CD40 Protein (CD40) (AA 20-193) (His tag)

Produktnummer ABIN7320760

Dieses Recombinant CD40-Protein wird in HEK-293 Cells produziert.

Kurzübersicht für CD40 Protein (CD40) (AA 20-193) (His tag) (ABIN7320760)

Target: CD40

Protein-Typ: Recombinant

Spezies: Maus

Quelle: HEK-293 Cells

Reinheit: > 95 % as determined by reducing SDS-PAGE.

Produktdetails

Proteineigenschaft: AA 20-193

Aufreinigungstag / Konjugat: Dieses CD40 Protein ist gelabelt mit His tag.

Verwendungszweck: Recombinant Mouse CD40/TNFRSF5 Protein (His Tag)

Sequenz: Leu20-Arg193

Produktmerkmale: Recombinant Mouse CD40 is produced by our Mammalian expression system and the target gene encoding Leu20-Arg193 is expressed with a 6His tag at the C-terminus.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: < 1.0 EU per μg of the protein as determined by the LAL method.

Biological Activity Comment: Not validated for activity

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Normally 5 % - 8 % trehalose, mannitol and 0.01 % Tween 80 are added as protectants before lyophilization.

Lagerung: 4 °C,-20 °C,-80 °C

Informationen zur Lagerung: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Haltbarkeit: 12 months

Antigendetails

Target: CD40

Andere Bezeichnung: CD40/TNFRSF5

Hintergrund: B-cell surface antigen CD40,Bp50,CD40,CD40L receptor,HIGM1,I326936,IGM,IMD3,T-BAM,TNFRSF5,TRAP,Tnfrsf5,Tumor necrosis factor receptor superfamily member 5,p50,CD40 is a Type I Transmembrane Glycoprotein that belongs to the TNF Receptor Superfamily. CD40 is expressed in B cells, follicular dendritic cells, dendritic cells, activated monocytes, macrophages, endothelial cells, vascular smooth muscle cells, and several tumor cell lines. The extracellular domain of CD40 is characterized by Cysteine rich repeat regions. Interaction of CD40 with its ligand (CD40L) leads to aggregation of CD40 Molecules, which in turn interact with cytoplasmic components to initiate signaling pathways. Several different TRAF proteins (adaptor proteins) have been identified to serves as mediators of the signal transduction. CD40 plays an essential role in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation.

Molekulargewicht:

Calculated MW: 20.2 kDa

Observed MW: 22-28 kDa

Gen-ID: 21939

UniProt: P27512

Pathways: NF-kappaB Signalweg, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints