IL-1 beta Protein

Produktnummer ABIN7849736

Dieses Recombinant IL-1 beta-Protein wird in Escherichia coli (E. coli) exprimiert.

Kurzübersicht für IL-1 beta Protein (ABIN7849736)

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Protein-Typ: Recombinant

Spezies: Human

Quelle: Escherichia coli (E. coli)

Applikation: SDS-PAGE (SDS), ELISA

Reinheit: >90 % by SDS-PAGE

Produktdetails

Verwendungszweck: Recombinant Human Interleukin-1beta, IL1B Protein

Endotoxin-Niveau: < 0.1 ng/μg (1 EU/μg) by LAL test

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized,Each vial contains 10 mM Phosphate bufferand 200 mM NaCl( pH 7.0) without preservatives.

Konservierungsmittel: Without preservative

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Ship at 4°C. Upon receipt,store at -20°C for long term. Avoid repeated freeze and thaw cycles.

Antigendetails

Target: IL-1 beta (IL1B) (Interleukin 1, beta (IL1B))

Andere Bezeichnung: IL1B

Hintergrund:

Synonyms: Interleukin-1 beta, IL1B, IL-1 beta, Catabolin, IL1F2, IL-1B, IL-1, IL1-BETA, IL1F2, interleukin 1 beta.

Description: Recombinant human IL-1 beta protein.

Background: Interleukin-1β (IL-1β) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. It can reset glucose homeostasis at central levels. It cause oligodendrocyte death in coculture with astrocytes and microglia, and also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes. Pathak et al. (2011) proposed that IL1B blockade may be a viable therapy for patients with autoimmune inner ear disease or sensorineural hearing loss that fail to respond to corticosteroids.

Pathways: NF-kappaB Signalweg, Interferon-gamma Pathway, TLR Signalweg, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagie, Cancer Immune Checkpoints, Inflammasome