CD40 Protein (CD40) (AA 21-193) (hIgG-His-tag)

Produktnummer ABIN7596337

Dieses Recombinant CD40-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für CD40 Protein (CD40) (AA 21-193) (hIgG-His-tag) (ABIN7596337)

Target: CD40

Protein-Typ: Recombinant

Spezies: Human

Quelle: HEK-293 Cells

Applikation: SDS-PAGE (SDS)

Reinheit: > 95% by SDS - PAGE

Produktdetails

Proteineigenschaft: AA 21-193

Aufreinigungstag / Konjugat: Dieses CD40 Protein ist gelabelt mit hIgG-His-tag.

Sequenz: EPPTACREKQ YLINSQCCSL CQPGQKLVSD CTEFTETECL PCGESEFLDT WNRETHCHQH KYCDPNLGLR VQQKGTSETD TICTCEEGWH CTSEACESCV LHRSCSPGFG VKQIATGVSD TICEPCPVGF FSNVSSAFEK CHPWTSCETK DLVVQQAGTN KTDVVCGPQD RLR

Endotoxin-Niveau: < 1 EU per 1ug of protein (determined by LAL method)

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Can be stored at +2°C to +8°C for 1 week. For long term storage, aliquot and store at -20°C to -80°C. Avoid repeated freezing and thawing cycles.

Antigendetails

Target: CD40

Andere Bezeichnung: CD40/TNFRSF5

Hintergrund: CD40, also known as TNFRSF5, is a member of the TNF receptor superfamily. It transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglubiln secretion. CD40 is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. CD40 Molecule is a potential target for cancer immunotherapy. There are number of completed and ongoing clinical trials where agonistic anti-CD40 monoclonal antibodies are employed to activate an anti-tumor T cell response via activation of dendritic cells. Recombinant human CD40, fused to hIgG-His-tag at C-terminus, was expressed in HEK293 cell and purified by using conventional chromatography techniques.

Molekulargewicht: 46.1kDa (412aa)

NCBI Accession: NP_001241

Pathways: NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints