IL-6 Protein
Kurzübersicht für IL-6 Protein (ABIN7539339)
Target
Alle IL-6 (IL6) Proteine anzeigenProtein-Typ
Biologische Aktivität
Spezies
Quelle
Reinheit
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Verwendungszweck
- IL-6
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Sequenz
- MFPTSQVRRG DFTEDTTPNR PVYTTSQVGG LITHVLWEIV EMRKELCNGN SDCMNNDDAL AENNLKLPEI QRNDGCYQTG YNQEICLLKI SSGLLEYHSY LEYMKNNLKD NKKDKARVLQ RDTETLIHIF NQEVKDLHKI VLPTPISNAL LTDKLESQKE WLRTKTIQFI LKSLEEFLKV TLRSTRQT
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Spezifität
- Chromosomal location:5 B1, 5 17.0 cM
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Kreuzreaktivität
- Affe, Maus, Ratte, Forelle
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Produktmerkmale
- Length (aa):188
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Endotoxin-Niveau
- < 0.1 ng/μg of protein (<1EU/μg)
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Interleukin 6 (IL6) (AA 30-212) protein (mFc-His Tag)
IL6 Spezies: Human Wirt: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % as determined by Bis-Tris PAGE,> 90 % as determined by HPLC Active
Interleukin 6 (IL6) (AA 28-212) (Active) protein (His tag)IL6 Spezies: Cynomolgus Wirt: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Interleukin 6 (IL6) (AA 29-212) (Active) proteinIL6 Spezies: Human Wirt: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)IL6 Spezies: Maus Wirt: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Spezies: Human Wirt: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Spezies: Human Wirt: HEK-293 Cells > 97 % AcA, CC Active
Interleukin 6 (IL6) (AA 47-241) protein (His tag)IL6 Spezies: Huhn Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 6 (IL6) (AA 21-207) protein (His tag)IL6 Spezies: Hund Wirt: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Applikationshinweise
- The ED50 as determined by the dose-dependent stimulation of murine hybridoma B9 cells is in the range of 5-20 pg/mL.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Lyophilized
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Rekonstitution
- 50 mM Acetic Acid
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Buffer
- 50 mM Acetic Acid
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- IL-6 (IL6) (Interleukin 6 (IL6))
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Andere Bezeichnung
- IL-6
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Hintergrund
- Il6, Il-6,IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant murine IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
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Molekulargewicht
- 21.7 kDa
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Gen-ID
- 16193
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NCBI Accession
- NM_031168, NP_112445
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UniProt
- P08505
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Pathways
- TLR Signalweg, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagie, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
Target
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