Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) ELISA Kits

The precise function of PARK2 is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Zusätzlich bieten wir Ihnen PARK2 Antikörper (179) und PARK2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
PARK2 5071 O60260
PARK2 56816 Q9JK66
PARK2 50873 Q9WVS6
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Top PARK2 ELISA Kits auf antikoerper-online.de

Showing 5 out of 19 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Human 0.053 ng/mL 0.15 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 13 bis 16 Tage
$648.42
Details
Maus 0.78 pg/mL 3.12-200 pg/mL Typical standard curve 96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$910.56
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Human 0.053 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Anmelden zum Anzeigen 8 bis 12 Tage
$840.25
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Human
  96 Tests Anmelden zum Anzeigen 11 Days
$848.18
Details
Ratte
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$875.60
Details

Weitere ELISA Kits für PARK2 Interaktionspartner

Fruit Fly (Drosophila melanogaster) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Drosophila CHIP protects against mitochondrial dysfunction by acting downstream of Pink1 in parallel with Parkin

  2. Maintenance of tissue homeostasis upon reduction of Pink1 or Parkin appears to result from reduction of age- and stress-induced intestinal stem cell proliferation, in part, through induction of ISC senescence.

  3. activation of endoplasmic reticulum stress by defective mitochondria is neurotoxic in pink1 and parkin flies and that the reduction of this signalling is neuroprotective, independently of defective mitochondria.

  4. Pharmacological or genetic activation of heat shock protein 70 (Hsp70) protects against loss of parkin Function. Heat shock protein members may act as compensatory factors for parkin loss of function and that the exploitation of these factors may be of potential therapeutic value.

  5. autophosphorylation of PINK1 is essential for the mitochondrial translocation of Parkin and for subsequent phosphorylation and activation of Parkin.

  6. Our data indicate that PINK1 and Parkin play an important role in FUS (zeige FUS ELISA Kits)-induced neurodegeneration. This study has uncovered a previously unknown link between FUS (zeige FUS ELISA Kits) proteinopathy and PINK1/Parkin genes, providing new insights into the pathogenesis of FUS (zeige FUS ELISA Kits) proteinopathy.

  7. Clu (zeige CLU ELISA Kits) is upstream of and binds to VCP (zeige vcp ELISA Kits) in vivo and promotes VCP (zeige vcp ELISA Kits)-dependent Marf (zeige MFN2 ELISA Kits) degradation in vitro Marf (zeige MFN2 ELISA Kits) accumulates in whole muscle lysates of clu (zeige CLU ELISA Kits)-deficient flies and is destabilized upon Clu (zeige CLU ELISA Kits) overexpression. Thus, Clu (zeige CLU ELISA Kits) is essential for mitochondrial homeostasis and functions in concert with Parkin and VCP (zeige vcp ELISA Kits) for Marf (zeige MFN2 ELISA Kits) degradation to promote damaged mitochondrial clearance.

  8. Buffy has a role enhancing the loss of parkin and suppressing the loss of Pink1 phenotypes in Drosophila

  9. Parkin-dependent mitophagy suppresses neural neurodegeneration by removing damaged mitochondria.

  10. We demonstrate here that vps35 (zeige vps35 ELISA Kits) genetically interacts with parkin

Human Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Findings suggest that PARK2 might have a tumor suppressor role in the development of chronic obstructive pulmonary disease (COPD (zeige ARCN1 ELISA Kits)) and lung cancer.

  2. Here we review the evidence supporting PINK1/Parkin mitophagy in vivo and its causative role in neurodegeneration, and outline outstanding questions for future investigations.

  3. Although PARK2 may be a pathological factor for neurodevelopmental disorders , likely not all variants are pathogenic, and a conclusive assessment of PARK2 variant pathogenicity requires an accurate analysis of their location within the coding region and encoded functional domains.

  4. VPS35 (zeige vps35 ELISA Kits) regulates parkin substrate AIMP2 (zeige AIMP2 ELISA Kits) toxicity by facilitating lysosomal clearance of AIMP2 (zeige AIMP2 ELISA Kits).

  5. Results show that HERC5 mediates covalent ISG15 (zeige ISG15 ELISA Kits) conjugation to parkin in mammalian cells and that ISG15 (zeige ISG15 ELISA Kits) is conjugated to the Lys349 and Lys369 residues of parkin. This ISGylation increases the ubiquitin E3 ligase activity of parkin. Also, some familial Parkinson's disease-associated missense mutations of parkin display defective ISGylation.

  6. an impaired PINK1-PARK2-mediated neuroimmunology pathway contributes to septic death.

  7. This work provided strong new evidence that PARK2 participates to the regulatory networks associated with oxidative phosphorylation and suggested that PARK2 genetic variations could act as a trans regulator of OXPHOS gene macrophage expression in humans.

  8. REVIEW: role of parkin in modulating excitatory and dopaminergic synapse functions

  9. The effects of variants in the Parkin, PINK1, and DJ-1 (zeige PARK7 ELISA Kits) genes along with evidence for their pathogenicity have been summarized. (Review)

  10. Parkin is a potential link between melanoma and Parkinson's disease

Zebrafish Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Melatonin, added together with MPTP or added once MPTP was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin/PINK1/DJ-1/MUL1 loop and also the normal motor activity of the embryos.

Pig (Porcine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Single nucleotide polymorphism (SNP) analysis revealed seven SNPs in the porcine PARK2 gene, one missense and one silent mutation in exon 7 and five SNPs in intron 7

Mouse (Murine) Parkinson Protein 2, E3 Ubiquitin Protein Ligase (Parkin) (PARK2) Interaktionspartner

  1. Park2 deficiency exacerbates ethanol-induced dopaminergic neuron damage through p38 (zeige CRK ELISA Kits) kinase dependent inhibition of autophagy and mitochondrial function.

  2. PARK2-dependent acidic postconditioning -induced mitophagy renders the brain resistant to ischemic injury.

  3. Our results indicate that strict maternal transmission of mitochondria relies on mitophagy and uncover a collaboration between MUL1 and PARKIN in this process.

  4. an impaired PINK1-PARK2-mediated neuroimmunology pathway contributes to septic death.

  5. These findings suggest that insufficient mitophagy-mediated PDGFR (zeige PDGFRB ELISA Kits)/PI3K/AKT (zeige AKT1 ELISA Kits) activation, which is mainly attributed to reduced PARK2 expression, is a potent underlying mechanism for myofibroblast differentiation and proliferation in fibroblastic foci formation during idiopathic pulmonary fibrosis pathogenesis

  6. Mfn2 (zeige MFN2 ELISA Kits) downregulation or the exogenous expression of normal Parkin restored cytosolic Ca(2 (zeige CA2 ELISA Kits)+) transients in fibroblasts from patients with PARK2 mutations, a catalytically inactive Parkinson's disease (PD)-related Parkin variant had no effect. Parkin is directly involved in regulating ER-mitochondria contacts and provide new insight into the role of the loss of Parkin function in PD development

  7. Our results provide a molecular explanation for the contribution of Drp1 (zeige CRMP1 ELISA Kits) to the pathogenesis of sporadic Parkinson's disease (PD). These findings indicate that the SNO (zeige SBNO2 ELISA Kits)-Parkin pathway may be a novel therapeutic target to treat PD

  8. These results suggest a previously unidentified role of parkin in mediating endotoxin-induced endothelial proinflammatory signaling and indicate that it may play a critical role in acute inflammation.

  9. These studies suggest that changes in intestinal lipid absorption may play a primary role in protection from nutritional stress in Park2 KO mice by preventing HFD-induced weight gain and highlight the need for tissue-specific models to address the role of PARK2 during metabolic stress.

  10. Parkin negatively regulates the number and connectivity of mitochondria via a Drp1 (zeige CRMP1 ELISA Kits)-independent mechanism.

PARK2 Antigen-Profil

Beschreibung des Gens

The precise function of this gene is unknown\; however, the encoded protein is a component of a multiprotein E3 ubiquitin ligase complex that mediates the targeting of substrate proteins for proteasomal degradation. Mutations in this gene are known to cause Parkinson disease and autosomal recessive juvenile Parkinson disease. Alternative splicing of this gene produces multiple transcript variants encoding distinct isoforms. Additional splice variants of this gene have been described but currently lack transcript support.

Genbezeichner und Symbole assoziert mit PARK2

  • parkin (park) Antikörper
  • parkin RBR E3 ubiquitin protein ligase (PRKN) Antikörper
  • parkin RBR E3 ubiquitin protein ligase (Prkn) Antikörper
  • parkin RBR E3 ubiquitin protein ligase (prkn) Antikörper
  • parkin (CpipJ_CPIJ014867) Antikörper
  • Parkinson disease (autosomal recessive, juvenile) 2, parkin (Park2) Antikörper
  • AR-JP Antikörper
  • CG10523 Antikörper
  • Dmel\\CG10523 Antikörper
  • Dpark Antikörper
  • dpk Antikörper
  • LPRS2 Antikörper
  • Park Antikörper
  • PARK2 Antikörper
  • PDJ Antikörper
  • pdr-1 Antikörper
  • Prkn Antikörper
  • SD01679 Antikörper
  • si:ch211-123f21.1 Antikörper
  • zgc:112390 Antikörper

Bezeichner auf Proteinebene für PARK2

CG10523-PB , CG10523-PC , D-parkin , dparkin , park-PB , park-PC , E3 ubiquitin-protein ligase parkin , Parkinson disease (autosomal recessive, juvenile) 2, parkin , parkinson juvenile disease protein 2 , parkin variant SV5DEL , parkin , parkin protein , parkinson protein 2, E3 ubiquitin protein ligase (parkin)

GENE ID SPEZIES
40336 Drosophila melanogaster
5071 Homo sapiens
56816 Rattus norvegicus
550328 Danio rerio
733673 Sus scrofa
741350 Pan troglodytes
6049109 Culex quinquefasciatus
50873 Mus musculus
612316 Canis lupus familiaris
100724550 Cavia porcellus
530858 Bos taurus
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