRNA and decay enzymes in Chromatoid bodies .

  2. we report that UPF2-mediated nonsense-mediated mRNA decay (NMD) plays an essential role in male germ cells by eliminating ubiquitous genes-derived, longer 3'UTR (zeige UTS2R Antikörper) transcripts, and that this role is independent of its canonical role in degrading "premature termination codon" (PTC (zeige PTCH1 Antikörper))-containing transcripts in somatic cell lineages

  3. UPF2, a nonsense-mediated mRNA decay factor, is required for prepubertal Sertoli cell development and male fertility by ensuring fidelity of the transcriptome.

  4. Study find that loss of Upf2 during fetal liver development is incompatible with postnatal life due to failure of terminal differentiation. Moreover, deletion of Upf2 in the adult liver results in hepatosteatosis and disruption of liver homeostasis.

  5. Hematopoietic-specific deletion of Upf2, a core NMD factor, led to the rapid, complete, and lasting cell-autonomous extinction of all hematopoietic stem and progenitor populations.

UPF2 Regulator of Nonsense Transcripts Homolog (Yeast) (UPF2) Antigen-Profil

Protein Überblick

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene\\\\; both variants encode the same protein.

Genbezeichner und Symbole assoziert mit UPF2

  • UPF2, regulator of nonsense mediated mRNA decay (UPF2) Antikörper
  • UPF2 regulator of nonsense transcripts homolog (yeast) (Upf2) Antikörper
  • UPF2, regulator of nonsense mediated mRNA decay (Upf2) Antikörper
  • UPF2 regulator of nonsense transcripts homolog (yeast) (UPF2) Antikörper
  • UPF2 regulator of nonsense transcripts homolog (yeast) (upf2) Antikörper
  • HUPF2 Antikörper
  • RENT2 Antikörper
  • smg-3 Antikörper

Bezeichner auf Proteinebene für UPF2

nonsense mRNA reducing factor 2 , regulator of nonsense transcripts 2 , smg-3 homolog, nonsense mediated mRNA decay factor , up-frameshift suppressor 2 homolog , yeast Upf2p homolog , UPF2 regulator of nonsense transcripts homolog (yeast)

GENE ID SPEZIES
26019 Homo sapiens
326622 Mus musculus
361271 Rattus norvegicus
419100 Gallus gallus
450304 Pan troglodytes
487130 Canis lupus familiaris
569006 Danio rerio
781181 Bos taurus
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