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IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. Zusätzlich bieten wir Ihnen Interleukin 31 Antikörper (114) und Interleukin 31 Kits (58) und viele weitere Produktgruppen zu diesem Protein an.
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The first demonstration of the involvement of the IL-31/IL-31R axis in cancer came from studies in patients with mycosis fungoides/Sezary syndrome, the most frequent, cutaneous T cell lymphoma. Tumor cells were shown to produce IL-31, whose serum levels correlated with pruritus intensity.
IL31 and its receptor, IL31RA (zeige IL31RA Proteine), are highly expressed in various human and mouse cancer cell lines, as well as in tumor specimens from cancer patients. MC38 murine colon carcinoma cells depleted of IL31 exhibit an increase in invasive and migratory properties in vitro.
this study shows that IL-31 may be involved in the pathogenesis of asthma and rhinitis; dust mite and mugwort allergy could increase it significantly
While serum TSLP (zeige TSLP Proteine) levels were unaffected by concomitant allergies and atopic comorbidities, serum levels of IL-31, IL-33 (zeige IL33 Proteine) and sST2 (zeige SSTR2 Proteine) were affected to a small extent. We found a positive correlation between TSLP (zeige TSLP Proteine), IL-31 and IL-33 (zeige IL33 Proteine), and an inverse relationship between IL-33 (zeige IL33 Proteine) and sST2 (zeige SSTR2 Proteine)
Suggest that IL-31 gene may play a role in the development of systemic lupus erythematosus.
High IL31 expression is associated with Endometrial Cancer.
In a CML (zeige BCR Proteine) patient with pruritus receiving imatinib mesylate, IL-31 and IL-33 (zeige IL33 Proteine) serum levels were significantly higher than controls. Imatinib could cause keratinocyte injury, the release of IL-33 (zeige IL33 Proteine), and the consequent interaction with its receptor on mast cells, inducing IL-31 secretion. The IL-31/IL-33 (zeige IL33 Proteine) axis may be involved in the pathogenesis of skin side effects related to imatinib mesylate treatment.
Distinct polymorphic variants of the IL-31 gene may be involved in the patho-genesis of mastocytosis, and IL-31 may be involved in the induction of pruritus in patients with mastocytosis.
Serum/pleural fluid IL-31 levels are elevated in tuberculous pleural effusion.
both SCF (zeige KITLG Proteine) and IL-31 play an important role in mediating inflammation and enhancing severity of atopic asthma.
Oncostatin M (zeige OSM Proteine) and interleukin-31: Cytokines, receptors, signal transduction and physiology.
IL-31 upregulates IL-31RA (zeige IL31RA Proteine) expression in DRG neuron cell bodies, and cutaneous-injected IL-31-induced itching is enhanced by DRG IL-31RA (zeige IL31RA Proteine) expression in mice
our results suggest a functional cooperation between NFAT1 (zeige NFAT1 Proteine) and JunB (zeige JUNB Proteine) in mediating IL-31 gene expression in CD4 (zeige CD4 Proteine)(+) T cells
Data not only illustrate various functions that cysteines perform during IL-31 biosynthesis and secretion, but also highlight their potential roles in cytokine effector functions.
IL-31 may be involved in promoting the dermatitis and epithelial responses that characterize allergic and non-allergic diseases
IL-31 interaction with IL-31 receptor (IL-31R) is identified in an acute model of T helper cell type 2 inflammation in the lung.
these data provide the first evidence of a function for IL-31-IL-31R interactions in limiting the magnitude of type 2 inflammatory responses within the intestine.
IL31, which is made principally by activated Th2-type T cells, interacts with a heterodimeric receptor consisting of IL31RA (MIM 609510) and OSMR (MIM 601743) that is constitutively expressed on epithelial cells and keratinocytes. IL31 may be involved in the promotion of allergic skin disorders and in regulating other allergic diseases, such as asthma (Dillon et al., 2004
, interleukin 31