TNFSF11 (Denosumab Biosimilar) Antikörper
(TNFSF11 (Denosumab Biosimilar))
This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. Two alternatively spliced transcript variants have been found. [provided by RefSeq, Jul 2008].
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Empfohlene TNFSF11 (Denosumab Biosimilar) Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
FACS, in vivo
Validierungen
Kat. Nr.
ABIN7200656
Menge
1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
FACS
Validierungen
Kat. Nr.
ABIN7093075
Menge
100 μg
Datenblatt
Datenblatt
Synonyme und alternative Namen zu TNFSF11 (Denosumab Biosimilar)
TNF superfamily member 11 (TNFSF11), CD254, hRANKL2, ODF, OPGL, OPTB2, RANKL, sOdf, TRANCEBezeichner auf Proteinebene für TNFSF11 (Denosumab Biosimilar)
- TNF-related activation-induced cytokine
- osteoclast differentiation factor
- osteoprotegerin ligand
- receptor activator of nuclear factor kappa B ligand
- receptor activator of nuclear factor kappa-B ligand
- tumor necrosis factor ligand superfamily member 11
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