anti-Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Antikörper

SCN9A encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Zusätzlich bieten wir Ihnen SCN9A Kits (11) und SCN9A Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SCN9A 20274  
SCN9A 78956 O08562
SCN9A 6335 Q15858
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Top anti-SCN9A Antikörper auf antikoerper-online.de

Showing 10 out of 97 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Hamster Maus Unkonjugiert AA, ICC, IF, IP, WB Nav1.7 (S68-6) in T-CHO Nav1.7 (S68-6), Mouse brain tissue, Amplifier 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
411,87 €
Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue, using SCN9A Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
342,86 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of Nav1.7 expression in MCF7 (A), NIH3T3 (B), H9C2 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
Details
Human Maus Unkonjugiert ICC, IF, IHC, IHC (fro), IHC (p), IP, WB Immunohistochemistry-Frozen: Nav1.7 Antibody (S68-6) [NBP2-12904] - Tissue: Brain Slice. Species: Mouse. Fixation: Frozen sections. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody at 1:1000. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown). Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain. Western Blot: Nav1.7 Antibody (S68-6) [NBP2-12904] - analysis of hamster CHO cells showing detection of Nav1.7 Sodium Channel protein using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Load: 15 ug protein. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
381,00 €
Details
Human Maus Unkonjugiert ICC, IHC, IP, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
653,02 €
Details
Hamster Maus HRP AA, ICC, IF, IP, WB Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Tissue: Brain Slice. Species: Mouse. Fixation: Frozen sections. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown). Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain. Western Blot analysis of hamster CHO cells showing detection of Nav1.7 Sodium Channel protein using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
453,77 €
Details
Human Kaninchen Unkonjugiert IHC (p) 50 μg Anmelden zum Anzeigen 8 bis 10 Tage
456,00 €
Details
Hamster Maus FITC AA, ICC, IF, IP, WB Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Tissue: Brain Slice. Species: Mouse. Fixation: Frozen sections. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown). Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain. Western Blot analysis of hamster CHO cells showing detection of Nav1.7 Sodium Channel protein using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
458,56 €
Details
Hamster Maus Alkaline Phosphatase (AP) AA, ICC, IF, IP, WB Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Tissue: Brain Slice. Species: Mouse. Fixation: Frozen sections. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown). Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain. Western Blot analysis of hamster CHO cells showing detection of Nav1.7 Sodium Channel protein using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
460,95 €
Details
Hamster Maus Biotin AA, ICC, IF, IP, WB Immunohistochemistry analysis using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Tissue: Brain Slice. Species: Mouse. Fixation: Frozen sections. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000. Secondary Antibody: HRP/DAB Detection System: Biotinylated Goat Anti-Mouse, Streptavidin Peroxidase, DAB Chromogen (brown). Counterstain: Mayer Hematoxylin (purple/blue) nuclear stain. Western Blot analysis of hamster CHO cells showing detection of Nav1.7 Sodium Channel protein using Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody, Clone S68-6 . Load: 15 µg. Block: 1.5% BSA for 30 minutes at RT. Primary Antibody: Mouse Anti-Nav1.7 Sodium Channel Monoclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Sheep Anti-Mouse IgG: HRP for 1 hour at RT. 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
463,34 €
Details

SCN9A Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-SCN9A Antikörper

  1. Hamster Monoclonal SCN9A Primary Antibody für AA, ICC - ABIN361773 : Dray: Neuropathic pain: emerging treatments. in British journal of anaesthesia 2008 (PubMed)
    Zeige alle 4 Referenzen für 361773

  2. Human Polyclonal SCN9A Primary Antibody für IHC, ELISA - ABIN1535378 : Cox, Reimann, Nicholas, Thornton, Roberts, Springell, Karbani, Jafri, Mannan, Raashid, Al-Gazali, Hamamy, Valente, Gorman, Williams, McHale, Wood, Gribble, Woods: An SCN9A channelopathy causes congenital inability to experience pain. in Nature 2006 (PubMed)

Weitere Antikörper gegen SCN9A Interaktionspartner

Cow (Bovine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. TNF-alpha (zeige TNF Antikörper) up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha (zeige TNF Antikörper)

  2. Findings suggest that the endothelin-1 (zeige EDN1 Antikörper)-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau.

  3. Nav1.7-Ca2 (zeige CA2 Antikörper)+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK (zeige MAPK1 Antikörper)) and p38 (zeige MAPK14 Antikörper) attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK (zeige MAPK1 Antikörper) and p38 (zeige MAPK14 Antikörper)

  4. constitutively phosphorylated/activated ERK (zeige MAPK1 Antikörper) destabilizes Na(+) channel alpha-subunit (zeige POLG Antikörper) mRNA via translational event, which negatively regulates steady-state level of alpha-subunit (zeige POLG Antikörper) mRNA and cell surface expression of functional Na(+) channels.

  5. Na influx via scn9a converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. the FGF13 (zeige FGF13 Antikörper)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  2. this paper shows that Nav1.7, by coupling with CRMP1 (zeige CRMP1 Antikörper), mediates the axonal retrograde signaling of Sema3A (zeige SEMA3A Antikörper) in axonal guidance

  3. Experiments show that integration of synaptic inputs over time by Nav1.7 is critical for body weight regulation and reveal a mechanism for synaptic control of circuits regulating long term homeostatic functions.

  4. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (zeige PENK Antikörper) mRNA and met-enkephalin protein in sensory neurons.

  5. Global Nav1.7 knockouts showed no defects in mechanical sensitivity or overall movement yet were completely insensitive to painful tactile, thermal, and chemical stimuli and were anosmic.

  6. Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability.

  7. a novel regulatory mechanism that utilizes CRMP2 (zeige DPYSL2 Antikörper) SUMOylation to choreograph NaV1.7 trafficking.

  8. Behavioural deficits in Nav1.7/Nav1.8 (zeige SCN10A Antikörper) knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  9. Deleting SCN9A in both sensory and sympathetic neurons abolishes pain sensations.

  10. These results demonstrate increased expression levels of Nav1.7, Nav1.8 (zeige SCN10A Antikörper), and perhaps Nav1.1 (zeige SCN1A Antikörper) in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (zeige NF1 Antikörper) gene

Human Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. the FGF13 (zeige FGF13 Antikörper)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  2. This study showed that gain-of-function attributes at the channel level and differential effects of physiologically relevant thermal stimuli on the excitability of DRG neurons expressing mutant and WT Nav1.7 channels, suggesting a cellular mechanism for warmth-triggered pain episodes in Erythromelalgia patients.

  3. The four congenital insensitivity to pain families, while not closely related, belong to the same ethnic group and clan (zeige NLRC4 Antikörper), and the SCN9A mutation may be specific, if not unique to this group

  4. A novel Nav1.9 (zeige SCN11A Antikörper) mutation, p.Arg222His, was identified in patients with early-onset pain in distal extremities including joints and gastrointestinal disturbances, but was absent from an asymptomatic blood relative.

  5. Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

  6. Results indicate that Nav 1.7 promotes gastric cancer progression through MACC1 (zeige MACC1 Antikörper)-mediated upregulation of NHE1 (zeige SLC9A1 Antikörper).

  7. report the engineering of highly potent and selective inhibitors of the Nav1.7 channel based on tarantula ceratotoxin-1 (CcoTx1). We utilized a combination of directed evolution, saturation mutagenesis, chemical modification, and rational drug design to obtain higher potency and selectivity to the Nav1.7 channel

  8. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of human NaV1.7.

  9. Postoperative pain was affected by SCN9A genetic variability in gynecological surgical patients.

  10. Patients with the SCN9A mutation with inherited erythromelalgia were characterized for the pain phenotype among individuals.

SCN9A Antigen-Profil

Protein Überblick

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.

Genbezeichner und Symbole assoziert mit SCN9A

  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A) Antikörper
  • sodium channel, voltage-gated, type IX, alpha (Scn9a) Antikörper
  • DKFZp459G084 Antikörper
  • ETHA Antikörper
  • FEB3B Antikörper
  • GEFSP7 Antikörper
  • mKIAA4197 Antikörper
  • Nav1.7 Antikörper
  • NE-NA Antikörper
  • NENA Antikörper
  • PN1 Antikörper
  • Scn2a Antikörper
  • SCN9A Antikörper
  • SFNP Antikörper

Bezeichner auf Proteinebene für SCN9A

sodium channel, voltage-gated, type IX, alpha subunit , sodium channel protein type 9 subunit alpha-like , peripheral sodium channel 1 , sodium channel 25 , sodium channel protein type 9 subunit alpha , sodium channel protein type IX subunit alpha , sodium channel, voltage-gated, type IX, alpha polypeptide , voltage-gated sodium channel alpha subunit Nav1.7 , voltage-gated sodium channel subunit alpha Nav1.7 , sodium channel, voltage-gated, type 9, alpha polypeptide , hNE-Na , neuroendocrine sodium channel , nas , schwann cell sodium channel , sodium channel alpha-subunit

GENE ID SPEZIES
488381 Canis lupus familiaris
533065 Bos taurus
100016648 Monodelphis domestica
100172961 Pongo abelii
100385702 Callithrix jacchus
100482886 Ailuropoda melanoleuca
100516701 Sus scrofa
100583836 Nomascus leucogenys
20274 Mus musculus
78956 Rattus norvegicus
6335 Homo sapiens
100009210 Oryctolagus cuniculus
Ausgewählte Anbieter für anti-SCN9A (SCN9A) Antikörper
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